DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-d and apobb.2

DIOPT Version :9

Sequence 1:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster
Sequence 2:	XP_002665852.3	Gene:	apobb.2 / 100330435	ZFINID:	ZDB-GENE-070705-554	Length:	2633	Species:	Danio rerio

Alignment Length:	1648	Identity:	321/1648 - (19%)
Similarity:	549/1648 - (33%)	Gaps:	556/1648 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YEYEGNVLVGAKPQDEGHQA--------PPTTGWIVRGKLTLQRQSELVLAAALVIDDVTLNN-- 87
            |.||...|.....|..|.:|        |..:.:|:       |.::..|:....:|  |..|
Zfish    31 YFYETESLNSLNKQVNGPKASCRVEILVPDASKYIL-------RTTDCKLSEVTAVD--TEGNPV 86

  Fly    88 -----SGEKFLQNKEMYPPYKPFKIALTKDGAISHVVFKE-GDPIWSMNFKRAIASVL------Q 140
                 :.|.|..:.|.    .|.|..:|| |.|.  :|.| |:....:|.||.|.|.|      :
Zfish    87 FGKAAAAEDFRTDMEK----NPLKFTVTK-GEIR--LFPEKGERANILNIKRGIISALAVPLLEE 144

  Fly   141 FQMKSSGAFVVDELGIHGTCRTEYFVSNRTNYISIRKTPEVKTCKPYSEAVHTT----------- 194
            .:.|::.:       |:|.|.|||.|...|.....|........:|..:  ||:
Zfish   145 DRKKNTPS-------IYGLCMTEYTVDTATAVTLNRDLSRCDKFRPIED--HTSPLALITGLSHP 200

  Fly   195 -----RSNVPPNTCEF------DHQKSVIIGNEAIYGMSPHNETGYY-LSMAHAKGTTLIHTFES 247
                 |||   .||.:      :|..|.|...:.:  :.|.:..|.| ::....:..||:...|
Zfish   201 LAQLIRSN---QTCNYKFDKEQEHMTSAICTEKHV--LVPFSHKGEYGVTNTGKQVLTLLGVTE- 259

  Fly   248 TGEAQFINSELLL--NFLNETP--IDNPIDIETSMAAEPSNLELQRLDPNDPTGGRSP-QQQETL 307
                   |::.:.  |..|..|  :|..:||                         || |.:|..
Zfish   260 -------NNDRVFDHNIANMKPLHLDRSVDI-------------------------SPVQDKEAA 292

  Fly   308 IAQAGTLLDSLAEALETTEFKFSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQETIRN 372
            :|    :|..||:..:|...:........|..||:   :|:.::|.....|. :|.|      |:
Zfish   293 LA----VLRELADLYKTNSGRKRAHLAYKLVAVIR---KMEAETLRAALPEA-LGIS------RS 343

  Fly   373 IFHEIIPRIGT-KASVFLTHHLVLNKLTKPQIAVQLLIPMPFHIFELSAELVQKCEDFLNIGPDR 436
            :.::.:.:.|| |.|..:..  ::....|....|...:.....|.:.|..||::......|.|.|
Zfish   344 LTYQALLQCGTPKCSSAIMQ--IIRTFDKSSFEVDAAVYAIGIIPQTSQVLVKEMLATAKIKPSR 406

  Fly   437 PDVRQAAILSFATLIHNVYVAKGIDKEKFEEYVQKYFNAYLSDRDFDQKMLYLQGLNNLQ-LGNV 500
            |     ...:.:..:..:|...|:..|  .:.|..|....:.|...||:.::|    :|: :||:
Zfish   407 P-----IYYALSNAVRRLYETDGVTSE--IQAVADYALEQIGDCTGDQEHVFL----SLKVIGNM 460

  Fly   501 ANYL--------------------EPIVQDPNEHEDLKFQAAWTTLALADRRAERIYEVY--WPI 543
            ...|                    .|.||          |||              .:||  :|:
Zfish   461 VAALGAARPALHSAVIKCINQPGASPAVQ----------QAA--------------IQVYRQFPV 501

  Fly   544 FE-----------SRNASLELRVAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSI 597
            .|           .:.||::.||||. |:|:.|||.|.|..:...::.|.:....::..:.::||
Zfish   502 PEEGREVLMHTVLDKVASVQKRVAAY-LILMKNPTPAELAQLAAALEIEKNHEAKSFIISHISSI 565

  Fly   598 SETTYPCYQHLRRLL------SYMHRHLPQKPESRYW----VTGNYIFDYRD------------S 640
            ..:|.|...:||:.:      :.:...:.....||::    :.||:||:..|            :
Zfish   566 MASTAPETLNLRQNIQNAFQGNDIEMAMKSTQFSRHYRLGSLEGNFIFESPDNLPREVMLEMTLN 630

  Fly   641 KFGIGA-MLQVFLVGDPKSDMPVV-AFFKFD----------------------TEALGKFTGQLA 681
            .||:.. ::::.:.|  |...|:: |.|..|                      .|........|.
Zfish   631 AFGLDMDLIEIGMEG--KGFEPILEALFGEDGFFPDIVMKSILYATDKMPAELNEVWDNMLPNLN 693

  Fly   682 LYIKARGLPDTILNKMQSRNGSDPFTFKSIKALLAMLQAPIINSKDLHLEFILQMEGKTVLSYY- 745
            .|.|.|.....|:.::...........|:..|..||:...::.::   |.::...:||.:.|..
Zfish   694 NYRKKRQATQNIVKEISDSVNKLSEDLKAQDAPEAMVYLKLLGAE---LGYLDAKDGKMIGSLLK 755

  Fly   746 -----LNQRMFRQLTYDNILERMQQIIRTDSHINMQTVRWPFM-NRYTVPTVLGTSSDVLLQTTV 804
                 ..:|:|..:  ||.|                .:.:.|| |.:.:||..|....|.|..|.
Zfish   756 MIPTDFTKRLFSSV--DNEL----------------FLHYIFMDNEFYLPTAAGFPLRVALSGTF 802

  Fly   805 LTSLRGNITEQRNSPITKHTLEIDARYSSYASVRSRSYNP-------FLNLDHEINREQGFLI-- 860
            ...::|.:                            |:||       .|:...|:..|.|..:
Zfish   803 TPGIKGGL----------------------------SFNPGMGDFAFMLSAGVELVTEIGTHLPD 839

  Fly   861 YIPFSSELHLN---ESGSKCR--------RYSFSRPQNLTSGLSFKSRAVTKTRGLITKTAAAPF 914
            |:....|:|.|   |||.:.:        :.|...|:..|..:|..:..|:...|.|
Zfish   840 YVHSGLEMHTNIYHESGLRAKISGTQKRLKLSIPAPREPTELISVTNSLVSVVGGKI-------- 896

  Fly   915 EEIMVPEGRNDVVQLFSYPMTDL-----GVRLSMTT------NLNELIKYRGMLLKSEF-TENGF 967
                :|...|  ||   |.|.|.     |:: |.||      .||:...|..:...|.| .|...
Zfish   897 ----LPISAN--VQ---YTMEDCTAVFPGLK-SCTTLEYPDAALNDNAPYFPLTGDSRFAVEIRP 951

  Fly   968 SGNMVVNALMYIFGFTQLSSIHLGHDRNFTMLMYNEKNTRIEGNFCAEDV-------------LK 1019
            ||  .|.....|.|:|                 |.::..::..:..||..             |.
Zfish   952 SG--TVTEYTAIIGYT-----------------YEDEEDKLTFSVKAEGTPFEVLNTVMINRKLN 997

  Fly  1020 TSDMKGKQIGLTLEHTDHMNENHAADALHRWNITLDVLASTKSNWFKLTGQVQRNSKDDEDDWKA 1084
            |:.||.....|.|:||......:|..........|.:..:|......||.:.::...:.:..:.:
Zfish   998 TASMKLLMEALQLDHTVSGKFTNAEKLKLELQSDLKLPGTTSVQTLILTYESEKIEAEVKSHFNS 1062

  Fly  1085 CTKLTYEPLVFTKRPHTLNGD-VVFGLATEESECPEKGSTVQFAARAGPSEHARAFLRSDKISLT 1148
            .|: |..||..|       || ::.||.|.:                         :..:||.|.
Zfish  1063 KTR-TLVPLFRT-------GDTIIIGLLTRQ-------------------------MGQNKIKLL 1094

  Fly  1149 DTDFCPKEVLKFSPIPTSR--YCKRSNFENFTSITQYDM-------------------DLKFDNM 1192
            |   ...::..||.:|.:.  ......|.|..:..:|..                   ||||.
Zfish  1095 D---IIAKLAAFSGVPATLDITLPEELFLNIDAAVKYHFGQPYYTITLPLPLGGKSTRDLKFP-- 1154

  Fly  1193 PAWFELWSNRLDHLVSALSAD-----------KVDSLHMSQEINISMQTPQDQFRLAVEVNGVKW 1246
                           :.||.|           ::..:.:.:.:.:|:..    |:|| :|:| |.
Zfish  1155 ---------------TTLSTDLFIVDPDLESMQLPEVSIPESVTLSLHA----FQLA-DVSG-KL 1198

  Fly  1247 RFHQIPFFYKLD------------SKFDASHELTFDSGLKRSCSVING----------------- 1282
            |.|    .|.||            |.:.|..::|..|.:::.|..:.|
Zfish  1199 RCH----LYDLDATVSAARDPAAHSSYSAKLKVTGTSPVEQFCLQVEGSALAEATSGDSLKASMK 1259

  Fly  1283 --IVNTFDDYLINLRE-------IAVRPDC---LTLLVADCSPLPQIAVFV-TPSPVQGLSTNYG 1334
              |.:.|.:..|::.|       ::|:...   :|.|||:...:...|:|. ....:.|.....|
Zfish  1260 TVIEHKFFNATISVEEEVQSAAKLSVKSKSKLEVTSLVAEQMSVEHNAIFEGDAGQISGDGNLEG 1324

  Fly  1335 LRVHIGQNYFNFRARTDNSSLPTDEPVLIYLNQDQTPHNVRKKPYQWPIETSDYDFRVE---LNE 1396
                      :|:|.:...|....:.||:..::.:.              ..|...:|:   |..
Zfish  1325 ----------SFKAGSIYGSGNLKQSVLLIPSKQEA--------------KIDSLLKVDSKLLQA 1365

  Fly  1397 QNILIV-----ECTQLSSTIQFD 1414
            ||...|     |.|.||:|..||
Zfish  1366 QNSFSVAFANRELTVLSTTTAFD 1388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	135/640 (21%)
		DUF1943	632..>813	CDD:286281	41/223 (18%)
		VWD	1277..1435	CDD:295339	33/176 (19%)
apobb.2	XP_002665852.3	Vitellogenin_N	23..535	CDD:279663	130/618 (21%)
		DUF1943	597..889	CDD:286281	62/342 (18%)
		DUF1081	908..1001	CDD:283982	22/112 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900