DRSC/TRiP Functional Genomics Resources

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Protein Alignment spn-E and DHX57

DIOPT Version :9

Sequence 1:NP_476741.1 Gene:spn-E / 41919 FlyBaseID:FBgn0003483 Length:1434 Species:Drosophila melanogaster
Sequence 2:NP_945314.1 Gene:DHX57 / 90957 HGNCID:20086 Length:1386 Species:Homo sapiens


Alignment Length:962 Identity:260/962 - (27%)
Similarity:424/962 - (44%) Gaps:198/962 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 VPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYY---- 102
            ||:|..|......|.|...    |..:.|:.|:.::....::.|.|| |....|..::.|.    
Human   442 VPSRTRINNPACHKTVIPN----NSFVSNQIPEVEKASESEESDEDD-GPAPVIVENESYVNLKK 501

  Fly   103 ---------------------KKFRFN---------LNRDKNLSIYAKREEILAAINAHPVVIIK 137
                                 |:||..         |...::|..:.:||.||..:..|.||:|.
Human   502 KISKRYDWQAKSVHAENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVIS 566

  Fly   138 GETGCGKTTQVPQYILDEAYKS--GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGL 200
            |.||||||||:||:|||::...  .|..||:.||||||:|||:|.||.:||..:......:|:.|
Human   567 GMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRL 631

  Fly   201 HRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHV 265
            ....| ..||||||||||||..|..:..|...:||::||||||.:..||||:|::.:::... .:
Human   632 ESVKS-SATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLLLVLKDIVSQRP-GL 694

  Fly   266 KIILMSATIDAKELSDYFTTTNSIPPVIT-------------------TNH-------------- 297
            ::||||||::|:..||||.:.    ||||                   |.:              
Human   695 QVILMSATLNAELFSDYFNSC----PVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQ 755

  Fly   298 ---------RRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEIN----------KHGYRAAVKIIVI 343
                     |.:.:.|:...|...|:...::|.....||:..          |...::.:|.:.|
Human   756 ISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSI 820

  Fly   344 ID----NMERKAA-----IQSRQSYDEALRYGAVLIFLPGIYEIDTMAENL--TCMLENDPNIKV 397
            :|    |:|...|     :..:.||..    ||:|:||||:.||..:.|.|  ..:..|..:.:.
Human   821 MDFEKVNLELIEALLEWIVDGKHSYPP----GAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRC 881

  Fly   398 SIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFS 462
            .|....|.::.|.|:.||..||.|..|||::|||||:|||:.||.||||....|.|..|.:....
Human   882 VIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGME 946

  Fly   463 SLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNM 527
            ||..|:.|:||..||.||.||:.||..:.:...|.|..::.:..:||:.|:||:...|:.|:|.|
Human   947 SLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEM 1011

  Fly   528 GSP---VEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTR 589
            .|.   ..:.:..:.||:...:..:.:.|:::||  ||.|....||       |..::.||:|.|
Human  1012 FSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGA--LTPDERLTPL-------GYHLASLPVDVR 1067

  Fly   590 QSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYL 654
            ..:|::.|.||..|:.|:.|||.|:....|.....:.:..:...:.:.|::   ||.:|:.:.|.
Human  1068 IGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFAN---SDYLALLQAYK 1129

  Fly   655 TYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQ-------- 711
            .:....:.|  ..::..:.::..:|.|.|:|:..|.::.....:.:|.....:...:        
Human  1130 GWQLSTKEG--VRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGG 1192

  Fly   712 --MMD--------DREKAIMLKVIIAGAFYPNYF----------------TRSKESCAD----TD 746
              ::|        :.|...::..::..|.|||..                .|.:...|:    |.
Human  1193 DGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTK 1257

  Fly   747 RNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIK------------ELFQEVRIPPENMDVTFQ 799
            .:.|..|  |.........:|...|:  ||..:||            .::..|......::|..|
Human  1258 NDGYVHI--HPSSVNYQVRHFDSPYL--LYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQ 1318

  Fly   800 EGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAV-----MMRQNRVERP 846
            .|.   ||....|.||    ::|..|.:| :|:.|.:     .:.|::::.|
Human  1319 RGE---FVVSLDDGWI----RFVAASHQV-AELVKELRCELDQLLQDKIKNP 1362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spn-ENP_476741.1 HrpA 113..>697 CDD:224557 206/651 (32%)
TUDOR 892..1016 CDD:395449
DHX57NP_945314.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..147
UBA_DHX57 181..218 CDD:270502
RWD 243..418 CDD:283440
ZnF_C3H1 303..323 CDD:214632
DEXDc 550..730 CDD:214692 84/185 (45%)
DEXDc 561..703 CDD:238005 69/143 (48%)
DEVH box 668..671 2/2 (100%)
Helicase_C 832..968 CDD:278689 55/139 (40%)
HA2 1043..1125 CDD:214852 27/93 (29%)
OB_NTP_bind 1164..1310 CDD:285018 20/149 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D278674at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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