DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and vtg5

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_001020360.2	Gene:	vtg5 / 64260	ZFINID:	ZDB-GENE-001201-4	Length:	1358	Species:	Danio rerio

Alignment Length:	909	Identity:	176/909 - (19%)
Similarity:	325/909 - (35%)	Gaps:	213/909 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NKQMLYEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNNSGEKF 92
            :|..:|:||. :|:|..||:...:|    |..|..|:.|...:|......| :|.:....:|..
Zfish    27 DKTYVYKYEA-LLLGGLPQEGLARA----GIKVSSKVHLSAMTENTYLMKL-MDPLLYEYAGTW- 84

  Fly    93 LQNKEMYPPYKPFKIALTK------------------DGAISHVVFKEGDPIWSMNFKRAIASVL 139
                    |..|| :..||                  :|.:..|....|.....||..|.|.::|
Zfish    85 --------PRDPF-VPATKLTSALAAQLQIPIKFEYANGVVGKVFAPAGVSPTVMNLYRGILNIL 140

  Fly   140 QFQM-KSSGAFVVDELGIHGTCRTEYFVSN--RTNYISIRKTPEVKTCK---------PYSE--A 190
            |..: |:...:.:.|.|..|.|||.|.::.  :||:|.:.|:.::..|:         .|:|  |
Zfish   141 QLNLKKTQNIYEMQEAGAQGVCRTHYVINEDPKTNHIIVTKSKDLSHCQERIMKDVGLAYTERCA 205

  Fly   191 VHTTRSNVPPNTCEFDH-----QKSVIIGN---EAIYGMSPHNETGYYLSMAHAKGTTLIHTFES 247
            ..|.|......|..:::     ....:|..   |.:|..||.||. :..:|..||.|......|.
Zfish   206 ECTKRVKSLIETATYNYIMKPADNGALIAEATVEEVYQFSPFNEI-HGAAMMEAKQTLAFVEIEK 269

  Fly   248 T------------GEAQF-INSELLLNFLNETPIDNPIDIETSMAAEPSNLELQRLDPNDPTGGR 299
            |            |..|: ..||:|     :||                 |:|.::..
Zfish   270 TPVVPIKADYMPRGSLQYEFASEIL-----QTP-----------------LQLMKIKD------- 305

  Fly   300 SPQQQ----ETLIAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVD 360
            :|.|.    :.|:|....::.      :...|||.:        :::||.....:.:..::.:..
Zfish   306 APAQTVEVLKHLVANNKDMVH------DDAPFKFVQ--------LVQLLRVATLEKIEAIWSQFK 356

  Fly   361 IGTSYRQETIRNIFHEIIPRIGTKASV-FLTHHLVLNKLTKPQ------IAVQLLIPMPFHIFEL 418
            ....||:..:     :.:|.:||...: |:....:..:.|.|:      ||:| ::.......::
Zfish   357 DKPVYRRWLL-----DALPAVGTPVIIKFIKEKFLAGEFTTPEFIQTLVIALQ-MVTADIETIQM 415

  Fly   419 SAELVQKCEDFLNIGPDRPDVRQAAILSFATLIHNVYVAKGIDKEKFEEYVQKYFNAYLSDRDFD 483
            :|.|... |.|.:|    |.:|:..:|.:.:||.....|......:....:.:.....:|..|..
Zfish   416 TASLATH-EKFASI----PALREVVMLGYGSLIAKHCTAVPTCPAELLRPIHEIATEAISKNDIP 475

  Fly   484 QKMLYLQGLNNL--------------QLGNVANYLEPIVQDPNEHEDLKFQAAWTTLALADRRAE 534
            :..|.|:.:.|.              .|...||.|...||         ..|......:|.:..:
Zfish   476 EITLALKVMGNAGHPSSLKPIMKLLPGLRTAANALPVKVQ---------VDAILALRNIAKKEPK 531

  Fly   535 RIYEVYWPIFESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISE 599
            .:..|...:...|....|:|:.|..:|..:.|:.|.:.|:...:::|.:.|:.::..:.:.|::.
Zfish   532 LVQPVALQLVLDRALHPEVRMVACIVLFEAEPSVALISSLAGALRTEPNMHVSSFAYSHIKSLTR 596

  Fly   600 TTYPCYQHLRRLLSYMHRHLPQKPES-RYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMPVV 663
            .|.|....:....:...:.:..|.:. .|..:..:..||..:...|||....:::.|..:.:|..
Zfish   597 ITAPDMASVAGAANVAIKLMNCKLDRLNYRYSRAFHMDYYYTPLMIGAAGSAYMINDAATILPRA 661

  Fly   664 AFFKFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFTFKSIKALLAMLQAPIINSKDL 728
            ...|......|.....:...::..|:.:.:|....:....|..|  .||..|..|    .|.|.|
Zfish   662 VVAKARAYLAGAAADVIEFGVRTGGINEALLKSPAAEESVDRIT--KIKRTLKAL----TNWKAL 720

  Fly   729 HLEFILQMEGKTVLSYYLNQRMFRQ----LTYD-NILERMQQIIRTDSHINMQTVRWPFMNRYTV 788
            ..:       :.:.|.|.  ::|.|    :.:| :|:|.                        .:
Zfish   721 PTD-------RPLASAYF--KVFGQEVAYVNFDKSIIEE------------------------AI 752

  Fly   789 PTVLGTSSDVLLQTTVLTSLRGNITEQRNSP--------ITKHTLEIDARYSSY-ASVRSRSYN 843
            |.|.|.....||: ..|.:|:..|..|...|        |....:.:...:|.| |:|.:.|.|
Zfish   753 PMVTGPKPRALLK-EALKALQEGIAFQYAKPLLAAEVRRIFPTAVGVPMEFSWYTAAVAAASVN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	127/638 (20%)
		DUF1943	632..>813	CDD:286281	34/185 (18%)
		VWD	1277..1435	CDD:295339
vtg5	NP_001020360.2	Vitellogenin_N	24..592	CDD:279663	127/644 (20%)
		DUF1943	626..917	CDD:286281	44/230 (19%)
		DUF1944	1166..1330	CDD:286284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581663
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850