DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4546 and CKM

DIOPT Version :9

Sequence 1:	NP_650501.1	Gene:	CG4546 / 41922	FlyBaseID:	FBgn0038373	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001815.2	Gene:	CKM / 1158	HGNCID:	1994	Length:	381	Species:	Homo sapiens

Alignment Length:	379	Identity:	128/379 - (33%)
Similarity:	199/379 - (52%)	Gaps:	34/379 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KSPEEYQELTTEGYKSLMDDEENVSSLLRKYLTPELLEEYMLVTTPA--PVDAYLYDCAVSGFEH 151
            |..|||.:|:..            ::.:.|.||.||.::.....||:  .||    |...:|.::
Human    15 KPEEEYPDLSKH------------NNHMAKVLTLELYKKLRDKETPSGFTVD----DVIQTGVDN 63

  Fly   152 HDAP----VGIFAADADSYDVFNKLFDPIIKDYHGQMDNENDVLQKDPDFGNVDEIENLDPERKY 212
            ...|    ||..|.|.:||:||.:||||||.|.||.. ...|..:.|.:..|:...::|||  .|
Human    64 PGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGY-KPTDKHKTDLNHENLKGGDDLDP--NY 125

  Fly   213 ILSARIRLARNIEGLPFFPKLTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMVKR 277
            :||:|:|..|:|:|....|..:..:...||:....|..::.||..|.|..:..:..:.|.:::..
Human   126 VLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDD 190

  Fly   278 HILFQRGDEKLTTA-GCYRFWPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRLVN 341
            |.||.:....|..| |..|.||..||::||..::||:|||.:||:.::||.:.|::.:|:.|...
Human   191 HFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCV 255

  Fly   342 GLTELEKTLAFARHP-----RYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQLQV 401
            ||.::|:....|.||     ..|.:..||:||||.||..||::|..|||.| :...:....:||.
Human   256 GLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHP-KFEEILTRLRLQK 319

  Fly   402 RGTDGGELSTVEDGVMDISNKRKLGFTEFELVKTLQDGVVTLINAEEELEISGQ 455
            |||.|.:.:.| ..|.|:||..:||.:|.|.|:.:.|||..::..|::|| .||
Human   320 RGTGGVDTAAV-GSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLE-KGQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4546	NP_650501.1	arginine_kinase_like	89..450	CDD:153079	124/372 (33%)
CKM	NP_001815.2	creatine_kinase_like	16..373	CDD:153076	127/378 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147545
Domainoid	1	1.000	196	1.000	Domainoid score	I3115
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2904
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm8556
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.770