Protein Alignment spn-E and PRP22

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_010929.3
• Gene: PRP22 / 856732
• SGDID: S000000815
• Length: 1145
• Species: Saccharomyces cerevisiae
• Alignment Length: 866
• Identity: 206/866 - (23%)
• Similarity: 376/866 - (43%)
• Gaps: 114/866 - (13%)

  Fly     2 DQEVMDFFDFSKELKRVAAAPQGYISSDPRLMATKFKSSEVPNRE--LIGTDYVSKIVAKEKCLL 64
            ||:|.....:  |:.::...|:|:::..    |....::...:||  |.....:.:.:.|::...
Yeast   374 DQQVKGAKKY--EMPKITKVPRGFMNRS----AINGSNAIRDHREEKLRKKREIEQQIRKQQSFD 432

  Fly    65 NGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKFRFNLNRDK-NLSIYAKREEILAAI 128
            :.| .|::.....|:.|.:.....|.|:..:.....|.|:....::..: .|.:||.|.|::.|:
Yeast   433 DPT-KNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAV 496

  Fly   129 NAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTV 193
            ..:..::|.||||.|||||:.||:.:|.:.:  |..|..|||||:||:|:|.||.:|...:....
Yeast   497 RDNQFLVIVGETGSGKTTQITQYLDEEGFSN--YGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHD 559

  Fly   194 CSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLL 258
            ..:.:....... .|||:.|.|.|:|....:.:..::.|:.|:|||.|||....|.|..:::: .
Yeast   560 VGYTIRFEDVTG-PDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKK-A 622

  Fly   259 ATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGH 323
            |.....:|:|:.|||:::.:.|:||...    |:|.. ..:...:|..|
Yeast   623 AIKRPELKVIVTSATLNSAKFSEYFLNC----PIINI-PGKTFPVEVLY---------------- 666

  Fly   324 QQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCM 388
            .|.|:::.  ..||:..::.|...|..               |.:|:||.|..|||:..|.|...
Yeast   667 SQTPQMDY--IEAALDCVIDIHINEGP---------------GDILVFLTGQEEIDSCCEILYDR 714

  Fly   389 LE--NDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAK 451
            ::  .|...::.|:..:|.:..|.|..:|.|.|.|.||::..|||||:|||:..:.||:|...||
Yeast   715 VKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAK 779

  Fly   452 VKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQ 516
            :.:.:..:....|.::..|:|...||.||.||...|:.||:..:..:..||.|..:||:.|..|.
Yeast   780 INIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLS 844

  Fly   517 NSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIM 581
            :::|..|.:.:...::...:...|.|        |:|..:..|| .:..:.|  :|.||..|..|
Yeast   845 HTILMLKAMGINDLLKFDFMDPPPKN--------LMLNALTELY-HLQSLDD--EGKLTNLGKEM 898

  Fly   582 SRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDS--FWMHYIFSDGSGS 644
            |..|:|...||.::........:|.:.|.:.||...:|.....|....||  ...|:.:.|
Yeast   899 SLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGD---- 959

  Fly   645 DLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLG--LIPFPV 707
                    :||.||:.........:.::.|...:..|.||....:..::.:....:|  ||....
Yeast   960 --------HLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHS 1016

  Fly   708 NPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNI-YQTISG------HDPCRTVYFT 765
            :|:         ::.|..::|.|.         :.|..|..: |:||:|      | |..::|..
Yeast  1017 DPD---------LIRKTFVSGFFM---------NAAKRDSQVGYKTINGGTEVGIH-PSSSLYGK 1062

  Fly   766 NFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQS 830
            .::......:.....:.:.|...|.|:    ...|.:...:.....:......:|.:|:..:...
Yeast  1063 EYEYVMYHSIVLTSREYMSQVTSIEPQ----WLLEVAPHFYKAGDAESQSRKKAKIIPLHNKFAK 1123

  Fly   831 E--VYKAVMMRQNRVERPIHI 849
            :  .::...:||:| ||.:.|
Yeast  1124 DQNSWRLSSIRQSR-ERALGI 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	159/586 (27%)
		DEXHc_TDRD9	115..295	CDD:350746	61/179 (34%)
		TUDOR	892..1016	CDD:425754
PRP22	NP_010929.3	GH2_like	<12..58	CDD:425380
		GH2_like	75..136	CDD:409667
		S1_DHX8_helicase	178..257	CDD:240189
		HrpA	483..>1097	CDD:441249	179/701 (26%)