DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4546 and Ckm

DIOPT Version :9

Sequence 1:	NP_650501.1	Gene:	CG4546 / 41922	FlyBaseID:	FBgn0038373	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_036662.1	Gene:	Ckm / 24265	RGDID:	2358	Length:	381	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	129/377 - (34%)
Similarity:	198/377 - (52%)	Gaps:	30/377 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KSPEEYQELTTEGYKSLMDDEENVSSLLRKYLTPELLEEYMLVTTPAPVDAYLYDCAVSGFEHHD 153
            ||.|||.:|:..            ::.:.|.|||:|..:.....||:...  |.|...:|.::..
  Rat    15 KSQEEYPDLSKH------------NNHMAKVLTPDLYNKLRDKETPSGFT--LDDVIQTGVDNPG 65

  Fly   154 AP----VGIFAADADSYDVFNKLFDPIIKDYHGQMDNENDVLQKDPDFGNVDEIENLDPERKYIL 214
            .|    ||..|.|.:||.||..||||||:|.||.. ...|..:.|.:..|:...::|||  .|:|
  Rat    66 HPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGF-KPTDKHKTDLNHENLKGGDDLDP--NYVL 127

  Fly   215 SARIRLARNIEGLPFFPKLTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMVKRHI 279
            |:|:|..|:|:|....|..:..:...||:....|..::.||..|.|..:..:..:.|.:::..|.
  Rat   128 SSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHF 192

  Fly   280 LFQRGDEKLTTA-GCYRFWPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRLVNGL 343
            ||.:....|..| |..|.||..||::||..::||:|||.:||:.::||.:.|::.:|:.|...||
  Rat   193 LFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGL 257

  Fly   344 TELEKTLAFARHP-----RYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQLQVRG 403
            .::|:....|.||     ..|.:..||:||||.||..||::|..|||.| :...:....:||.||
  Rat   258 QKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLANLSKHP-KFEEILTRLRLQKRG 321

  Fly   404 TDGGELSTVEDGVMDISNKRKLGFTEFELVKTLQDGVVTLINAEEELEISGQ 455
            |.|.:.:.| ..|.||||..:||.:|.|.|:.:.|||..::..|::|| .||
  Rat   322 TGGVDTAAV-GAVFDISNADRLGSSEVEQVQLVVDGVKLMVEMEKKLE-KGQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4546	NP_650501.1	arginine_kinase_like	89..450	CDD:153079	125/370 (34%)
Ckm	NP_036662.1	creatine_kinase_like	16..373	CDD:153076	128/376 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341347
Domainoid	1	1.000	197	1.000	Domainoid score	I3004
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2802
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm9032
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.770