Protein Alignment Hmt-1 and ABCB7

DIOPT Version :10

• Sequence 1: NP_650503.1
• Gene: Hmt-1 / 41925
• FlyBaseID: FBgn0038376
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: XP_001688853.1
• Gene: ABCB7 / 1276974
• VectorBaseID: AGAMI1_001922
• Length: 819
• Species: Anopheles gambiae
• Alignment Length: 666
• Identity: 259/666 - (38%)
• Similarity: 393/666 - (59%)
• Gaps: 45/666 - (6%)

  Fly   195 PGIMAPYNP------------HQRLDNDTANESQGNVQTGSAFRNGWRKLRTVFPYLWPKKNIAL 247
            |.:.||:..            |.....::.....|...|.:..      ::.:..|:|||.:..:
Mosquito   176 PSLQAPFTKQPPPIRHCFHLGHHPASGESIGTYDGPEITATDM------IKAMATYIWPKDDAMV 234

  Fly   248 QIAVIVCIILLLAGRVIKLFLPIYRKKLVDSLTIAPIVFRWDFV---LIYVALSFLQGGGTGSMG 309
            :..|::.:.||...:|:.:.:|...|..||:|.    |...|.|   ...:.:|.|.|.|....|
Mosquito   235 RKRVLISLGLLGGAKVLNVCVPFLFKMGVDNLN----VLSMDTVPQAASALTISVLLGYGIARAG 295

  Fly   310 L--FNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYI 372
            .  ||.||..::.||.|::.|:|...:|.|||.|.|::||.::||.:.:.:|||:..||.:|..:
Mosquito   296 AAGFNELRNAVFARVAQHSIRKIATNVFLHLHNLDLQFHLSKQTGALSKTIDRGSRGINFVLTAM 360

  Fly   373 VFSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKYQRRMNLADNEQRAR 437
            ||::.||:.:|.:..:.........:..:....:.:|.|.|:|:|:||||::..||.|:||...:
Mosquito   361 VFNVVPTMFELALVSSILGMKCGMAYAALSMGCVGVYSAYTLAVTQWRTKFRIYMNQAENEAGNK 425

  Fly   438 SVDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCV 502
            :||||:|:|||||:..|.||.:.|.:.:.||:.....:..:|.:||..||.|..:.|....::..
Mosquito   426 AVDSLINYETVKYFNNEQYEANRYDQVLKKYEDASLKTSTSLALLNFGQNAIFSVALSTIMVMAA 490

  Fly   503 YLVVHHQTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKNFVDMENMFDLLKEEEEIVDAPGCS 567
            ..:...: :||||.|:.:..|.:|.:||.:.|:.||.:::..:||..||.|:..:..|.......
Mosquito   491 NEIAQGR-MTVGDLVMVNGLLFQLSIPLGFLGSVYREVRQALLDMRTMFTLMGVQSAIQSRANAP 554

  Fly   568 PL----LTAGGGIEFSNVTFGYSPEKIVLRNVSFTVPAGKTVAIVGPSGAGKSTIMRLLFRFYDV 628
            ||    .||  .|||.||.|.|:....:.:::|||:||||.:||||.||:|||:::||||||::.
Mosquito   555 PLDVRRETA--SIEFRNVGFRYAQSNEIFKDLSFTIPAGKKIAIVGGSGSGKSSMVRLLFRFFEP 617

  Fly   629 QTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEYAKLGASDEAVYEAARAADIHE 693
            .||.|||:||||:.|..|||||||.|||||:|||::||.:||.|..|..|...:..|||.||:|:
Mosquito   618 STGQILINGQNIREVDLQSLRKAIAVVPQDSVLFHDTIRHNIHYGDLSKSQTELENAARMADLHD 682

  Fly   694 RILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLDEATSALDTHTERNIQAALARV 758
            .||.:|::|||:||||||:|||||||||||||.:||...|::.|||||:||:.||:||..||||.
Mosquito   683 SILQWPKQYETQVGERGLKLSGGEKQRVAIARAILKNSPILIFDEATSSLDSITEQNILQALARA 747

  Fly   759 CANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGIYADMW--QQQLKNLDAEQS 821
            ..|||:|.:||||||::.|||||||:.|.:.:||.|::| ||..|:|..:|  |.:|.|:.:::
Mosquito   748 TDNRTSICIAHRLSTVMDADEILVLENGRVGQRGTHDQL-LRSGGLYTKLWDTQNRLYNIGSKK- 810

  Fly   822 GGSDNGDASAESGSEK 837
                   .:...|.||
Mosquito   811 -------PTKPEGEEK 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:465049	7/57 (12%)
		ATM1	222..821	CDD:444078	250/609 (41%)
ABCB7	XP_001688853.1	ATM1	227..802	CDD:444078	247/582 (42%)