Protein Alignment Hmt-1 and hmt-1

DIOPT Version :9

• Sequence 1: NP_650503.1
• Gene: Hmt-1 / 41925
• FlyBaseID: FBgn0038376
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001022812.1
• Gene: hmt-1 / 176540
• WormBaseID: WBGene00001815
• Length: 801
• Species: Caenorhabditis elegans
• Alignment Length: 838
• Identity: 382/838 - (45%)
• Similarity: 522/838 - (62%)
• Gaps: 84/838 - (10%)

  Fly    27 VGPA--------VYGGFLLLFGSIQLLM---------YRKYATRITDPTQISKSRL-FAMQLFLL 73
            :||:        || .|.::...|.|.:         ||    |:||....|.|:| .:..|.:.
 Worm    18 IGPSCNKIISFGVY-TFFIVVNFIVLCIPNSNSANNNYR----RMTDDDASSTSKLTISKILSIC 77

  Fly    74 LLLPVL--ALLRFLMNARIYPDSAVYGYMIFSTCV-VCFSYPFSICLILKERYYQLPSMPTRGHG 135
            .:..|:  ::..|......:|    |.:::.:.|| ..|.:..|:|...|.|  ..||.|.
 Worm    78 TIFAVICQSIFYFCFTFYFHP----YTHLLLAFCVSKLFFWILSLCSFSKWR--NQPSTPI---- 132

  Fly   136 LVLLLFWTLAFINESLAFIN-LRHEDWWFHLK-TNKDQIEMGLFVTRFLCSLLIF----VLGLKA 194
                   :|||...:...|: :...||..:.: |:|::.::..::.......::|    |.||
 Worm   133 -------SLAFAFSAALLIHCIPLTDWKKYFEPTSKNRGDLTFYIIELALVTVVFFFTIVTGL-- 188

  Fly   195 PGIMAPYNPHQRLDNDTANESQGNVQTGSAFRNGWRKLRTVFPYLWPKKNIALQIAVIVCIILLL 259
                  :|            ..|.....||:.|..:|:.||.||:||.|:|:||:.|:.|:.||:
 Worm   189 ------FN------------FSGCSSRESAWNNLSKKVVTVAPYIWPTKSISLQLRVVFCLFLLI 235

  Fly   260 AGRVIKLFLPIYRKKLVDSLTIAPIVFRWDFVLIYVALSFLQGGGTGSMGLF-NNLRTFLWIRVQ 323
            .||:|.:.|||..|.:||.|. .|..|::..:.:...|.|||  |.|:||.| |.:||:|||.:|
 Worm   236 IGRLINVSLPILSKWIVDELA-TPDTFQYSLLFLATFLKFLQ--GNGAMGGFLNTVRTYLWIPIQ 297

  Fly   324 QYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVA 388
            ||||||:|:|||:|||.|||||||.||||:|||||||||.|:||:||||:|::.|||.|:::||.
 Worm   298 QYTTRELEVELFKHLHSLSLRWHLSRKTGQVLRVMDRGTSSVNNILNYILFNVVPTIADIVIAVI 362

  Fly   389 YFVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKYQRRMNLADNEQRARSVDSLLNFETVKYYGA 453
            :|..|||.:||||||.||.||:..||:||||||:|.|..|..||...|.:.|||:|:|||||||.
 Worm   363 FFFSAFNAYFGLIVFGTMALYLTVTISITEWRTQYIREANEKDNATSAIATDSLINYETVKYYGN 427

  Fly   454 EHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVHHQTLTVGDFVL 518
            |.:||:.::.||..||..|:.:..:|..||..||.|:.:|::.||:..||::||.:||||||:||
 Worm   428 EEFEVNRFKNAIESYQVTEWKTQASLAFLNCLQNAIIGIGMIGGSVFVVYMIVHEKTLTVGDYVL 492

  Fly   519 FSTYLMELYMPLNWFGTYYRAIQKNFVDMENMFDLLKEEEEIVDAPGCSPLLTAGGGIEFSNVTF 583
            |:|||::||.|||:|||.||.|||.||||||||||:.:|.|:.|.|...|.....|.|...|:||
 Worm   493 FTTYLLQLYTPLNFFGTIYRVIQKAFVDMENMFDLMNDEVEVKDLPHALPYTDPRGTISVKNLTF 557

  Fly   584 GYSPEKIVLRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLFRFYDVQTGAILIDGQNIKLVQQQSL 648
            .|:....|::|:||.:..|:|||:||.||:||||::|||||.::...|:|..||.:::.....||
 Worm   558 EYNTGLPVIKNISFEIGNGQTVALVGSSGSGKSTLIRLLFRLFESTEGSIEFDGIDVRNYTMHSL 622

  Fly   649 RKAIGVVPQDTVLFNNTIFYNIEYAKLGASDEAVYEAARAADIHERILGFPEKYETKVGERGLRL 713
            |:.||:|||||||||:||.|||.:.:..||||.|.|||:||.|||:|...||.|.|.||||||:|
 Worm   623 RQQIGIVPQDTVLFNDTIMYNIRFGRPDASDEEVIEAAKAAMIHEKITSLPEGYATMVGERGLKL 687

  Fly   714 SGGEKQRVAIARTLLKAPIIVLLDEATSALDTHTERNIQAALARVCANRTTIIVAHRLSTIIHAD 778
            |||||||||||||:||.|..:.||||||||||.|||.||..|.::|.:||.::|||||||:::||
 Worm   688 SGGEKQRVAIARTILKKPQFIFLDEATSALDTPTERAIQKCLEKLCKSRTGVVVAHRLSTVVNAD 752

  Fly   779 EILVLQQGSIAERGRHEELVLREDGIYADMWQQQLKNLDAEQSGGSDNGDASAESGSE 836
            .||||.:|.|.|||.|:|| |.:.|.||.||:.|:    |||..      .|.|.|.|
 Worm   753 LILVLDKGIILERGNHKEL-LAQQGTYASMWEAQI----AEQRA------KSIELGEE 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:292803	52/240 (22%)
		ABC_membrane	255..530	CDD:279056	151/275 (55%)
		ATM1	314..811	CDD:227590	290/496 (58%)
		ABCC_ATM1_transporter	576..812	CDD:213220	136/235 (58%)
hmt-1	NP_001022812.1	ABC_membrane	231..504	CDD:294371	151/275 (55%)
		ATM1	289..782	CDD:227590	288/493 (58%)
		ABCC_ATM1_transporter	550..785	CDD:213220	136/235 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166771
Domainoid	1	1.000	313	1.000	Domainoid score	I705
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11375
Inparanoid	1	1.050	657	1.000	Inparanoid score	I408
Isobase	1	0.950	-	0	Normalized mean entropy	S1124
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	1	1.000	-	-		FOG0004593
OrthoInspector	1	1.000	-	-		oto19451
orthoMCL	1	0.900	-	-		OOG6_100761
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3271
SonicParanoid	1	1.000	-	-		X3206
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750