DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4546 and CKB

DIOPT Version :9

Sequence 1:	NP_650501.1	Gene:	CG4546 / 41922	FlyBaseID:	FBgn0038373	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001349460.1	Gene:	CKB / 1152	HGNCID:	1991	Length:	405	Species:	Homo sapiens

Alignment Length:	381	Identity:	132/381 - (34%)
Similarity:	197/381 - (51%)	Gaps:	56/381 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LRKYLTPELLEEYMLVTTPAPVDAYLYDCAVSGFEHHDAP----VGIFAADADSYDVFNKLFDPI 176
            :.|.|||||..|....:||:...  |.|...:|.::...|    ||..|.|.:||:||..|||||
Human    30 MAKVLTPELYAELRAKSTPSGFT--LDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPI 92

  Fly   177 IKDYHG----QMDNENDVLQKDPDFGNVDEI---------------------------ENLDPER 210
            |:|.||    ..:::.|:        |.|.:                           ::|||
Human    93 IEDRHGGYKPSDEHKTDL--------NPDNLQVRGCGRAGRAGPGSSGAHSRLASQGGDDLDP-- 147

  Fly   211 KYILSARIRLARNIEGLPFFPKLTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMV 275
            .|:||:|:|..|:|.|....|..:..:...:|:....|..::||:|.|.|..:..:....|.:::
Human   148 NYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLI 212

  Fly   276 KRHILFQRGDEKLTTA-GCYRFWPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRL 339
            ..|.||.:....|..| |..|.||..||::||..:|||:|||.:||:.::||.:.|::.:|:.|.
Human   213 DDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRF 277

  Fly   340 VNGLTELE-----KTLAFARHPRYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQL 399
            ..|||::|     |...|..:|..|.:..||:||||.|||.|||:||.|.|. ::...:.:..:|
Human   278 CTGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGKH-EKFSEVLKRLRL 341

  Fly   400 QVRGTDGGELSTVEDGVMDISNKRKLGFTEFELVKTLQDGVVTLINAEEELEISGQ 455
            |.|||.|.:.:.| .||.|:||..:|||:|.|||:.:.|||..||..|:.|| .||
Human   342 QKRGTGGVDTAAV-GGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLE-QGQ 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4546	NP_650501.1	arginine_kinase_like	89..450	CDD:153079	128/374 (34%)
CKB	NP_001349460.1	creatine_kinase_like	16..397	CDD:153076	132/381 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147544
Domainoid	1	1.000	196	1.000	Domainoid score	I3115
eggNOG	1	0.900	-	-		E1_COG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2904
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58958
OrthoDB	1	1.010	-	-		D287050at33208
OrthoFinder	1	1.000	-	-		FOG0000437
OrthoInspector	1	1.000	-	-		mtm8556
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X315
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.770