DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and PRP2

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_014408.1	Gene:	PRP2 / 855745	SGDID:	S000005294	Length:	876	Species:	Saccharomyces cerevisiae

Alignment Length:	808	Identity:	203/808 - (25%)
Similarity:	340/808 - (42%)	Gaps:	177/808 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DYVSK---IVAKEKCLLNGTLLNE-QPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKFRFNLNR 111
            ||.::   ::.:||......|... :.:.|||.|:.           |.|
Yeast   182 DYTNEEDDLLPEEKLQYEARLAQALETEEKRILTIQ-----------EAR--------------- 220

  Fly   112 DKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAI 176
             |.|.::..::|:|..|..:.|:||.||||.|||||:|||::::.:.......|.:|||||:||.
Yeast   221 -KLLPVHQYKDELLQEIKKNQVLIIMGETGSGKTTQLPQYLVEDGFTDQGKLQIAITQPRRVAAT 284

  Fly   177 SIANRVCQEREWQQNTVCSFQVGLH-------RPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTH 234
            |:|.||..|    .|.|...:||..       .||.   |.|.|.|.|:||...:.:..|:.|:.
Yeast   285 SVAARVADE----MNVVLGKEVGYQIRFEDKTTPNK---TVLKYMTDGMLLREFLTDSKLSKYSC 342

  Fly   235 IVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRR 299
            |::||.|||....|.|:.:::.:|..... :|:::.|||::||:.|::|...    |:.....||
Yeast   343 IMIDEAHERTLATDILIGLLKDILPQRPT-LKLLISSATMNAKKFSEFFDNC----PIFNVPGRR 402

  Fly   300 KHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALR 364
             :.::..|..|                ||.|.  ..||:..|.         .|.:.||..
Yeast   403 -YPVDIHYTLQ----------------PEANY--IHAAITTIF---------QIHTTQSLP---- 435

  Fly   365 YGAVLIFLPGIYEID---TMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKII 426
             |.:|:||.|..||:   |..|.:...|.:... ::.|...::.:..|.|..:|.|.|...||::
Yeast   436 -GDILVFLTGQEEIERTKTKLEEIMSKLGSRTK-QMIITPIYANLPQEQQLKIFQPTPENCRKVV 498

  Fly   427 LTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYR 491
            |.|||||:|:|:..:.||||....|......::..:.|.....|:|:..|||||.||:..|:.:|
Yeast   499 LATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRAGRVGPGKCFR 563

  Fly   492 MVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEV 556
            :..|..|..|:.....||:.|..|.|:||  .:|::|....|....:..|::..:..::..|..:
Yeast   564 IFTKWSYLHELELMPKPEITRTNLSNTVL--LLLSLGVTDLIKFPLMDKPSIPTLRKSLENLYIL 626

  Fly   557 GALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIF----NMLEEAIIIAAGL-STP 616
            |||         ...|.:|..|.:|...|.:...::::......    .:|||.:.|.:.| .||
Yeast   627 GAL---------NSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSMLHETP 682

  Fly   617 GLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLR 681
            .||        :|..       .|.:.|.|..:...::.||.|.....:.:.:..|.:...:..:
Yeast   683 SLF--------IGQK-------RDAAASVLSEVESDHILYLEIFNQWRNSKFSRSWCQDHKIQFK 732

  Fly   682 SLKEIHLLVQELRVRCTH-LGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESC--A 743
            ::..:..:..:| .||:. :||:          :..::|.|....|||     |.......|  :
Yeast   733 TMLRVRNIRNQL-FRCSEKVGLV----------EKNDQARMKIGNIAG-----YINARITRCFIS 781

  Fly   744 DTDRNI-------YQT---------ISGHDPCRTVYFTNFKPAYMGELYTRRIK-ELFQEVRIPP 791
            ....||       |||         :|.|.  .::.|.|.|     |...|..| .|:|::.:
Yeast   782 GFPMNIVQLGPTGYQTMGRSSGGLNVSVHP--TSILFVNHK-----EKAQRPSKYVLYQQLML-- 837

  Fly   792 ENMDVTFQEGSQKVFV----TFKQDDWI 815
                      :.|.|:    ...:::|:
Yeast   838 ----------TSKEFIRDCLVIPKEEWL 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	163/598 (27%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
PRP2	NP_014408.1	PTZ00121	<7..174	CDD:173412
PRP2	NP_014408.1	HrpA	185..876	CDD:224557	201/805 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810