Protein Alignment cv-d and vit-1

DIOPT Version :9

• Sequence 1: NP_732076.1
• Gene: cv-d / 41921
• FlyBaseID: FBgn0265048
• Length: 1470
• Species: Drosophila melanogaster
• Sequence 2: NP_001367671.1
• Gene: vit-1 / 181034
• WormBaseID: WBGene00006925
• Length: 1616
• Species: Caenorhabditis elegans
• Alignment Length: 1667
• Identity: 331/1667 - (19%)
• Similarity: 596/1667 - (35%)
• Gaps: 480/1667 - (28%)

  Fly    33 YEYEGNVLVGAKPQDEGHQAPPTTGWIVRGKLTLQRQSELVLAAALVIDD-------VTLNNSGE 90
            |:::|.||.|.          ||..    .:|:..|.|..|...|  :||       |.::.:..
 Worm    32 YKFDGLVLSGL----------PTAS----SELSQSRFSARVRIQA--VDDRHIHLQLVNIHMAAS 80

  Fly    91 KF-----------LQNKEMYPPYK-----PFKIALTKDGAISHVVFKEGDPIWSMNFKRAIASVL 139
            ..           ::.:|:...||     |.:..| ::|.|:.:.|.:.|..||.|.|||:.:::
 Worm    81 HLPESEQIPSLNSMEQRELSEEYKQMLKLPLRAQL-RNGLIAELQFDKEDAEWSKNMKRAVVNMI 144

  Fly   140 QF--------------------QMKSSGAFVVDELGIHGTCRTEYFVSNRTNYISIRKTPEVKTC 184
            .|                    |.:.:.:|..:|..:.|.|:..|.|........|.|:.....|
 Worm   145 SFNPIAPRNEIEKIESSYDKEEQSEENTSFFTNEKTLEGDCQVAYTVIREQKKTIITKSINFDKC 209

  Fly   185 KPYSEAVHTTRSNVPPNTCEFDHQKSVIIGNEAIYGMSPHNE---------------TGYYLSMA 234
            ...||..:..|.:.....||.|   :|:|..:.:|.....||               .|..:...
 Worm   210 TERSEIAYGLRYSSECPECEKD---TVLIRPQTVYTYILENEELKESEVRSLYTVNVNGQEVMKT 271

  Fly   235 HAKGTTLI---HTFES-----TGEAQFIN-----SELLLNF-----------LNETPIDNPIDIE 275
            ..:...::   |:.:|     .||.:.|.     .:|:.:|           ..:.|:|..:.:.
 Worm   272 ETRSKLVLEENHSIKSHIEKVNGEKESIIYSSRWEQLVEDFFKNGDKAEFAPFEKFPLDKKMHLI 336

  Fly   276 TSMAAEPSNLELQRLDPNDPTGGRSPQQQETLIAQAGTLLDSLAEALETTEF--KFSEPYDSTLS 338
            .::..     ::|.::.|.|                           ||:.|  :....:.:|.:
 Worm   337 KTITE-----QIQEVENNIP---------------------------ETSHFLARLVRIFRTTST 369

  Fly   339 DVIKLLSEMDFDSLTKLYREVDIGTSYRQETIRNIFHEIIPRIGTKASV--FLTHHLVLNKLTKP 401
            ..:|.:.|       .||.:.|       :.|:::....:...|||.::  .|.|  :.|:...|
 Worm   370 SQLKEIHE-------TLYVKAD-------KKIQSLMEHALAIAGTKNTIQHILVH--IENEDIVP 418

  Fly   402 QIAVQLLIPM---PFHIFELSAELVQKCEDFLNIGPDRPDVRQAAILSFATLIHNVYVAKGI--- 460
            ..|.|||..:   ||....::..|::..|.  .:..:...|||:|.|:..:::..:...|.|
 Worm   419 LEAAQLLKSIQETPFPSQTIAEALIKFAES--RVSKNNQVVRQSAWLAAGSVVRGIVDYKNIRPL 481

  Fly   461 ---DKEKF-EEYVQKYFNAYLSDRDFDQKMLYLQGLNNLQLGNVANYLEPIVQDPNEHEDLKFQA 521
               ||.:. |::::.:...|.......:|:|.|:.:.|..|....|.|..|:.|..:...::.:|
 Worm   482 VREDKRELKEKFLRVFMQQYKDAETTYEKILALKSIGNAGLDISVNQLNEIIVDKRQLLPVRKEA 546

  Fly   522 AWTTLALADRRAERIYEVYWPIFESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHM 586
            ......|.|....:|.:|..||:::|....|:|:.|:..::.:.|..:.|:.:...::.||:..:
 Worm   547 IDALRLLKDTMPRKIQKVLLPIYKNRQYEPEIRMLALWRMMHTRPEESLLVQVVSQMEKETNQQV 611

  Fly   587 INYYRTTVTSISETTYPCYQHL----RRLLSYMHRHLPQKPESRYWVTGNY----IF---DYRDS 640
            .......:...:::|.||||.:    .::||:. |:.||:    ..:..:|    :|   .:..:
 Worm   612 AALTHQMIRHFAKSTNPCYQRVAIVCSKVLSFT-RYQPQE----QMIASSYAQLPLFLQNSFSGA 671

  Fly   641 KFGIGAMLQ--VFLVGDPKSDMPVV---------AFFKFDTEALGKFTGQLAL------------ 682
            :|...|:.:  .||:.|..:.:..|         |...|..:.:.|:. |:||
 Worm   672 QFDFAAIFEKNSFLLKDLHASLDAVFGGNWNKYFAQIGFSQQHMDKYV-QMALEKLESIEKESTT 735

  Fly   683 YIKARGLPD--TILN----KMQSRNGSDPFTFKSIKALLAMLQAPIINSKDLHLEFI---LQMEG 738
            .::.|.:..  |:|.    ||..|  :.|..:.. |...||:   .:..||:....:   .|:..
 Worm   736 VVRGRRIQTGITLLKELALKMNIR--ARPANYNE-KDAFAMV---YLRYKDMDYAILPVDTQLIE 794

  Fly   739 KTVLSYYLNQRMFRQLTYDNILERMQQIIRTDSHINM----------QTVRWPFMNRYTVPTVLG 793
            |.:..|..|.:    :.:..|...:.|....::|...          .|:..|.:....:|||..
 Worm   795 KLIEKYISNGK----VQFSEIRRLLNQEHEFETHHAAYFYEAIRKFPTTLGLPLIVSGKIPTVFS 855

  Fly   794 TSSDVLLQTTVLTSLRGNITEQRNSPITKHTLEI-------DARYSSYASVRSRSYNPFLNLDHE 851
            ......|.... |.||..: |.|.|....|..|:       :....|..||  |:|.| :.:...
 Worm   856 AEGQFSLGLEE-TELRLTV-EARPSVAATHVYEMRMFTPLFEQGVKSVQSV--RAYTP-IKIQAV 915

  Fly   852 INREQGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTSGLSFKSRAVTKTR--GLITKTAAAPF 914
            :..::.|.|.                  |....|:|..|.:|..:|.|...|  | .:|......
 Worm   916 VGMKRNFEIV------------------YKVVVPENQKSIISLTTRPVVFLRFPG-FSKFEYIEA 961

  Fly   915 EE--IMVPEGR---NDVVQLFSYPMTDLGVRLSMTTN-LNELIKYRGMLLKSEF---TEN----- 965
            ||  ::||:.:   .::.::|::    ||:.:|...| ||:......:|.:.:|   .||
 Worm   962 EERTVVVPQWQQKTQEIEKVFNF----LGLEVSTRGNILNQHTLENWLLAEQDFEVSVENKYRPA 1022

  Fly   966 GFSGNMVVNALMYIFGFTQLSSIHLGHDRNFTMLMYNEKNTRIEGNFCAEDVLKTSDMKGKQIGL 1030
            .|:..:.|..|..    |:||.|           .||:                   :..|:..|
 Worm  1023 EFTARLTVGQLEK----TELSQI-----------KYNK-------------------IFEKEFEL 1053

  Fly  1031 TLEHTDHMNENHAADALHRWNITLDVLASTKSNWFKLTGQVQRNSKDDEDDWKACTKLTYEPLVF 1095
            ..|:|:                      |.:..:.|:...:|:     |..:|:...|..|
 Worm  1054 EQENTE----------------------SRREYFTKMVKSIQK-----EQGYKSVVSLRLE---- 1087

  Fly  1096 TKRPHTLNGDVVFGLATEESEC---------PEKGSTVQFAARAG--------PSE----HARAF 1139
            ..|.:|:|.:|......:...|         |....|.::..|:.        ||.    |.:..
 Worm  1088 APRDYTMNTEVTTVCDKQVRMCQWEVEIRRSPILEETKEWTLRSQLLVVRPEMPSSLRQLHDQPH 1152

  Fly  1140 LRSDKISLTDTDFCPK--EVLKFSPIPTSRYCK---RSNFENFTSITQYDMDLK----------- 1188
             |..::|||.|....|  ||...:.:..|:..|   |:...:|..:.:|::.:|
 Worm  1153 -REVQLSLTSTWGSQKKSEVTVNAQLQQSKEQKKYERNMDRHFNGMPEYELLIKAARLNQINAVA 1216

  Fly  1189 ---------------FDNMPAWFELW-------SNRLDHLVSALSADKVDSLHMSQEINISMQTP 1231
                           ||.:.| :..|       :|..|.:|..|:.:.:.    .|.:||:||:|
 Worm  1217 EYKLTRETEQVLARYFDLVKA-YNYWTVSSRPENNENDRVVVQLTVEPMS----RQYVNITMQSP 1276

  Fly  1232 QDQFRLAVEVNGVKWRFHQIPFFYKLDS--KFDASHELTFDSGLKRSCSVINGIVNTFDDYLINL 1294
            .::    ||:..|     |:|..| |.|  :....|.|...||  ..|.|....:.||||.|.|
 Worm  1277 IER----VELKNV-----QVPRVY-LPSIAQRSVKHLLNEASG--SVCKVQKNQIRTFDDVLYN- 1328

  Fly  1295 REIAVRPDCLTLLVADCSPLPQIAVFVTPSPVQGLSTNYGLRVHIGQNYF-------NFRARTDN 1352
               .....|.:|:..|||..|..||.  ....:..|....::|..|:...       ..|.:.|.
 Worm  1329 ---TPLTTCYSLIAKDCSEEPTFAVL--SKKTEKNSEEMIIKVIRGEQEIVAQLQNEEIRVKVDG 1388

  Fly  1353 SSLPTDEPVLIYLNQDQTPHNVRKKPYQWPIETSDYDFRVELNEQNILIVECTQLSSTIQFDLYN 1417
            ..:         |::|.:.|.:.:        ..:.|..:||.|            ..::||.|.
 Worm  1389 KKI---------LSEDYSAHQIER--------LGESDIVIELPE------------GEVRFDGYT 1424

  Fly  1418 I-LNFEIYGVYKHQMCGLCSKPLNRMQN--YTICELEANTPT 1456
            | .....|. .|:|:||||....:...|  ||    ..||.|
 Worm  1425 IKTQLPSYS-RKNQLCGLCGNNDDESTNEFYT----SDNTET 1461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	125/651 (19%)
		DUF1943	632..>813	CDD:286281	42/229 (18%)
		VWD	1277..1435	CDD:295339	37/165 (22%)
vit-1	NP_001367671.1	Vitellogenin_N	24..620	CDD:396081	125/657 (19%)
		DUF1943	655..940	CDD:401204	59/318 (19%)
		VWD	1301..1458	CDD:214566	46/198 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159772
Domainoid	1	1.000	75	1.000	Domainoid score	I5894
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I3236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14451
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.900