DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and Apob

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	NP_033823.2	Gene:	Apob / 238055	MGIID:	88052	Length:	4505	Species:	Mus musculus

Alignment Length:	1801	Identity:	335/1801 - (18%)
Similarity:	592/1801 - (32%)	Gaps:	607/1801 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 VRGKLTLQRQSELVLAAALVIDDVTLNNSGEKFLQNKEMYPPYKPFKIALTKDGAISHVVFKEGD 124
            |.|||.|.....|.....:|:..:...:..:.||                       |.:|.:.
Mouse   794 VLGKLLLSGAQTLQGIPQMVVQAIREGSKNDLFL-----------------------HYIFMDN- 834

  Fly   125 PIWSMNFKRAIASVLQFQMKSSGAFVVDELGIHGTCRTEY----------------FVSN----- 168
                 .|:....:.||.|:.|||.|..   ||....|.|.                ||:|
Mouse   835 -----AFELPTGAGLQLQVSSSGVFTP---GIKAGVRLELANIQAELVAKPSVSLEFVTNMGIII 891

  Fly   169 ----------RTNY-----ISIR---KTPEVKTCKPY----------SEAVH---TTRSNVPPNT 202
                      .||:     :..|   |..::|...|.          |..:|   ||::.|.|..
Mouse   892 PDFAKSSVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLFSGSNTLHLVSTTKTEVIPPL 956

  Fly   203 CEFDHQKSVIIGNEAIYGMSPHNETGYYLSMAHAKGTTLIHTFESTGEAQFINSELLLNFLNETP 267
            .|  :::|.........||: :..||.|   ::|..|.....:..||:.::
Mouse   957 VE--NRQSWSTCKPLFTGMN-YCTTGAY---SNASSTESASYYPLTGDTRY-------------- 1001

  Fly   268 IDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQET----LIAQAGTLLDSL-----AEALE 323
                            .|||:      || |...|...|    |:.:..:|:|:|     ||.::
Mouse  1002 ----------------ELELR------PT-GEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQ 1043

  Fly   324 TTE----FKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQETIRNIFHEIIPRIGTK 384
            .:|    ||::....:..|:|:....:::|.::.::..|     |.:.:....:..:|..:..|:
Mouse  1044 QSEATVLFKYNRRSRTLSSEVLIPGFDVNFGTILRVNDE-----SAKDKNTYKLILDIQNKKITE 1103

  Fly   385 ASVFLTHHLVLNKLTKPQIAVQLLIP-------MPFHIFELSAELVQKCEDFLNIGPDRPDVR-- 440
            .|  |..||..:|....:|...:.||       ...|....|.:|:.:.:............|
Mouse  1104 VS--LVGHLSYDKKGDGKIKGVVSIPRLQAEARSEVHTHWSSTKLLFQMDSSATAYGSTISKRVT 1166

  Fly   441 ---QAAILSF----ATLIHNVYVAKG--IDKEKFEEYVQKYFNAYLSD---------RDFDQKML 487
               ...|:.|    .|.:....||..  :|...:...:.:|.|..|..         ||...|::
Mouse  1167 WRYDNEIIEFDWNTGTNVDTKKVASNFPVDLSHYPRMLHEYANGLLDHRVPQTDVTFRDMGSKLI 1231

  Fly   488 Y-------------------------LQGLNNLQLG------------------------NVANY 503
            .                         |..||.|::|                        |..|.
Mouse  1232 VATNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPDNLFLKTDGRVKYTMNRNKINI 1296

  Fly   504 LEPIVQDPNEHEDLKFQAAWTTLALADRRA-----ERIYEVYWPIFESRNASLELRVAAVTLLLI 563
            ..|:.......:|||...:..|.||..:..     .|  ||..|.|...... :|:|..:.:|.:
Mouse  1297 DIPLPLGGKSSKDLKMPESVRTPALNFKSVGFHLPSR--EVQVPTFTIPKTH-QLQVPLLGVLDL 1358

  Fly   564 SNPTAARL----------------ISIHRIIQSETDPHMINYYRTTVTSISETTY--------PC 604
            |....:.|                .|:....:.:|| .:::.:..:|....||||        .|
Mouse  1359 STNVYSNLYNWSASYTGGNTSRDHFSLQAQYRMKTD-SVVDLFSYSVQGSGETTYDSKNTFTLSC 1422

  Fly   605 YQHLRRLLSYMHRHLPQK------------PESRYWVTGNYIFDYRDSKFGIGAMLQVFLVGDPK 657
            ...|.      |:.|..|            |.|:..:|       .::...:|..:...:..|.|
Mouse  1423 DGSLH------HKFLDSKFKVSHVEKFGNSPVSKGLLT-------FETSSALGPQMSATVHLDSK 1474

  Fly   658 -------SDMPVVAFFKFDT-EALGKF---------TGQLALYIKARGLPDTILNKMQSRNGSDP 705
                   .|:.|...|:..: .|.||:         ||||:      |..:...|...
Mouse  1475 KKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLS------GESNMRFNSTY------- 1526

  Fly   706 FTFKSIKALLAMLQ---APIINSKDLHLEFILQMEGKTVLSYYLNQRMFRQLTYDNI-------- 759
              |:....::.|.|   ..|.::.||..............:|.|..:......|:|.
Mouse  1527 --FQGTNQIVGMYQDGALSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFAASNKLDV 1589

  Fly   760 -LERMQQIIRTDSHINMQTVRWPFMNRYTVPTVLG---TSSDVLLQTTVLTSLRGNITEQRNSPI 820
             ......::|::...|.:::|        :.|:|.   ||..|.|...:|.      |::.|:..
Mouse  1590 TFSTQSALLRSEHQANYKSLR--------LVTLLSGSLTSQGVELNADILG------TDKINTGA 1640

  Fly   821 TKHTLEIDARYSSYASVRSRSYNPFLNLDHEINREQGFLIYIPFSSELHLNESGSKCRRYSFSRP 885
            .|.||:|.....|.::..:..|:|.| |::|:|.|.|.              ||:..:..:..|.
Mouse  1641 HKATLKIARDGLSTSATTNLKYSPLL-LENELNAELGL--------------SGASMKLSTNGRF 1690

  Fly   886 QNLTSGLSFKSRAVTKTRGLITKTAAAPFEEIMV--PEGRNDVVQLFSYPMTDLGVRLSMTTNLN 948
            :...:..|...||.      :|:.:.....:.|:  .:.:|    :|::.::..|:|||     |
Mouse  1691 KEHHAKFSLDGRAA------LTEVSLGSIYQAMILGADSKN----IFNFKLSREGLRLS-----N 1740

  Fly   949 ELI-KYRGMLLKSEFTENGFSGNMVVNALMYIFGFTQLSSIHLG---HDRNFTM----------- 998
            :|: .|..|.|....:.|       :..|...| |:::.:|:.|   :.:||.:
Mouse  1741 DLMGSYAEMKLDHTHSLN-------IAGLSLDF-FSKMDNIYSGDKFYKQNFNLQLQPYSFITTL 1797

  Fly   999 ---LMYNEKNTRIEGNFCAEDVLKTS---DMKG-------KQIGLTLEHTDHMNENHAADAL--- 1047
               |.|...:....|.|..|. ||.:   :.||       |.| .|:.:||.:..::.||.:
Mouse  1798 SNDLRYGALDLTNNGRFRLEP-LKLNVGGNFKGTYQNNELKHI-YTISYTDLVVASYRADTVAKV 1860

  Fly  1048 ------HRWNI-------TLDVLASTKSN-------------------------------WFKLT 1068
                  ||.|.       ::||..|..|:                               |.:.|
Mouse  1861 QGVEFSHRLNADIEGLTSSVDVTTSYNSDPLHFNNVFHFSLAPFTLGIDTHTSGDGKLSFWGEHT 1925

  Fly  1069 GQVQRN--SKDD------EDDWKACT--KLTYEPLVFTKRPHTLNGDVVFGLATEESECPEKGST 1123
            ||:...  .|.:      ..|:|..|  .|.||..:.|...||     |..|.|.    .|:.||
Mouse  1926 GQLYSKFLLKAEPLALIVSHDYKGSTSHSLPYESSISTALEHT-----VSALLTP----AEQTST 1981

  Fly  1124 VQFAARAGP---SEHARAFLRSDKISLTDTDFCPKEVLKFSPIPTS-RYCKRSNFEN-------- 1176
            .:|..:...   |:...|:...|||.:..:.......| :|||... .|.:..|..|
Mouse  1982 WKFKTKLNDKVYSQDFEAYNTKDKIGVELSGRADLSGL-YSPIKLPFFYSEPVNVLNGLEVNDAV 2045

  Fly  1177 -----FT--SITQYD--MDLKFDNMPAWFELWSNRLDH----LVSALSADK-------VDSL--- 1218
                 ||  ::.:||  .|:...|:| :|:...:.|:.    ::|.|.|.:       ||..
Mouse  2046 DKPQEFTIIAVVKYDKNQDVHTINLP-FFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQFVRK 2109

  Fly  1219 ------HMSQEINISMQTP----------------QDQFRLA-----VEVNGVKWRFHQIPFFYK 1256
                  .:.|:|:..:...                .:.:|:.     :.::..|..|::     |
Mouse  2110 YRAALSRLPQQIHHYLNASDWERQVAGAKEKITSFMENYRITDNDVLIAIDSAKINFNE-----K 2169

  Fly  1257 LDS------KFDASHELTFD-SGLKRS-CSVINGIVNTF----DDYLINLREIAVRPDCLTLLVA 1309
            |..      :||...:..:| ..|||: ..:|:.|:...    :.|.|.: .:|.....|.|.|.
Mouse  2170 LSQLETYAIQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRV-NLAKSIHNLYLFVE 2233

  Fly  1310 DCSPLPQIAVFVTPSPVQGLSTNYGLRVHIGQNYFNFRARTDNSSLPTDEPVLIYLNQDQTPHNV 1374
            :.. |.|::...| |.:|.:.:||.:|:.|.:.....|.:..|            ::..|....|
Mouse  2234 NVD-LNQVSSSNT-SWIQNVDSNYQVRIQIQEKLQQLRTQIQN------------IDIQQLAAEV 2284

  Fly  1375 RKKPYQWPIETSDYDFRVELNEQNILIVECTQLSSTIQFDLYNILN------------------F 1421
            :::     ::..|....::.....||....:.:...:::.:.|::.                  .
Mouse  2285 KRQ-----MDAIDVTMHLDQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELI 2344

  Fly  1422 EIYGVYKHQMCGLCSKPLNRMQNYTICELEANTPTPVPLQNSSDVV 1467
            |.|.|.:|... |..|.:.....|::.|         |||..|:|:
Mouse  2345 EKYEVDQHIQV-LMDKSVELAHRYSLSE---------PLQKLSNVL 2380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	124/690 (18%)
		DUF1943	632..>813	CDD:286281	35/212 (17%)
		VWD	1277..1435	CDD:295339	29/179 (16%)
Apob	NP_033823.2	Heparin-binding. /evidence=ECO:0000250	32..126
		Vitellogenin_N	46..597	CDD:279663
		Heparin-binding. /evidence=ECO:0000250	232..306
		DUF1943	632..944	CDD:286281	33/181 (18%)
		Heparin-binding. /evidence=ECO:0000250	902..959		13/58 (22%)
		DUF1081	961..1062	CDD:283982	27/141 (19%)
		Heparin-binding. /evidence=ECO:0000250	2042..2177		21/140 (15%)
		Heparin-binding. /evidence=ECO:0000250	3155..3230
		Basic (possible receptor binding region). /evidence=ECO:0000250	3168..3178
		LDL receptor binding. /evidence=ECO:0000250	3368..3388
		Heparin-binding. /evidence=ECO:0000250	3378..3511
		Basic (possible receptor binding region). /evidence=ECO:0000250	3381..3389
		ApoB100_C	4434..4490	CDD:289274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810