DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and vtg8

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	XP_021325376.1	Gene:	vtg8 / 560066	ZFINID:	ZDB-GENE-091106-1	Length:	1553	Species:	Danio rerio

Alignment Length:	1670	Identity:	290/1670 - (17%)
Similarity:	571/1670 - (34%)	Gaps:	500/1670 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIFDAGHAFSIIGLNKQMLYEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAAL 78
            ||..|.....::.|:...|:||.     |..|:|.          .|..|.||:      |||.|
Zfish    65 LIIAADDNIFLLKLSNPQLFEYS-----GIWPEDT----------FVTSKFTLE------LAAQL 108

  Fly    79 VIDDVTLNNSGEKFLQNKEMYPPYKPFKIALTKDGAISHVVFKEGDPIWSMNFKRAIASVLQFQM 143
            .|                       |.|...| :|.:..:......|...:|..|.|.::.|..:
Zfish   109 QI-----------------------PIKFEYT-NGMVGKLFIPSLVPTIVINLYRGILNIFQLNL 149

  Fly   144 -KSSGAFVVDELGIHGTCRTEYFVS--NRTNYISIRKTPEVKTC--------------------- 184
             |:...:.:.|.||.|.|:|:|.:|  ...|:.:|.|:.::.:|
Zfish   150 KKTQNVYEIQEDGIQGICKTQYVISEDEENNHTTIIKSKDLTSCHKRIMKDVGLSYLEKCIECQQ 214

  Fly   185 --KPYSEAVHTTRSNV---PPNTCEFDHQKSVIIGNEA----IYGMSPHNETGYYLSMAHAKGTT 240
              |.||.||  |.|.:   .||        .|:| .||    |:..:|..|.|         ..|
Zfish   215 KIKSYSGAV--TYSYILKPAPN--------GVMI-TEATVREIHQFTPQYEIG---------DAT 259

  Fly   241 LIHTFESTGEAQFINSELL---LNFLNETPIDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQ 302
            .:.|.::....:.:.::::   .::|....:......||..    |.::|.::..
Zfish   260 QMETRQTLTFLEIMTTDIIPISADYLARGTLQYEFSTETLW----SPIQLMKISD---------- 310

  Fly   303 QQETLIAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDF---DSLTKLYREVDIGTS 364
                  |||     .:.:||.....|..|.::......|.|:..|.|   |::..::.:.....:
Zfish   311 ------AQA-----QIVDALNNLATKKKEVHEDVPLKYIHLIQLMRFASVDAVEGIWSQFKTRPN 364

  Fly   365 YRQETIRNIFHEIIPRIGTKASV------FLTHHLVLNKLTKPQIAVQLLIPMPFHIFEL--SAE 421
            :|:..:     :.||.:||.|::      ||...|..::.|:..:....::.......::  |..
Zfish   365 FRKWIL-----DAIPAVGTLAALKFIKKTFLAGELSFSEFTQVLLVAVHMVTANLDTIKMYSSLA 424

  Fly   422 LVQKCEDFLNIGPDRPDVRQAAILSFATLIHNVYVAKGID-KEKFEEYVQKYFNAYLSDRDFDQK 485
            |..|.:       :.|.:|:.|:|.:.|:|.. |.:..:: ..:..:::.:......:..|..:.
Zfish   425 LHHKVQ-------ETPVLREIAMLGYGTMIAR-YCSGALECPVELLKHIHEIATKVSAKADIAEI 481

  Fly   486 MLYLQGLNN----LQLGNVANYLEPIVQDPNEHEDLKFQ--AAWTTLALADRRAERIYEVYWPIF 544
            .|.|:.|.|    ..:..:..:| ||.........::.|  |..|..|||.:.::::..|...:|
Zfish   482 TLILKVLGNAAHPASIKYITKFL-PIFGTHIHQFPMRVQVDAILTLKALAKKESKQVLNVVLQLF 545

  Fly   545 ESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETTYP------ 603
            .:::...|||:.:..::..:.|:...:|::.|.::||.:..:.::..:.:.:::.:|.|
Zfish   546 LNKDLHPELRMLSWIVIFETKPSMGLVITLARGLRSEKNLQVSSFAYSHMKALARSTAPDFALIA 610

  Fly   604 --CYQHLRRL------LSYMHRHLPQKPESRYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDM 660
              |...::.|      ||:::        |:.::...|.:...|     ||....|.:.|..:.:
Zfish   611 IACNVAIKILSPKLDKLSFLY--------SKAFLLDGYTYPLMD-----GAAASAFFINDATTIL 662

  Fly   661 PVVAFFK------------FDTEALGKFTGQLALYIKAR--GLPDTILNKMQSRNGSDPFTFKSI 711
            |.|...|            |:..:.|   ..:.||:..|  |:.:.:|..........|    :|
Zfish   663 PRVVVAKVHAYLAGAAADVFEVSSSG---DTILLYVGIRTDGIQEVLLKSPFLNEDGQP----TI 720

  Fly   712 KALLAMLQAPIINSKDLHLEFI-LQMEGKTVLSYYLNQRMFRQ----LTYDNILERMQQII-RTD 770
            :.|...|::....||..|:..| :::.|:.:....:::.:..|    .|..:::|.:::.: :..
Zfish   721 RQLFQALKSFKTLSKKQHIGSIYIKLFGQEIAFANVDKAVLEQAIQFTTEGHMVELIEEALKKMQ 785

  Fly   771 SHINMQTVRWPFMN--RYTVPTVLGTSSDVLLQTTVLTSLRGNITEQR--NSPITK-----HTLE 826
            :.|..|..:...|.  |:..|:..|...::.|....:.:  ||:..|.  ..|:|:     |.::
Zfish   786 NGIVFQYAKPLLMGEVRHIFPSAAGVPMELSLYAAAVVA--GNLNVQAIITPPLTELTSVAHLMK 848

  Fly   827 IDARY-------------------------SSYASVRSRSYNPF-----LNLDHEINREQGFLIY 861
            .|.:.                         :|.|..:..:..|.     .::.|...:.|.|.|.
Zfish   849 TDVKVTAEISPSIALQAFAVAGINTGFIQAASIARGKIHTLMPLKVVGKFDITHANFKLQTFPIA 913

  Fly   862 IPFSSELHLNESGSKCRRYSFSRPQNLTSGLSFKSRAVTKTRGLITKTAAAPFEE---------- 916
            .|..:......:...|..: |:....:.:.|.|...:     ...|.:||...|:
Zfish   914 FPVHAVTAQYVTVHSCLHH-FTTVYLINNILCFLFNS-----SFETLSAAGNIEDVNAQIIKPTL 972

  Fly   917 ---IMVPEGRNDVVQLFS----------YPMTD-------------------LGVRLSM------ 943
               ::|...:|.:..:.|          .|:.|                   :|::..|
Zfish   973 PKMVVVQSSQNTLTSIISPGALSSEPVMPPVKDPELRSIVPVHKTLCSVIPHIGIKTCMEVLSCN 1037

  Fly   944 ------TTNLNELIKYRGMLLKSEFTENGFSGNMVVNALMYIFGFTQLSSIHL------------ 990
                  ||..|.:.::.|:.|:.:.      |......|:     .::::::|
Zfish  1038 AAFIKNTTLYNMIGQHGGLELEVQL------GARAAKKLL-----KEINNVYLKTPKIKTILQKL 1091

  Fly   991 -----GHDRNFTMLMYNEKNTRIEGNFCAEDVLKTSDMKGKQIGLTLEHTDHMNENHA-ADALHR 1049
                 |..|:.:...:|.|..:|..:........:|.:.        :...|::|..: .|::..
Zfish  1092 REILEGRKRDKSSRFFNHKKIQIAPSSSRRSFSSSSSVH--------DSISHLSETRSLVDSVPP 1148

  Fly  1050 WNITLD--VLASTKSNWFKLTGQVQR-NSKDD--------EDDWKACTKLTYEPLVFTKRPHTLN 1103
            ....:.  |....|...::||..|.| ||:..        :|:||.|.    :.::.:|:  |:.
Zfish  1149 VVAIIGRVVRVDHKLLGYQLTAYVDRPNSRVQMIVVSIAAKDNWKMCA----DAVLMSKQ--TIV 1207

  Fly  1104 GDVVFGLATEESECPEKGSTVQFAARAGPSEHARAFLRSDKISLTDTDFCPKEVLKFSPIPTSRY 1168
            ..:.:|..:.:.....||.|    ...|||                    |...||
Zfish  1208 AKMAWGAESPKYAITIKGGT----GHHGPS--------------------PMVYLK--------- 1239

  Fly  1169 CKRSNFENFTSITQYDMDLKFDNMPAWFELWSNRLDHLVSALSADKVDSLHMSQEINISMQTP-- 1231
                              :|.:.:|.:...:|..:...:.  .|.::..|.:|.|.||..|..
Zfish  1240 ------------------VKCEKVPRFITAYSKSVAGYIP--GAAEMTGLTISNEKNIERQIELI 1284

  Fly  1232 ---QDQFRLAVEVNGVKWRFHQIPFFYKLDSKFDASHELTFDSGLK-----------RSCSVING 1282
               ||...|.:.:........:......:...|:|..|   |:.:|           ..||.:..
Zfish  1285 ILVQDLRTLDIIIKTPLMTLSKTNLVLPIALPFEAYPE---DNVIKMIQNLYKEASSAKCSKVRS 1346

  Fly  1283 IVNTFDDYLINLREIAVRPDCLTLLVADCSPLPQIAVFVTPSPV---QGLSTNYG-LRVHIGQNY 1343
            |:.||:....|. ||.:  ....:||.||:...:..:.:....|   :.||.... :.|.:.|..
Zfish  1347 ILTTFNHRTYNC-EIPL--SFYQVLVQDCTSEHKFLILMKKDDVYKHEVLSIKVADIAVQLYQQD 1408

  Fly  1344 FNFRARTDNSSLPTDEPVLIYLNQDQTPHNVRKKPYQWPIETSDYDFRVE--------------L 1394
            ...:.|.:.:.:.||                 |.||..|..|    ..:|              |
Zfish  1409 SVIKVRINGTEVTTD-----------------KIPYHHPTGT----IHIEKKGAGIAFYAPGHGL 1452

  Fly  1395 NEQNILIVECTQLSSTIQFDLYNILNFEIY--GVYKHQMCGLCSK 1437
            ||.                 .|....:|||  ...|.|..|:|.|
Zfish  1453 NEV-----------------YYAADQWEIYVGDRMKGQTRGICEK 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	117/614 (19%)
		DUF1943	632..>813	CDD:286281	37/202 (18%)
		VWD	1277..1435	CDD:295339	36/177 (20%)
vtg8	XP_021325376.1	Vitellogenin_N	34..596	CDD:279663	121/634 (19%)
		DUF1943	631..911	CDD:312626	48/301 (16%)
		DUF1944	1148..1312	CDD:312629	37/222 (17%)
		VWD	1349..1492	CDD:214566	35/173 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581661
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850