DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and vtg3

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_571340.1	Gene:	vtg3 / 30518	ZFINID:	ZDB-GENE-991019-2	Length:	1253	Species:	Danio rerio

Alignment Length:	1321	Identity:	258/1321 - (19%)
Similarity:	457/1321 - (34%)	Gaps:	358/1321 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LNKQMLYE--YEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNNSG 89
            ||.:..||  |||.|.|       |.:.|......::.:.|.:...|......|.:.:|..
Zfish    24 LNSKKTYEYKYEGLVQV-------GRELPHLVESALKLRCTFKIIGESPHTFVLQVSNVDF---- 77

  Fly    90 EKF--LQNKEMYPPYKPFKIALTKD-----------GAISHVVFKEGDPIWSMNFKRAIASVLQF 141
            |.|  :..|.::.|.|.....|:.:           |.|:.:....|.....:|..|.|...||.
Zfish    78 EDFNGIPGKSVFSPSKNITKHLSAEISQPIIFEYSKGQITDIRTAPGVSNTVVNIVRGILGFLQV 142

  Fly   142 QMKSSGAFV-VDELGIHGTCRTEYFVSNRTN---------------------YISIRKTPEVKTC 184
            .:|::.:|. :.||||||.|::.|.|...:|                     |..:...||.|..
Zfish   143 TVKTTQSFYELIELGIHGLCQSSYTVDEDSNAKELIVTRIVDITNCQQPASLYRGMALAPEDKLS 207

  Fly   185 KPYSEAV-------HTTRSNVPPNTCEFDHQKSVIIGNEAIYGMSPHNETGYYLSMAHAKGTTLI 242
            |...|:|       :|.:|.....      |.:.....|..| .||.|..|....|...:...|:
Zfish   208 KQRGESVVSTVKHTYTVKSTADGG------QITKAFAQERQY-FSPFNVKGGNFRMLALRDIELL 265

  Fly   243 HTFESTGEAQFINSELLLNFLNETPID-NPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQET 306
            ...::|.:......:...|.:.:|..| .||.:             ..|:.|||.    |:
Zfish   266 KVSDTTDKVVTGQVQSRGNLMYKTNKDLKPIPV-------------VMLNLNDPV----PK---- 309

  Fly   307 LIAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQ---E 368
                   :||.:....:...:.......:.:.|:|:|:.....|:|..|:::|.....:|:   :
Zfish   310 -------ILDLIKRLAQANIYHVDSETSTEILDLIQLMRVTTLDNLEHLWKQVSGNDEHRRWFLD 367

  Fly   369 TIRNIFHEIIPRIGTKASVFLTHHLVLNKLTKPQIAVQLLIPMPFHIFELSAE--LVQKCEDFLN 431
            .:..:..|.|.:       ||........:|..:....|::...    .||||  .|...::||.
Zfish   368 LVVEVTDERILK-------FLEARYKAGDITANEAGQALVVAFN----HLSAEPVSVALAQEFLT 421

  Fly   432 I--GPDRPDVRQAAILSFATLIHNVYVAKGIDKEKFEEY--------VQKYFN---AYLSDRDFD 483
            |  ....|.:....:|::.:|:|...|           |        ||...|   :.||....|
Zfish   422 IPFSKSHPLLWNTVVLAYGSLVHRYCV-----------YTDPCPITVVQPLLNMAASSLSKNSED 475

  Fly   484 QKMLYLQGLNN-LQLGNVANYLEPIVQDPNEHEDLKFQ----AAWTTLALADRRAERIYEVYWPI 543
            :.:|.|:.|.| ..|.:....|:.:....|..|.|..:    |......||.|.:..:.::...:
Zfish   476 EMVLALKSLGNAAHLSSFKTLLKFLPGYSNGAEKLSTRVQGAAVQAFRLLASRASHSVQDIVLNL 540

  Fly   544 FESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETTYPCYQHL 608
            |..::...|:|:.|..:||.:.|:.|.:..:..::..|.|..:.::..:.:...:::..|..|||
Zfish   541 FVQKHLPAEIRMLACIVLLETKPSTALISVVSEVLLEEADLQVASFSYSLLKGFAKSRTPDNQHL 605

  Fly   609 -------RRLLSYMHRHLPQKPESRYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPKSDMPVVAFF 666
                   .::|:....||      .|..:.|..||:....|..|....|:::.: :|.:|.....
Zfish   606 SIACNIAMKILTRKLGHL------SYRYSKNLHFDWFHDDFLFGTSADVYMLQN-ESPIPTKLML 663

  Fly   667 KFDTEALGKFTGQLALYIKARGLPDTILNKMQSRNGSDPFTFKSIKALLAMLQAPIINSKDLHLE 731
            |.....:|:....|...|:|.||.|....|:...  :.......:.::|.:|.    |.:.|
Zfish   664 KGKFHFIGRILQFLEFGIRADGLKDLFAGKIPEL--TKDLGISDLASILKILS----NWQSL--- 719

  Fly   732 FILQMEGKTVLSYYLNQRMFRQLTY--DNILERMQQIIRT-------DSHI--NMQTVR------ 779
                .:.|.:|:.|  .|:|.|..:  |...:.:|.||::       :|.:  .:|.|:
Zfish   720 ----PKDKPLLTAY--ARVFGQEAFLMDVSRDSVQSIIKSFSPSAGKESKVWERIQDVQKGTSWH 778

  Fly   780 WP-----FMNRYTVPTVLGTSSDVLLQTTVLTSLRGNITEQRNSPITKHTLEIDARYSSYASVRS 839
            |.     :..|:..||.||...::....:|:.::......:.|.|..:|..|:   .||..|:::
Zfish   779 WTKPHLVYEARFIQPTCLGLPVEISKYYSVVNAVTMKAKAEINPPPKEHLGEL---LSSDISMQT 840

  Fly   840 RSY-----NPFLNLDHEINRE---------QGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTS 890
            ..:     :.|  |.|.||.:         ....:.:|::.:|.:|.. .:....:.:..:::|.
Zfish   841 DGFIGVTKDHF--LFHGINTDLFQCGTELKSKVSMGLPWAFDLKINPK-EQTYEMNLTPSKSVTE 902

  Fly   891 GLSFKSRAVTKTRGLITKTAA--APFEEIMVPEGRNDVVQLFSYPMTDLGVRLSMTTNL-NELIK 952
            ..|..|......|.:...|::  .|    |:||...      |:.    ||.|.|...| :|..|
Zfish   903 LFSVSSNVYAVLRNIEDPTSSKITP----MMPETGE------SWQ----GVPLRMLPPLRDEQTK 953

  Fly   953 YRGMLLKSEFTENGFSGNMVVNA------------LMYIFGFTQLS---------------SIHL 990
            ..||..:.......:...:.:.|            |.|:.|.|..|               .|.:
Zfish   954 KSGMKFRQCAEAKIYGTALCIEAEAKRAHYLHEYPLYYLLGDTHFSYSLEPAKDAKPIEKIQIQV 1018

  Fly   991 GHDRNFTMLM-----YNE---KNTRIEGNFCAE-----------DVLKTSD-----------MKG 1025
            ...|....:|     .|:   |.||.|...|.|           |:..|.|           .:.
Zfish  1019 SASRQHPSVMSGMVNLNQRVFKETRDENTSCEERKTSSSLPVTQDLDVTPDPVVTVKALSLSPQA 1083

  Fly  1026 KQIGL--------TLEHTD--------------------HMNENHAADALH-RW-------NITL 1054
            |.:|.        |.:..|                    |.::.|.:...| ||       ::::
Zfish  1084 KPLGYEGVAFYLPTAQKDDIEMIVSEVGEEANWKMCANAHFDKTHTSAKAHLRWGAECQTYDVSM 1148

  Fly  1055 DVLA----------STKSNW------FKLTGQVQRNSKDDEDDWKACTKLTYEPLVFTKRPHTLN 1103
            .|.|          |||.||      |...||:.:.               |.|.|
Zfish  1149 RVSAACQPESKPSISTKINWGTLPSVFTTVGQIVQE---------------YVPGV--------- 1189

  Fly  1104 GDVVFGLATEESECPEKGSTV 1124
             ..:.|...::.|.||:.::|
Zfish  1190 -SYIMGFYQKKEENPERQASV 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	128/628 (20%)
		DUF1943	632..>813	CDD:286281	41/202 (20%)
		VWD	1277..1435	CDD:295339
vtg3	NP_571340.1	Vitellogenin_N	24..592	CDD:279663	129/635 (20%)
		DUF1943	626..912	CDD:286281	59/307 (19%)
		DUF1944	1070..1238	CDD:286284	27/165 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581668
Domainoid	1	1.000	54	1.000	Domainoid score	I11190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950