Protein Alignment spn-E and DHX38

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_054722.2
• Gene: DHX38 / 9785
• HGNCID: 17211
• Length: 1227
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 203/731 - (27%)
• Similarity: 338/731 - (46%)
• Gaps: 128/731 - (17%)

  Fly     5 VMDFFD----FSKELKRVAAAPQGYISSDPRLMATK-------------FKSSEVPNRELIGTDY 52
            |..|.|    |:|:.:.|  .|....:||..::|.|             .|.::..:.||.||.
Human   413 VPPFLDGRIVFTKQPEPV--IPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHKHWELAGTK- 474

  Fly    53 VSKIVAKEKCLLNGTLLNEQPQGKRIRTLD---DLDTDDEGEETEIRRDD---EYYKKFRFNLNR 111
            :..|:..:|        .|:|.  :..|.|   |..|:.:..:...|:.:   |:.|| :..|.:
Human   475 LGDIMGVKK--------EEEPD--KAVTEDGKVDYRTEQKFADHMKRKSEASSEFAKK-KSILEQ 528

  Fly   112 DKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAI 176
            .:.|.|:|.::|:|..|..:.:||:.||||.|||||:.||:.::.|..  |..|..|||||:||:
Human   529 RQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYTD--YGMIGCTQPRRVAAM 591

  Fly   177 SIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVH 241
            |:|.||.:|..........:.:......| |:|.:.|.|.|:||...:....|.||:.|::||.|
Human   592 SVAKRVSEEMGGNLGEEVGYAIRFEDCTS-ENTLIKYMTDGILLRESLREADLDHYSAIIMDEAH 655

  Fly   242 ERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIP---------PVITTNH 297
            ||..|.|.|..::|.::|..| .:|:|:.|||:||::.:.:|   .::|         ||
Human   656 ERSLNTDVLFGLLREVVARRS-DLKLIVTSATMDAEKFAAFF---GNVPIFHIPGRTFPV----- 711

  Fly   298 RRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEA 362
                                  |:...:.|:  :....||||              ||.|.:...
Human   712 ----------------------DILFSKTPQ--EDYVEAAVK--------------QSLQVHLSG 738

  Fly   363 LRYGAVLIFLPGIYEI----DTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFR 423
            .. |.:|||:||..:|    |.:.|:|. .|||.|  .::::..:|.:..:.|..:|...|.|.|
Human   739 AP-GDILIFMPGQEDIEVTSDQIVEHLE-ELENAP--ALAVLPIYSQLPSDLQAKIFQKAPDGVR 799

  Fly   424 KIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGR 488
            |.|:.|||||:|:||..:.:|||....|:||.:......:|::...|:||..||:||.||...|:
Human   800 KCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQ 864

  Fly   489 VYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLL 553
            .:|:..:..|:.|:....:||:.|..|.|.||..|.|.:...::.  ..:.||...::.|::..|
Human   865 CFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQF--HFMDPPPEDNMLNSMYQL 927

  Fly   554 KEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGL 618
            ..:|||..|         |.||..|.:|...|||...|:::|:........|.::|.:.||.|.:
Human   928 WILGALDNT---------GGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAI 983

  Fly   619 FAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHV---SL 680
            |....||.:..|.....:...:   ||       :|||||:.....:...:..|.....:   ::
Human   984 FYRPKGREEESDQIREKFAVPE---SD-------HLTYLNVYLQWKNNNYSTIWCNDHFIHAKAM 1038

  Fly   681 RSLKEIHLLVQELRVR 696
            |.::|:...::::.|:
Human  1039 RKVREVRAQLKDIMVQ 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	174/599 (29%)
		DEXHc_TDRD9	115..295	CDD:350746	68/188 (36%)
		TUDOR	892..1016	CDD:425754
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..320
		HrpA	532..>1146	CDD:441249	174/598 (29%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1227