DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-d and vtg7

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_001096141.1	Gene:	vtg7 / 559856	ZFINID:	ZDB-GENE-001201-6	Length:	1358	Species:	Danio rerio

Alignment Length:	1126	Identity:	208/1126 - (18%)
Similarity:	380/1126 - (33%)	Gaps:	321/1126 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NKQMLYEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNNSGEKF 92
            :|..:|:||. :|:|..||:...:|    |..|..|:.|...:|......| :|.:....:|
Zfish    27 DKTYVYKYEA-LLLGGLPQEGLARA----GIKVSSKVLLSAMTENTYLMKL-MDPLLYEYAG--- 82

  Fly    93 LQNKEMYPPYKPFKIALT-----------KDGAISHVVFKEGDPIWSMNFKRAIASVLQFQMKSS 146
            ...|:.:.|......||.           .:|.:..|....|.....||..|.|.::||..:|::
Zfish    83 TWPKDPFVPATKLTSALAAQLQIPIKFEYANGVVGKVFAPAGVSPTVMNLYRGILNILQLNLKTT 147

  Fly   147 -GAFVVDELGIHGTCRTEYFVSN--RTNYISIRKTPEVKTCK---------PYSEAVH--TTRSN 197
             ..:.:.|.|..|.|||.|.::.  :||:|.:.|:.::..|:         .|:|:..  |.|..
Zfish   148 QNIYELQEAGAQGVCRTHYVINEDPKTNHIIVTKSKDLSHCQERIMKDVGLAYTESCPECTERVK 212

  Fly   198 VPPNTCEFDH-----QKSVIIGN---EAIYGMSPHNETGYYLSMAHAKGTTLIHTFEST------ 248
            ....|..:::     ....:|..   |.:|..||.||. :..:|..||.|......|.|
Zfish   213 SLIETATYNYIMKPADNGALIAEATVEEVYQFSPFNEI-HGAAMMEAKQTLAFVEIEKTPVVPIK 276

  Fly   249 ------GEAQF-INSELLLNFLNETPIDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQET 306
                  |..|: ..:|:|     :|||                 :|.::.
Zfish   277 ADYMPRGSLQYEFATEIL-----QTPI-----------------QLMKIS--------------- 304

  Fly   307 LIAQAGTLLDSLAEALETTEFKFSEPYDSTLSD-------VIKLLSEMDFDSLTKLYREVDIGTS 364
                     |:.|:.:|......:...|....|       :::||.....|....::.:......
Zfish   305 ---------DATAQIVEVLTHLVANNKDMVHDDAPLKFVQLVQLLRLSTLDKFEAIWAQFKNKPV 360

  Fly   365 YRQETIRNIFHEIIPRIGTKASV-FLTHHLVLNKLTKPQIAVQLLIPMPFHIFELSAELVQKC-- 426
            ||:..:     :.:|.:||...: |:....:..:.|.|:....|::.:.....:|  |.:|..
Zfish   361 YRRWLL-----DALPAVGTPVIIKFIKEKFLAGEFTTPEFIQTLVVALQMVTADL--ETIQMTYS 418

  Fly   427 ----EDFLNIGPDRPDVRQAAILSFATLIHNVYVAKGIDKEKFEEYVQKYFNAYLSDRDFDQKML 487
                |.|..|    |.:|:..:|.:.:||....||......:..:.:.:.....:|..|..:..|
Zfish   419 LATHEKFTTI----PALREVVMLGYGSLIAKHCVAVPSCPAELLKPIHEITAEAISKNDIPEITL 479

  Fly   488 YLQGLNNLQLGNVANYLEPIVQDPNEHEDLKFQAAWTTLA-----------------LADRRAER 535
            .|:.:.|  .|:.:: |:||         :|......|.|                 :|.:..:.
Zfish   480 ALKVMGN--AGHPSS-LKPI---------MKLLPGLRTAANALPIKVQVDAILALRNIAKKEPKL 532

  Fly   536 IYEVYWPIFESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISET 600
            :..:...:...|....|:|:.|..:|..:.|:||.:.|:...::.|.:.|:.::..:.:.|::..
Zfish   533 VQPIALQLVLDRALHPEVRMVACIVLFEAKPSAALVSSLAGALRIEPNMHVASFAYSHIKSLTRI 597

  Fly   601 TYPCYQHL----RRLLSYMHRHLPQKPESRYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMP 661
            |.|....:    ...:..|:|.|.:   ..|..:..:..||..:...|||....:::.|..:.:|
Zfish   598 TAPDMASVAGAANVAIKLMNRKLDR---LNYRYSRAFHMDYYHTPLMIGAAGSAYMINDAATILP 659

  Fly   662 VVAFFKFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFT--FKSIKAL---------- 714
            .....|..|...|.....:...::..|:.:.:|....:....|..|  .:::|||
Zfish   660 RAIVAKARTYLAGAAADVIEFGVRTGGIHEALLKSSAADESVDRITKIKRTLKALANWKALPTDR 724

  Fly   715 -LAMLQAPIINSKDLHLEF---------------------------------------ILQMEGK 739
             ||.....:...:..::.|                                       :|..|.:
Zfish   725 PLASAYVKVFGQEVAYVNFDKTIIEEAIPMVSGPKPRALLKEALKALQEGVAFQYAKPLLAAEVR 789

  Fly   740 TVL----------SYY--------LNQRMFRQLTYDNILERM--QQIIRTDSHINMQTVRWPFMN 784
            .:|          |.|        :|.:..........||.|  .|:.|||  :..|....|.:.
Zfish   790 RILPTAVGVPMEFSLYTAAVAAASVNVQATITPALPEKLESMTLDQLKRTD--VQFQAEARPSVA 852

  Fly   785 RYTVPTVLGTSSDVLLQTTVLTSLRGNITE------QRNSPITK-----HTLEID-------ARY 831
            ..|. .|:|.:: ..:|..|:.  ||.|..      ...:.|.|     .||.::       |.:
Zfish   853 LQTF-AVMGVNT-AFIQAAVMA--RGKIRTIAPGKVAARADILKGNYKVETLPVELPEHIASASF 913

  Fly   832 SSYASVRSRSYNPFLNLDHEINREQGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTSG-LSFK 895
            .:.|.||:..       ||...|.      ||...||.|..|            |..::| ||.:
Zfish   914 ETLAVVRNIE-------DHSAERS------IPLVPELSLQNS------------QTSSAGDLSTE 953

  Fly   896 SRAVTKTRGLITKTAAAPFEEIMVPEGRNDVVQLFSYPMTDLGVRLSMTTNLNELIKYRGMLLKS 960
            ..:....|      |:|||:..:          .:|.|...:       ....|:..|....:|:
Zfish   954 MSSAASVR------ASAPFDRTL----------CYSCPYIQV-------KGCVEVHSYNAAFIKN 995

  Fly   961 EFTENGFSGNMVVNALMYIFG 981
                         :.|.||.|
Zfish   996 -------------STLFYIIG 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	123/637 (19%)
		DUF1943	632..>813	CDD:286281	42/252 (17%)
		VWD	1277..1435	CDD:295339
vtg7	NP_001096141.1	Vitellogenin_N	24..592	CDD:279663	123/643 (19%)
		DUF1943	626..917	CDD:286281	48/296 (16%)
		DUF1944	1164..1328	CDD:286284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581662
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840