DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-d and vtg4

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_001038759.2	Gene:	vtg4 / 678536	ZFINID:	ZDB-GENE-001201-3	Length:	1358	Species:	Danio rerio

Alignment Length:	907	Identity:	175/907 - (19%)
Similarity:	321/907 - (35%)	Gaps:	209/907 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NKQMLYEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNNSGEKF 92
            :|...|:||. :|:|..||:...:|    |..|..|:.|...:|......| :|.:....:|
Zfish    27 DKTYKYKYEA-LLLGGLPQEGLARA----GIKVSSKVLLSAVTENTYLMKL-MDPLLYEYAG--- 82

  Fly    93 LQNKEMYPPYKPFKIALT-----------KDGAISHVVFKEGDPIWSMNFKRAIASVLQFQM-KS 145
            ...|:.:.|......||.           .:|.:..|....|.....||..|.|.::||..: |:
Zfish    83 TWPKDSFVPATKLTSALAAQLQIPIKFEYANGVVGKVFAPAGVSPTVMNLHRGILNILQLNLKKT 147

  Fly   146 SGAFVVDELGIHGTCRTEYFVSN--RTNYISIRKTPEVKTCK---------PYSE--AVHTTRSN 197
            ...:.:.|.|..|.|||.|.::.  :||:|.:.|:.::..|:         .|:|  |..|.|..
Zfish   148 QNIYELQEAGAQGVCRTHYVINEDPKTNHIIVTKSKDLSHCQERIMKDVGLAYTERCAECTKRVK 212

  Fly   198 VPPNTCEFDH-----QKSVIIGN---EAIYGMSPHNETGYYLSMAHAKGTTLIHTFEST------ 248
            ....|..:::     ....:|..   |.:|..||.||. :..:|..||.|......|.|
Zfish   213 SLIETATYNYIMKPADNGALIAEATVEEVYQFSPFNEI-HGAAMMEAKQTLAFVEIEKTPVVPFK 276

  Fly   249 ------GEAQF-INSELLLNFLNETPIDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQET 306
                  |..|: ..:|:|     :|||                 :|.::.
Zfish   277 ADYMHRGSLQYEFATEIL-----QTPI-----------------QLMKIS--------------- 304

  Fly   307 LIAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQETIR 371
                     |:.|:.:|..:...:...|....|     :.:.|..|.:|.|   :.|..:.|.|.
Zfish   305 ---------DAPAQIVEVLKHLVANNKDMVHDD-----APLKFVQLVQLLR---VATLEKIEAIW 352

  Fly   372 NIFH----------EIIPRIGTKASV-FLTHHLVLNKLTKPQIAVQLLIPM-----PFHIFELSA 420
            :.|.          :.:|.:||...: |:....:..:.|.|:....|:|.:     .....:::|
Zfish   353 SQFKDKPVYRRWLLDALPAVGTPVIIKFIKEKFLAGEFTTPEFIQTLVIALQRVSADLETIQMTA 417

  Fly   421 ELVQKCEDFLNIGPDRPDVRQAAILSFATLIHNVYVAKGIDKEKFEEYVQKYFNAYLSDRDFDQK 485
            .|... |.|..:    |.:|:.|:|.:.:||....:|......:....:.:.....:|..|..:.
Zfish   418 SLAMH-EKFSTV----PALREVAMLGYGSLIARHCIAVPTCPAELLRPIHEIATEAVSKNDIPEI 477

  Fly   486 MLYLQGLNNL--------------QLGNVANYLEPIVQDPNEHEDLKFQAAWTTLALADRRAERI 536
            .|.|:.:.|.              .|...||.|...||         ..|......:|.:..:.:
Zfish   478 TLALKVMGNAGHPSSLKPIMKLLPGLRTAANALPVRVQ---------VDAILALRNIAKKEPKLV 533

  Fly   537 YEVYWPIFESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETT 601
            ..:...:...|....|:|:.|..:|..:.|:.|.:.|:...:::|.:.|:.::..:.:.|::..|
Zfish   534 QPIALQLVLDRALHPEVRMVACIVLFEAEPSVALISSLAGALRTEPNMHVASFAYSHIKSLTRIT 598

  Fly   602 YPCYQHLRRLLSYMHRHLPQKPES-RYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMPVVAF 665
            .|...::....:...:.:..|.:. .|..:..:..||..:...|||....:::.|..:.:|....
Zfish   599 APDMAYVAGAANVAIKLMNCKLDRLNYRYSRAFKMDYYYTPLMIGAAGSAYMINDAATILPRAVV 663

  Fly   666 FKFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFTFKSIKALLAMLQAPIINSKDLHL 730
            .|......|.....:...::..|:.:.:|....:....|..|  .||..|..|    .|.|.|..
Zfish   664 AKARAYLAGAAADVVEFGVRTGGIHEALLKSPAADESVDRIT--KIKRTLRAL----TNWKALPT 722

  Fly   731 EFILQMEGKTVLSYYLNQRMF-RQLTYDN----ILERMQQIIRTDSHINMQTVRWPFMNRYTVPT 790
            :       |.:.|.|:  ::| :::.|.|    |:|.                        .:|.
Zfish   723 D-------KPLASAYV--KVFGQEVAYVNFDKTIIEE------------------------AIPM 754

  Fly   791 VLGTSSDVLLQTTVLTSLRGNITEQRNSP--------ITKHTLEIDARYSSY-ASVRSRSYN 843
            |.|.....||: ..|.:|:..|..|...|        |....:.:...:|.| |:|.:.|.|
Zfish   755 VTGPKPRALLK-EALKALQEGIAFQYAKPLLAAEVRRILPTAVGVPMEFSWYTAAVAAASVN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	125/636 (20%)
		DUF1943	632..>813	CDD:286281	35/185 (19%)
		VWD	1277..1435	CDD:295339
vtg4	NP_001038759.2	Vitellogenin_N	24..592	CDD:279663	125/642 (19%)
		DUF1943	626..917	CDD:286281	45/230 (20%)
		DUF1944	1166..1330	CDD:286284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581660
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850