DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and vtg1

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_001038362.3	Gene:	vtg1 / 559475	ZFINID:	ZDB-GENE-001201-1	Length:	1362	Species:	Danio rerio

Alignment Length:	1104	Identity:	200/1104 - (18%)
Similarity:	377/1104 - (34%)	Gaps:	333/1104 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLKCSVFVYLFLIFDAGHAFSIIGLNKQMLYEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQ 67
            |:.|..|   .|:.:..|       :|..:|:||. :|:|..|| ||         :.|..:
Zfish    12 LVACQQF---NLVPEFAH-------DKTYVYKYEA-LLLGGLPQ-EG---------LARAGI--- 52

  Fly    68 RQSELVLAAALVIDDVTLNNSGEKFLQNKEMYP-----PYKPFKIALTK---------------- 111
            :.|..||.:|      |..|:....|.:..:|.     |..|| :..||
Zfish    53 KVSSKVLISA------TTENTYLMKLMDPLLYEYAGTWPKDPF-VPATKLTSALAAQLQIPIKFE 110

  Fly   112 --DGAISHVVFKEGDPIWSMNFKRAIASVLQFQM-KSSGAFVVDELGIHGTCRTEYFVSN--RTN 171
              :|.:..|....|.....||..|.|.::||..: |:...:.:.|.|..|.|||.|.::.  :.|
Zfish   111 YANGVVGKVFAPAGVSPTVMNLHRGILNILQLNLKKTQNIYEMQEAGAQGVCRTHYVINEDPKAN 175

  Fly   172 YISIRKTPEVKTCK---------PYSE--AVHTTRSNVPPNTCEFDH-----QKSVIIGN---EA 217
            :|.:.|:.::..|:         .|:|  |..|.|......|..:::     ....:|..   |.
Zfish   176 HIIVTKSKDLSHCQERIMKDVGLAYTERCAECTERVKSLIETATYNYIMKPADNGALIAEATVEE 240

  Fly   218 IYGMSPHNETGYYLSMAHAKGTTLIHTFEST------------GEAQF-INSELLLNFLNETPID 269
            :|..||.||. :..:|..||.|......|.|            |..|: ..:|:|     :|||
Zfish   241 VYQFSPFNEI-HGAAMMEAKQTLAFVEIEKTPVVPIKADYMPRGSLQYEFATEIL-----QTPI- 298

  Fly   270 NPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQETLIAQAGTLLDSLAEALETTEFKFSEPYD 334
                            :|.::.                        |:.|:.:|..:...|...|
Zfish   299 ----------------QLMKIS------------------------DAPAQIVEVLKHLVSNNKD 323

  Fly   335 STLSD-------VIKLLSEMDFDSLTKLYREVDIGTSYRQETIRNIFHEIIPRIGTKASV-FLTH 391
            ....|       :::||.....:.:..::.:......||:..:     :.:|.:||...: |:..
Zfish   324 MVHDDAPFKFVQLVQLLRVASLEKIEAIWSQFKDKPVYRRWLL-----DALPAVGTPVIIKFIKE 383

  Fly   392 HLVLNKLTKPQ------IAVQLLIPMPFHIFELSAELVQKCEDFLNIGPDRPDVRQAAILSFATL 450
            ..:..:.|.|:      ||:|::...| ...:::|.|... |.|..|    |.:|:..:|.:.:|
Zfish   384 KFLAGEFTTPEFIQTLVIALQMVTADP-ETIKMTASLATH-EKFATI----PALREVVMLGYGSL 442

  Fly   451 IHNVYVAKGIDKEKFEEYVQKYFNAYLSDRDFDQKMLYLQGLNNLQLGNVANYLEPIVQDPNEHE 515
            |....||......:....:.:.....:|..|..:..|.|:.:.|  .|:.:: |:||
Zfish   443 IAKYCVAVPTCPAELLRPIHEIATEAISKNDIPEITLALKVMGN--AGHPSS-LKPI-------- 496

  Fly   516 DLKFQAAWTTLA-----------------LADRRAERIYEVYWPIFESRNASLELRVAAVTLLLI 563
             :|......|.|                 :|.:..:.:..|...:...|....|:|:.|..:|..
Zfish   497 -MKLLPGLRTAANALPIRVQVDAILALRNIAKKEPKLVQPVALQLVLDRALHPEVRMVACIVLFE 560

  Fly   564 SNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETTYPCYQHLRRLLSYMHRHLPQKPES-RY 627
            :.|:.|.:.|:...::.|.:.|:.::..:.:.|::..|.|....:....:...:.:.:|.:. .|
Zfish   561 AEPSVALVSSLAGALRIEPNMHVASFAYSHIKSLTRITAPDMASVAGAANVAIKLMSRKLDRLNY 625

  Fly   628 WVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMPVVAFFKFDTEALGKFTGQLALYIKARGLPDT 692
            ..:..:..||..:...|||....:::.|..:.:|.....|......|.....:...::..|:.:.
Zfish   626 RYSRAFQMDYYYTPLMIGAAGSAYMINDAATILPRAVVAKARAYLAGAAADVIEFGVRTGGIHEA 690

  Fly   693 ILNKMQSRNGSDPFT--FKSIKAL-----------LAMLQAPIINSKDLHLEF------------ 732
            :|....:...:|..|  .::::||           ||.....:...:..::.|
Zfish   691 LLKSPAADESADRITKIKRTLRALTNWKALPTDKPLASAYLKVFGQEVAYVNFDKTIIEEAIPMA 755

  Fly   733 ---------------------------ILQMEGKTVL----------SYY--------------- 745
                                       :|..|.:.:|          |:|
Zfish   756 TGPKPRALLKEALKALQEGVAFQYAKPLLAAEVRRILPTAVGVPMEFSWYTAAVAAASVNVQATI 820

  Fly   746 ---LNQRMFRQLTYDNILERMQQIIRTDSHINMQTVRWPFMNRYTVPTVLGTSSDVLLQTTVLTS 807
               |.::: ..:||       :|:.:||  :..|....|.:...|. .|:|.:: ..:|..|:.
Zfish   821 TPALPEKL-ESMTY-------EQLKKTD--VQFQAEARPSVALQTF-AVMGVNT-AFIQAAVMA- 872

  Fly   808 LRGNITE------QRNSPITKHTLEID------------ARYSSYASVRSRSYNPFLNLDHEINR 854
             ||.|..      ...:.|.|...:::            |.:.:||.||:..       ||...|
Zfish   873 -RGKIRTIAPGKVAARADILKGNYKVEALPVELPEHIASASFETYAVVRNIE-------DHSAER 929

  Fly   855 EQGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTSGLSFKSRAVTKTRGLITKTAAAPFEEIM 918
            .      :|...||.|..|.:           :....||.:..:|...|      |.|||:..:
Zfish   930 S------VPLVPELSLQNSQA-----------SYAGDLSSEMSSVASVR------APAPFDRTL 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	128/649 (20%)
		DUF1943	632..>813	CDD:286281	38/260 (15%)
		VWD	1277..1435	CDD:295339
vtg1	NP_001038362.3	Vitellogenin_N	24..592	CDD:279663	129/665 (19%)
		DUF1943	626..917	CDD:286281	42/304 (14%)
		DUF1944	1168..1332	CDD:286284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581664
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850