DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and Dqx1

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_291084.1	Gene:	Dqx1 / 93838	MGIID:	2136388	Length:	718	Species:	Mus musculus

Alignment Length:	695	Identity:	158/695 - (22%)
Similarity:	268/695 - (38%)	Gaps:	167/695 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 YYKKFRFNLNRDKNLSIYAKREEILAAINAHP--VVIIKGETGCGKTTQVPQ----YILDEAYKS 159
            ||:.    |.:.:.|.|:|.|...|..:.:.|  ||::.|:.|.||:||:||    :.|...:::
Mouse    32 YYEL----LEQRRALPIWAARFLFLEHLESSPTGVVLVSGDPGSGKSTQIPQWCAEFALARGFQT 92

  Fly   160 GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLED-----TRLLYCTTGVL 219
            |:   :.||||..:||:|:|:||..|    .:.....::|...|.  ||     |.|.:|...:.
Mouse    93 GQ---VTVTQPYPLAAMSLASRVADE----MDLTLGHEIGYSIPQ--EDCTGPNTMLRFCWDRLF 148

  Fly   220 LNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFT 284
            |..:.:.:....::.::|||..||....|.|..::|.                           |
Mouse   149 LQEVASTRGPGAWSVLILDEAQERSVASDLLQGLLRD---------------------------T 186

  Fly   285 TTNSIP----PVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIID 345
            ...::|    .|:.|:...:...:.|         |....:  .:||.........|.|..|..|
Mouse   187 RLRNLPGDPRVVVVTDPALEPKFQAF---------WGNSPI--VRVPREPGGDPTLAYKDTVPTD 240

  Fly   346 NMER--KAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTP 408
            .:|.  :|.::..|. :||  .|.||::||...||....|:|:..:.             :|..|
Mouse   241 LVEAACQAVLELCQQ-EEA--PGDVLVYLPSEEEISLCCESLSGEMG-------------TLAVP 289

  Fly   409 ENQRDVFNPPP------PG---------------FRKIILTTNIAESSITVPDVSYVIDFCLAKV 452
                   .|||      ||               .|||::|..:|:.|.::|.:.:|||..|...
Mouse   290 -------GPPPRVLPLHPGCAQAIQTVYEDTDVSVRKIVVTHWLADFSFSLPSIQHVIDSGLELR 347

  Fly   453 KVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQN 517
            .|.:......|..|...||.....|..|......|...|:.:|...:.|.|....|::....|.:
Mouse   348 SVYNPRIRAESQVLRPISKCQAEARLLRAKGFPPGSCLRLYSKSTLELEAPPLPHPKVCEENLSS 412

  Fly   518 SVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGAL-YLTVDGIYDPLDGDLTYWGTIM 581
            .||......:..|.|...|....|.        .|::.:..| ||.  .:.|  ||:|:..|.|:
Mouse   413 LVLLLMRKQIAEPGECHFLDRPAPE--------ALMRALEDLDYLA--ALND--DGELSDLGVIL 465

  Fly   582 SRLPLDTRQSRLIILGYIFNMLEEAIIIAA------GLSTPGLFAHEGGRSQLGDSFWMHYIFSD 640
            |..||....::.::....||.::|.:.:||      |.:.|.|.|.|....:..:       .:|
Mouse   466 SEFPLPPELAKALLASCEFNCVDEMLTLAAMLTAAPGFTRPPLSAGEAALRRALE-------HAD 523

  Fly   641 GSGSDLVAIWRVYLTYLNIVENGHD----QESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLG 701
            |..|.|:.::..:      |::|.|    |...:.|.     ||...:::...:.||..|
Mouse   524 GDHSSLIQVYEAF------VQSGADEAWCQARGLNWE-----SLCQARKLRAELVELMQR----- 572

  Fly   702 LIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTD 746
             |..|::......::.:..:.|.:::|     ||.:   ...|||
Mouse   573 -IELPLSQPAFGSEQNRRDLQKALLSG-----YFLK---VARDTD 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	145/632 (23%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Dqx1	NP_291084.1	HrpA	9..672	CDD:224557	158/695 (23%)
		DEAQ box	167..170		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900