DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and PRP22

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	866	Identity:	206/866 - (23%)
Similarity:	376/866 - (43%)	Gaps:	114/866 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DQEVMDFFDFSKELKRVAAAPQGYISSDPRLMATKFKSSEVPNRE--LIGTDYVSKIVAKEKCLL 64
            ||:|.....:  |:.::...|:|:::..    |....::...:||  |.....:.:.:.|::...
Yeast   374 DQQVKGAKKY--EMPKITKVPRGFMNRS----AINGSNAIRDHREEKLRKKREIEQQIRKQQSFD 432

  Fly    65 NGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKFRFNLNRDK-NLSIYAKREEILAAI 128
            :.| .|::.....|:.|.:.....|.|:..:.....|.|:....::..: .|.:||.|.|::.|:
Yeast   433 DPT-KNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAV 496

  Fly   129 NAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTV 193
            ..:..::|.||||.|||||:.||:.:|.:.:  |..|..|||||:||:|:|.||.:|...:....
Yeast   497 RDNQFLVIVGETGSGKTTQITQYLDEEGFSN--YGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHD 559

  Fly   194 CSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLL 258
            ..:.:....... .|||:.|.|.|:|....:.:..::.|:.|:|||.|||....|.|..:::: .
Yeast   560 VGYTIRFEDVTG-PDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKK-A 622

  Fly   259 ATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGH 323
            |.....:|:|:.|||:::.:.|:||...    |:|.. ..:...:|..|
Yeast   623 AIKRPELKVIVTSATLNSAKFSEYFLNC----PIINI-PGKTFPVEVLY---------------- 666

  Fly   324 QQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCM 388
            .|.|:::.  ..||:..::.|...|..               |.:|:||.|..|||:..|.|...
Yeast   667 SQTPQMDY--IEAALDCVIDIHINEGP---------------GDILVFLTGQEEIDSCCEILYDR 714

  Fly   389 LE--NDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAK 451
            ::  .|...::.|:..:|.:..|.|..:|.|.|.|.||::..|||||:|||:..:.||:|...||
Yeast   715 VKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAK 779

  Fly   452 VKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQ 516
            :.:.:..:....|.::..|:|...||.||.||...|:.||:..:..:..||.|..:||:.|..|.
Yeast   780 INIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLS 844

  Fly   517 NSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIM 581
            :::|..|.:.:...::...:...|.|        |:|..:..|| .:..:.|  :|.||..|..|
Yeast   845 HTILMLKAMGINDLLKFDFMDPPPKN--------LMLNALTELY-HLQSLDD--EGKLTNLGKEM 898

  Fly   582 SRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDS--FWMHYIFSDGSGS 644
            |..|:|...||.::........:|.:.|.:.||...:|.....|....||  ...|:.:.|
Yeast   899 SLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGD---- 959

  Fly   645 DLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLG--LIPFPV 707
                    :||.||:.........:.::.|...:..|.||....:..::.:....:|  ||....
Yeast   960 --------HLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHS 1016

  Fly   708 NPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNI-YQTISG------HDPCRTVYFT 765
            :|:         ::.|..::|.|.         :.|..|..: |:||:|      | |..::|..
Yeast  1017 DPD---------LIRKTFVSGFFM---------NAAKRDSQVGYKTINGGTEVGIH-PSSSLYGK 1062

  Fly   766 NFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQS 830
            .::......:.....:.:.|...|.|:    ...|.:...:.....:......:|.:|:..:...
Yeast  1063 EYEYVMYHSIVLTSREYMSQVTSIEPQ----WLLEVAPHFYKAGDAESQSRKKAKIIPLHNKFAK 1123

  Fly   831 E--VYKAVMMRQNRVERPIHI 849
            :  .::...:||:| ||.:.|
Yeast  1124 DQNSWRLSSIRQSR-ERALGI 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	159/588 (27%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
PRP22	NP_010929.3	Pnp	1..423	CDD:224106	10/54 (19%)
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	191/777 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810