DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4546 and ckbb

DIOPT Version :9

Sequence 1:	NP_650501.1	Gene:	CG4546 / 41922	FlyBaseID:	FBgn0038373	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_775329.1	Gene:	ckbb / 140744	ZFINID:	ZDB-GENE-020103-2	Length:	381	Species:	Danio rerio

Alignment Length:	375	Identity:	133/375 - (35%)
Similarity:	202/375 - (53%)	Gaps:	32/375 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 EEYQELTTEGYKSLMDDEENVSSLLRKYLTPELLEEYMLVTTPAPVDAYLYDCAVSGFEHHDAP- 155
            :||.:||..            ::.:.|.||||:........||:...  |.|...:|.::...|
Zfish    18 QEYPDLTKH------------NNHMAKVLTPEMYANLRDKQTPSGFT--LDDVIQTGVDNPGHPF 68

  Fly   156 ---VGIFAADADSYDVFNKLFDPIIKDYH-GQMDNENDVLQKDPDFGNVDEIENLDPERKYILSA 216
               ||..|.|.::||||.:|.||:|:|.| |....:......:||  |:...::|||  .|:||:
Zfish    69 IMTVGCVAGDEETYDVFKELLDPVIEDRHGGYKPTDKHKTDLNPD--NLKGGDDLDP--NYVLSS 129

  Fly   217 RIRLARNIEGLPFFPKLTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMVKRHILF 281
            |:|..|:|.|....|..:..:...:|.....|...:||:|.|.|..:.|:..|.|.:::..|.||
Zfish   130 RVRTGRSIRGFCLPPHCSRGERRGIESLSVEALGALDGDLKGKYYALKDMTEEEQQQLIDDHFLF 194

  Fly   282 QRGDEKLTTA-GCYRFWPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRLVNGLTE 345
            .:....|..| |..|.||..||::||..:|||:|||.:||:.::||.:.|::.:|:||...|||:
Zfish   195 DKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMREVFNRFCTGLTK 259

  Fly   346 L-----EKTLAFARHPRYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQLQVRGTD 405
            :     ||...|..:...|.:..||:||||.||..||::||.:||. ::...:.:..:||.|||.
Zfish   260 IEELFKEKGHEFMWNEHLGYVLTCPSNLGTGLRGGVHVKLPNVSKH-EKFGEILKRLRLQKRGTG 323

  Fly   406 GGELSTVEDGVMDISNKRKLGFTEFELVKTLQDGVVTLINAEEELEISGQ 455
            |.:.:.| .||.||||..:|||:|.|||:.:.|||..|:..|:.|| |||
Zfish   324 GVDTAAV-GGVFDISNADRLGFSEVELVQMVVDGVKLLVEMEKRLE-SGQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4546	NP_650501.1	arginine_kinase_like	89..450	CDD:153079	128/368 (35%)
ckbb	NP_775329.1	creatine_kinase_like	16..373	CDD:153076	133/375 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581291
Domainoid	1	1.000	198	1.000	Domainoid score	I3023
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2808
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm6403
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.770