Protein Alignment cv-d and vit-4

DIOPT Version :9

• Sequence 1: NP_732076.1
• Gene: cv-d / 41921
• FlyBaseID: FBgn0265048
• Length: 1470
• Species: Drosophila melanogaster
• Sequence 2: NP_508612.1
• Gene: vit-4 / 180646
• WormBaseID: WBGene00006928
• Length: 1603
• Species: Caenorhabditis elegans
• Alignment Length: 1574
• Identity: 294/1574 - (18%)
• Similarity: 577/1574 - (36%)
• Gaps: 332/1574 - (21%)

  Fly    30 QMLYEYEGNVLVGAKPQDEGHQAPPTT-----GWIVRGKLTLQRQSELVLAAALVIDDVTLNNS- 88
            :.:|:::|.:|.|.          |||     ..::..:..||...:..:...|:  |:..:.|
 Worm    29 EYVYKFDGLLLSGL----------PTTFSDASQTLISCRTRLQAVDDRYIHLQLI--DIQYSASH 81

  Fly    89 ---GEKF-----LQNKEMYPPYK-----PFKIALTKDGAISHVVFKEGDPIWSMNFKRAIASVLQ 140
               .|::     |:.:|:....|     ||: |..::|.:|.:.|...|..||.|.||:|.::..
 Worm    82 IPQSEQWPKIESLEQRELSDELKELLELPFR-AQIRNGLVSEIQFSSEDAEWSKNAKRSILNLFS 145

  Fly   141 FQM-----------------KSSGAFVVDELGIHGTCRTEYFVSNRTNYISIRKTPEVKTCKPYS 188
            .:.                 |.|..|.|.|..:.|.|...|.:..........|:.....|....
 Worm   146 LRKSAPVDEMSQDQKDMESDKDSLFFNVHEKTMEGDCEVAYTIVQEGGKTIYTKSVNFDKCITRP 210

  Fly   189 EAVHTTRSNVPPNTCEFDHQKSVIIGNEAIYGMSPHNETGYYLSMAHAKGTTLIHTFESTGEAQF 253
            |..:..|.......||.:.|   .:..:.:|..:..||      .........|:|....|: :.
 Worm   211 ETAYGLRFGSECKECEKEGQ---FVQPQTVYTYTFKNE------KLQESEVNSIYTLNVNGQ-EV 265

  Fly   254 INSE--LLLNFLNETPIDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSPQQQ-------ETLIA 309
            :.||  ..:.|:.|:.|               |.|::::.        .|:::       |.||.
 Worm   266 VKSETRAKVTFVEESKI---------------NREIKKVS--------GPKEEIVYSMENEKLIE 307

  Fly   310 Q-------------AGTLLDSLAEALETTEFKFSEPYDST------LSDVIKLLSEMDFDSLTKL 355
            |             ....::...|.||....:..|...:|      ::..:::......:.|.|:
 Worm   308 QFYKQGDKAEVNPFKAIEIEQKVEQLEEIFRQIQEHEQNTPETVHLIARAVRMFRMCTIEELKKV 372

  Fly   356 YREVDIGTSYRQETIRNIFHEIIPRIGTKASV-FLTHHLVLNKLTKPQIAVQL-------LIPMP 412
            :..:   .:..::.::.:....:...|||.:: .|.||.....:| |..|.:|       |.|..
 Worm   373 HTTI---YTKAEKKVQLVIETTLAVAGTKNTIQHLIHHFEKKSIT-PLRAAELLKSVQETLYPSE 433

  Fly   413 FHIFELSAELVQKCEDFLNIGPDRPDVRQAAILS-------FATLIHNVYVAKGIDKEKFEEYVQ 470
             ||.:|..:|.|.     .:......:||:|.|:       ||:...::.:.:...::..|:||:
 Worm   434 -HIADLLIQLAQS-----PLSEKYEPLRQSAWLAAGSVVRGFASKTQDLPLIRPASRQTKEKYVR 492

  Fly   471 KYFNAYLSDRDFDQKMLYLQGLNNLQLGNVANYLEPIVQDPNEHEDLKFQAAWTTLALADRRAER 535
            .:...:.:.....:|:|.|:.|.|..:......|..::|||.:...::.:|......|.|....:
 Worm   493 VFMQHFRNADSTYEKVLALKTLGNAGIDLSVYELVQLIQDPRQPLSIRTEAVDALRLLKDVMPRK 557

  Fly   536 IYEVYWPIFESRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISET 600
            |.:|..|::::|....|||:||:..::.:.|....|..|...:::|::.|:..:....:...|::
 Worm   558 IQKVLLPVYKNRQNKPELRMAALWRMMHTIPEEPVLAHIVSQMENESNQHVAAFTYNVLRQFSKS 622

  Fly   601 TYPCYQHL----RRLLSYMHRHLPQKPE-SRY---------WVTGNYIFDYRDSKFGIGAMLQVF 651
            |.||||.|    .::|.:. |:.||:.. |.|         |::| ..||:.
 Worm   623 TNPCYQQLAVRCSKVLLFT-RYQPQEQMLSTYSQLPLFNSEWLSG-VQFDFA------------- 672

  Fly   652 LVGDPKSDMPVVAFFKFDTEALG---KFTGQLALYIKARGLPDTILNKMQSRN----GSDPFTFK 709
            .:.:..:.:|......|:|...|   |:..|:.  ...:.....||..::..:    .||....:
 Worm   673 TIFEKNAFLPKEVQASFETVFGGNWNKYFAQVG--FSQQNFEQVILKTLEKLSLYGKQSDELRSR 735

  Fly   710 SIKALLAMLQAPI-----------INSKDLHLEFILQMEGKTVLSYYLNQRMFRQLTYDNILER- 762
            .:::.:.|||..:           .:|::.|..|.|:.:....:...::..     |.||::|:
 Worm   736 RVQSGIQMLQEIVKKMNIRPRVQQTDSQNAHAVFYLRYKEMDYIVLPIDME-----TIDNVVEKY 795

  Fly   763 ----------MQQIIRTDSHINMQTVRWPFMNRYTVPTVLGTSSDVLLQTTVLTSLRGNITEQRN 817
                      :...:..||...:....:.:.....:||.:|....:..:...:.|:.|.::.:..
 Worm   796 VRNGEFDIKSLLTFLTNDSKFELHRALFFYEAERRIPTTIGMPLTISGKMPTILSINGKVSIELE 860

  Fly   818 SPITKHTLEIDARYSSYASVRSRSYNPFLNLDHEINREQGFLIYIP--FSSELHLNESGSKCRRY 880
            ....:..|:|....::......|.:.|.  ::..:...|...::.|  |.|.:.|.::..:. .:
 Worm   861 KLGARLVLDIVPTVATTHVTEMRFWYPV--IEQGVKSLQSARLHTPLRFESTVELKKNTLEI-TH 922

  Fly   881 SFSRPQNLTSGLSFKSRAVTKTRGLITKTAAAPFEEIMVPEGRNDVVQLFSYPMT---------D 936
            .|..|:|..:.:|..:|.|...|  :.|...:.:     .|.....:....|.|:         .
 Worm   923 KFVVPENKKTTVSVHTRPVAFIR--VPKNQDSEY-----VEAEEKTISHSQYQMSTEEIDRQYET 980

  Fly   937 LGVRLSMTTNLNELIKYRGMLLKS---EFT-EN-----GFSGNMVVNALMYIFGFTQLSSIHLG- 991
            .|:|::...|:........:|:..   ||| ||     .|:..:.:..|..    |.||.|...
 Worm   981 FGLRINAQGNVLSQWTLPMVLMTEQDFEFTLENKNRPVEFTARVTIGNLEK----TDLSEIKFDK 1041

  Fly   992 -HDRNFTMLMYNEKNTRIEGNFCAEDVLKTSDMKGKQIGLTLEHTDHMNENHAADALHRWNITLD 1055
             .::.|.:.....:|.|...:....::......| ..|.|.||....|          .||..|.
 Worm  1042 IFEKEFDLENNESENRRQYFHKMIREIQSEQGFK-NLITLKLEAPQQM----------YWNTELR 1095

  Fly  1056 VLASTKSNWFKLTGQVQRNSKDDED-DWKACTK-LTYEPLV------FTKRPHTLNGDVVFGLAT 1112
            .:........|:....:|:..:.|: :|...|: |...|.:      ..::||.   :|...|..
 Worm  1096 TVCDKWIRMCKVEMDARRSPIEHENKEWTLRTELLAARPQMPSSLRQLREQPHR---EVQLALNA 1157

  Fly  1113 EESECPEKGSTVQFAARAGPSEHARAFLRSDKISLTDTDFCPKEVLKFSPIPTSRY---CKRSNF 1174
            :...  .|.|.:.|.|:...|...:.|||:.:             .::..||....   ..|.|.
 Worm  1158 KWGS--SKKSEITFNAQLEQSTEQKKFLRNIE-------------REYKGIPEYELLIKAARLNQ 1207

  Fly  1175 EN------FTSITQYDMDLKFDNMPAWFELWS-------NRLDHLVSALSADKVDSLHMSQEINI 1226
            .|      .|..::|.....||.:.| :..|:       |....:|..||.:.:...:|    |:
 Worm  1208 VNVVSEYKLTPESEYTFSRIFDLIKA-YNFWTVSEKRVQNEDRRVVLQLSVEPLSRQYM----NM 1267

  Fly  1227 SMQTPQDQFRLAVEVNGVKWRFHQIPFFYKLDSKFDASHELTFDSGLKRSCSVINGIVNTFDDYL 1291
            ::|||:.:    ||:..|:.....:|...: .:.|..:.|.|     ..:|.|....|:|||:.:
 Worm  1268 TIQTPEQE----VELKNVRIPRVVLPTIAR-RAMFQQTWEKT-----GATCKVDQSEVSTFDNVI 1322

  Fly  1292 INLREIAVRPDCLTLLVADCSPLPQIAVFVTPSPVQGLSTNYGLRVHIGQNYFNFRARTDNSSLP 1356
            ..    |....|.:|:..|||..|:.||               |...|.:|......:.    :.
 Worm  1323 YR----APLTTCYSLVAKDCSEQPRFAV---------------LAKKINKNSEELLVKV----VR 1364

  Fly  1357 TDEPVLIYLNQDQTPHNVRKKPYQWPIETSDYDFRVELNEQNILIVECTQLSSTIQFDLYNILNF 1421
            .:|.:::..:.|:....|..|... |.|...|:  :|:...|::::....  ..::||.|.:...
 Worm  1365 REEEIVVKKSDDKFLVKVDGKKVN-PTELEQYN--IEILGDNLIVIRLPH--GEVRFDGYTVKTN 1424

  Fly  1422 EIYGVYKHQMCGLC 1435
            ......::|:||||
 Worm  1425 MPSVASQNQLCGLC 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	121/637 (19%)
		DUF1943	632..>813	CDD:286281	30/209 (14%)
		VWD	1277..1435	CDD:295339	33/157 (21%)
vit-4	NP_508612.1	Vitellogenin_N	24..617	CDD:279663	121/643 (19%)
		DUF1943	651..942	CDD:286281	48/314 (15%)
		VWD	1300..1454	CDD:214566	37/172 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159771
Domainoid	1	1.000	75	1.000	Domainoid score	I5894
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I3236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D25081at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14451
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.900