DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and apobb.1

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	XP_005160686.1	Gene:	apobb.1 / 321166	ZFINID:	ZDB-GENE-030131-9732	Length:	3739	Species:	Danio rerio

Alignment Length:	2067	Identity:	367/2067 - (17%)
Similarity:	635/2067 - (30%)	Gaps:	821/2067 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PFKIALTKDGAISHVVFKEGD-PIWSMNFKRAIASVLQFQMKSSGAFVVDE------LGIHGTCR 161
            |.|..:..|..|.  :|.|.| |...:||||.:.|.|       .|.|::|      ..::|.||
Zfish   113 PLKFTVEGDNDIK--LFPENDEPANILNFKRGLISAL-------AAPVLEEDRNRRMPTVYGMCR 168

  Fly   162 TEYFVSNR----TNYISIRKTPEVKTCKPYSEAV-HTT----------------RSNVPPNTC-- 203
            |:|.|:.|    |:.:..|   ::..|..:|... ||:                ||:   .||
Zfish   169 TDYSVNARQDIATDVVLNR---DLSNCDKFSPVKDHTSPLALITGMQYPLAQLIRSS---QTCNY 227

  Fly   204 EFDH-----------QKSVI-------------IGNEA--IYGMSPHNETGYYLSMAHAKGTTLI 242
            :||:           :|.::             :|.:|  :.|:|.:|...:..:.|:.|...|.
Zfish   228 KFDNDQKHMTSASCSEKHMLLPFSYKGEHGVSNVGKQALTLVGVSVYNGRIFDHNEANMKTLHLD 292

  Fly   243 HTFESTGEAQFINSELL----LNFLNET--------------PIDNPIDIETSMAAEPSNLELQR 289
            .:.:|....|..::.|.    ||.|:||              .....:..|:..||.|..||:.|
Zfish   293 DSIDSVHPIQDKDAILSILRDLNDLSETTNGENRAHLAHKLISTIRKMSAESLSAALPEALEISR 357

  Fly   290 -------LDPNDP-----------TGGRSPQQQETLIAQAGTL----LDSLAEALETTEFKFSEP 332
                   .....|           |..||..:.:..:...|.:    .|.:.|.||..:||.|:|
Zfish   358 PLVYQALFQCGTPECTSAILRVLRTFDRSSVEIDAAVYAMGMVPNPSRDLVEEMLEMAKFKSSKP 422

  Fly   333 YDSTLSDVIKLLSEMDFDSLT-------------------------------------------- 353
            ....||:.:|.|.|:: .|:|
Zfish   423 IYYALSNAVKRLYEVE-KSVTPEIKAVADYTLEQIGDCTGNQEHVYLSLRVIGNMAAAVGAASPA 486

  Fly   354 -----------------------KLYREVDIGTSYRQETIRNIFHEIIP---RIGT--------- 383
                                   :::|...:....|:..::.||.:..|   |:..
Zfish   487 LKSAVIQCINQPAASPEVQQAAIQVFRLTSVPDEGREVLMKVIFDKAAPIQKRVAAYLIVMKDPQ 551

  Fly   384 -----------------KASVFLTHHL-----------------VLNKLTKPQIAV--------- 405
                             :|..|:..||                 :||.|...:|:.
Zfish   552 PTELAQLVAALPNNKNCQAMSFVNSHLRNILSSTTSETGELRVKILNALQGNEISTSTDPTKFSR 616

  Fly   406 ---------------------QLLIPMPFHIFELSAELVQ------------------------K 425
                                 ::::.|..:.|....::.:                        .
Zfish   617 NYKIGSLEGNVIFESEELLPNEVILEMTLNAFGYDVDMFEIGLNGKGLEPTVDALIGIDGFFRDT 681

  Fly   426 CEDFLNIGPDR----PDVRQAAILSFATLIHNVYVAK---GIDKE---KFEEYVQKYFNAYLSDR 480
            .:..:|...|:    .|:.|:   .|.||.:|:.:.|   .|.||   ...:.:||     |..:
Zfish   682 MQKTINYAADKVPRGNDIMQS---MFPTLWNNIKMQKAPQSIVKEITNNVNKLIQK-----LKVQ 738

  Fly   481 DFDQKMLYLQGLNNLQLGNVANYLEPIVQDPNEHEDLKFQAAWTTLALADR----RAERIY---- 537
            |..:.|:||:     .||....||:     .|:.||:.:.||..|.:|.:.    ....:|
Zfish   739 DNPEAMIYLR-----LLGAEMGYLK-----TNDVEDMAYSAALLTKSLLNMFPTDFLRNLYSSVN 793

  Fly   538 ------------EVYWPIFESRNASLELRVA---------------------------------- 556
                        |.|.|    ....:.||||
Zfish   794 NNLFLHYVFMDNEFYLP----TGTGIPLRVALSGTFAPGVKGGLKLARDMSEVAFMPSAGVEFVT 854

  Fly   557 ------------------------------AVT----LLLISNP-TAARLISIHRIIQSETDPHM 586
                                          |||    .|.|..| |:.:|||:..
Zfish   855 EVGALLPEYVESGLEMHTNIYHESGLKVKVAVTNKQFKLTIPTPKTSTKLISVSN---------- 909

  Fly   587 INYYRTTVTSISETTYPCYQHLRR--------------LLSYMHR-------HLPQKPESR---- 626
             :.|..|.|.|.... |..:|::.              ::.|.:.       :.|...:|:
Zfish   910 -SLYSVTGTEIKRIP-PLAEHVKARKCTPFIPGFQYCGVMQYSNAFSNDAAPYFPLTGDSKFAIE 972

  Fly   627 ---------YWVTGNYIFDYRDS--KFGIGAMLQVF-----LVGD------------PKSDMPV- 662
                     |..|.:|.:|.:|.  .||:.|....|     |..|            |..|:..
Zfish   973 IHPTGEVSSYTATADYAYDGKDDTVTFGLKAEGITFESIVKLTFDRQNYEVSADVQIPDYDLEAG 1037

  Fly   663 VAFFKFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFTFKSIKALL------AMLQAP 721
            :.....|.:|....|..:.:.:..:.:|:..|..: ::.||.......::.|:      |.:.|.
Zfish  1038 IRVHAVDRKAQSDATHSIQIDLMKKNVPEASLIGL-AKIGSMKDAMLQVQLLIPNFETDAKVTAT 1101

  Fly   722 IINSKDLHLEF-----ILQMEG---KTVLSYYLNQRMFR------------------QLTYDNIL 760
            :.|:.:|.:|.     :.:|..   |.:|.|...:....                  :.|:::||
Zfish  1102 LKNTDELKVELESDIKLPEMTSSIQKMILKYDAEEIEAEVSSDVTTEIHNIITTDAIKATFNDIL 1166

  Fly   761 ERMQQIIRTDSHIN-----------------------MQTVRWP-----------FMN-----RY 786
            :  |:|..:|..|.                       :|.:|.|           |:|     :|
Zfish  1167 D--QEIGTSDKKIRDVLTQFVEASNAYLEQFSPNIPYVQELRIPALPEFTFPKKLFLNAEGAAKY 1229

  Fly   787 ---------TVPTVLG--TSSD----VLLQTTVLTSLRGNI-TEQRNSPI----TKHTLEIDARY 831
                     |:|..||  ||.|    ..|:|.||...:.:: .:..|.|:    ...:|.:....
Zfish  1230 KFGQNYYTITIPVPLGGKTSRDFNLPAALETPVLNVPQLDLQVKSINIPLPVFFIPESLSLSLPL 1294

  Fly   832 SSYASVRSRSYNPFLNLDHEINREQGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTS------ 890
            .:.|.|.|:..:.|.:::.:.:.          .|||....:.|.....:.:.|.:|.|
Zfish  1295 VAKAEVSSKLSSNFYDMEAKASA----------GSELVDKPTYSAMIEVTGTSPVDLLSFKIEGS 1349

  Fly   891 -------GLSFKSRAVTKTRGLITKTAAAPFEEIMVPEGRNDVVQLFSYPM---TDLGVRLSM-- 943
                   |.|.|:...:.....:.:.:...||||...|   .:....|..|   :..|:::|:
Zfish  1350 TFLVGRLGESLKTEMKSSLNHKLLEASVNYFEEITTGE---KITMKSSSKMEAKSPFGLKISLEH 1411

  Fly   944 --TTNLNE-LIKYRGMLLKSEFTENGFSGNMVVNALMYIFGF-----------TQLSSIHLGH-- 992
              ...|:| .|...|.||.| ......:|.:.:...:.:..|           ..|..|...:
Zfish  1412 TGQVGLDEDEISGDGNLLGS-IKAGPLNGEVALRQSLILLPFKPELKIDSSLKVDLEQIQAENII 1475

  Fly   993 DRNFT--MLMYNEKNTRIEGNF--CAEDVLK------TSDMKGKQIGLTLEHTDHMNENHAADAL 1047
            :..|.  .|.:..|:|..:.|.  .||...|      .||.:.|..||.::     |...|:.:.
Zfish  1476 EAAFANGELSFTSKSTAFQDNLIHVAELAYKESQLALKSDARAKAFGLNIQ-----NVAEASASF 1535

  Fly  1048 HRWNITLDV--------------LASTKSNWFKLTGQVQRNSKDDEDDWKACTKLTYEPLVFTKR 1098
            :..|:.:|.              :|:..:|...:......| .|:......|:      |..|:
Zfish  1536 NLVNVKIDTNVDTLFGNRVRSQFIAALDANGLDVKSDASAN-LDEHTASHMCS------LSLTR- 1592

  Fly  1099 PHTLNGDVVFGLATEESECPEKGSTVQ--FAARAGPS------EHARAFL-------RSDKISLT 1148
                ||.|..|  :...|||:...|:|  |......|      |....|:       .|...||:
Zfish  1593 ----NGLVTIG--STLLECPDMPLTLQNKFNGALDTSGLSLSVETKGKFVEVTIENTNSLSASLS 1651

  Fly  1149 DTDFCPKE-----------VLKFSPIPTSRYCKRSNFENFTSITQYDMDLKFDNMPAWFEL---W 1199
            ..||..|.           .|:..|..||  .|.||..|..:|...: :.:|..:|...:|   |
Zfish  1652 SVDFISKANSDDGTYVHDFSLQLQPYSTS--LKISNNLNALNIKLIN-EAQFKALPYAADLTGSW 1713

  Fly  1200 --SNRLDHLVSALS--------------ADKVDSLHMSQEINISMQTPQDQFRLAVEVNGVKWRF 1248
              |:..|.|.:...              ..|:...||||...|.:......:......|....||
Zfish  1714 KLSSGTDELKNTYEIKYEDLVATAKCGLTGKLMGSHMSQNTEIEVAGLSVTYGSESNFNSQYLRF 1778

  Fly  1249 HQ------IPFFYKLDSKFDASHELTFDSGLKRSCSV--------------------INGIVNTF 1287
            :.      :||.:.:|:..:|..:|....  |:|..|                    ::...|.:
Zfish  1779 NSDLHAAAVPFRFNVDAMVNADGDLYLYG--KQSAQVYSKFLMKAEPLAFAHSHECRVSTTYNLY 1841

  Fly  1288 DDYLINLREIAVRPDCLTLLVADCSPLPQIAVFVTPSPVQGLSTNYGLRVHIGQNYFNFRARTDN 1352
            ||                 ||.:.:...:|...:|||..:.       .|.:...:.|.....|.
Zfish  1842 DD-----------------LVFETNLDNKIDTVLTPSEQKA-------TVRVKSKFNNHEFNKDL 1882

  Fly  1353 SSLPTDEPVLIYL---------------NQD-------QTPHNVRKKPYQWP-IETSDYDFR--- 1391
            |:..|.|.:.:.:               |||       :...|...:....| |:...:|.:
Zfish  1883 SAYNTPERLGVEMSGSIITNIFNTVDSDNQDHFFSAFLKYDKNSNSRALSLPFIDEFPFDLQHMK 1947

  Fly  1392 ------VE-----LNEQNILIVECTQLSSTIQFDLYNILN---------------FEIYGVYKHQ 1430
                  ||     :|.:.| |||..:|::.:. |..|.||               :|.||:....
Zfish  1948 LAVLRIVEAMQSYINREEI-IVEIQKLATYVS-DFVNELNLEEKIIKFSKDLTALYEDYGITLDD 2010

  Fly  1431 M-CGLCS-KP-----LNRMQNYTICELE--------ANTPTPVPLQNSSDVV 1467
            : ..|.: ||     :..:..|.: |:|        :.||:...:|..:|::
Zfish  2011 LEASLMNLKPVLLKLVTELDTYVV-EIEKIVREIITSGTPSDAAIQRFTDIL 2061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	144/846 (17%)
		DUF1943	632..>813	CDD:286281	52/287 (18%)
		VWD	1277..1435	CDD:295339	38/230 (17%)
apobb.1	XP_005160686.1	Vitellogenin_N	32..579	CDD:279663	89/481 (19%)
		DUF1943	613..912	CDD:286281	50/331 (15%)
		DUF1081	934..1016	CDD:283982	13/81 (16%)
		EzrA	1921..2312	CDD:283753	29/144 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810