DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4546 and Ckb

DIOPT Version :9

Sequence 1:	NP_650501.1	Gene:	CG4546 / 41922	FlyBaseID:	FBgn0038373	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_036661.3	Gene:	Ckb / 24264	RGDID:	2357	Length:	381	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	136/377 - (36%)
Similarity:	208/377 - (55%)	Gaps:	36/377 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 EEYQELTTEGYKSLMDDEENVSSLLRKYLTPELLEEYMLVTTPAPVDAYLYDCAV-SGFEHHDAP 155
            :|:.:|::.            ::.:.|.|||||..|.....||:   .:..|.|: :|.::...|
  Rat    18 DEFPDLSSH------------NNHMAKVLTPELYAELRAKCTPS---GFTLDDAIQTGVDNPGHP 67

  Fly   156 ----VGIFAADADSYDVFNKLFDPIIKDYHG--QMDNENDVLQKDPDFGNVDEIENLDPERKYIL 214
                ||..|.|.:|||||..||||||:|.||  |..:|:.. ..:||  |:...::|||  .|:|
  Rat    68 YIMTVGAVAGDEESYDVFKDLFDPIIEDRHGGYQPSDEHKT-DLNPD--NLQGGDDLDP--NYVL 127

  Fly   215 SARIRLARNIEGLPFFPKLTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMVKRHI 279
            |:|:|..|:|.|....|..:..:...:|:....|..::||:|.|.|..:..:....|.:::..|.
  Rat   128 SSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHF 192

  Fly   280 LFQRGDEKLTTA-GCYRFWPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRLVNGL 343
            ||.:....|..| |..|.||..||::||..:|||:|:|.:||:.::||.:.|::.:|:.|...||
  Rat   193 LFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGL 257

  Fly   344 TELE-----KTLAFARHPRYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQLQVRG 403
            |::|     |...|..:|..|.:..||:||||.|||.|||:||.|.|. ::...:.:..:||.||
  Rat   258 TQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKH-EKFSEVLKRLRLQKRG 321

  Fly   404 TDGGELSTVEDGVMDISNKRKLGFTEFELVKTLQDGVVTLINAEEELEISGQ 455
            |.|.:.:.| .||.|:||..:|||:|.|||:.:.|||..||..|:.|| .||
  Rat   322 TGGVDTAAV-GGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLE-QGQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4546	NP_650501.1	arginine_kinase_like	89..450	CDD:153079	132/370 (36%)
Ckb	NP_036661.3	creatine_kinase_like	16..373	CDD:153076	136/377 (36%)
Ckb	NP_036661.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..122		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341346
Domainoid	1	1.000	197	1.000	Domainoid score	I3004
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2802
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm9032
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.770