DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4546 and CKMT1A

DIOPT Version :9

Sequence 1:	NP_650501.1	Gene:	CG4546 / 41922	FlyBaseID:	FBgn0038373	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001308856.1	Gene:	CKMT1A / 548596	HGNCID:	31736	Length:	448	Species:	Homo sapiens

Alignment Length:	360	Identity:	134/360 - (37%)
Similarity:	193/360 - (53%)	Gaps:	30/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 SSLLRKYLTPELLEEYMLVTTPAPVDAYLYD-CAVSGFEHHDAP----VGIFAADADSYDVFNKL 172
            ::.:..:|||.:.......|||.   .:..| |..:|.::...|    ||:.|.|.::|:||..|
Human    91 NNCMASHLTPAVYARLCDKTTPT---GWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADL 152

  Fly   173 FDPIIKDYHGQMDNENDVLQKDPD-----FGNVDEIENLDPERKYILSARIRLARNIEGLPFFPK 232
            |||:|::.|...|........|.|     .|..||        :|:||:|:|..|:|.||...|.
Human   153 FDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDE--------RYVLSSRVRTGRSIRGLSLPPA 209

  Fly   233 LTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMVKRHILFQRG-DEKLTTAGCYRF 296
            .|..:..|||..|..|...:.|:|.|.|..::::....|.:::..|.||.:. ...||.||..|.
Human   210 CTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARD 274

  Fly   297 WPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRLVNGLTELEKTL-----AFARHP 356
            ||..||::||..::||||||.:||..::||.:.|::..|:.|...||.|:|:.:     .|..:.
Human   275 WPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNE 339

  Fly   357 RYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQLQVRGTDGGELSTVEDGVMDISN 421
            |.|.:..||:||||.|||.|||:||||||| .|...:.|..:||.||| ||..:....||.||||
Human   340 RLGYILTCPSNLGTGLRAGVHIKLPLLSKD-SRFPKILENLRLQKRGT-GGVDTAATGGVFDISN 402

  Fly   422 KRKLGFTEFELVKTLQDGVVTLINAEEELEISGQE 456
            ..:||.:|.|||:.:.|||..||:.|..|| .||:
Human   403 LDRLGKSEVELVQLVIDGVNYLIDCERRLE-RGQD 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4546	NP_650501.1	arginine_kinase_like	89..450	CDD:153079	130/352 (37%)
CKMT1A	NP_001308856.1	creatine_kinase_like	80..437	CDD:153076	134/360 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3115
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2904
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm8556
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.840