Protein Alignment spn-E and ECM16

DIOPT Version :9

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_013847.1
• Gene: ECM16 / 855158
• SGDID: S000004735
• Length: 1267
• Species: Saccharomyces cerevisiae
• Alignment Length: 1175
• Identity: 257/1175 - (21%)
• Similarity: 450/1175 - (38%)
• Gaps: 397/1175 - (33%)

  Fly     2 DQEVMDFFDFSKE-LKRVAAAPQ--GYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCL 63
            |||..|....|:. |:.|.:|..  |....|...:|.:||  :..|:|      :.|:..:::.|
Yeast   280 DQEEEDKMHPSENPLEEVESADSETGSEKFDQNDVANEFK--DWANQE------IKKLEGRDQEL 336

  Fly    64 LNGTL-LNEQPQGKRIRTLDDLDTDDEGEE---------------TEIRRDDEYYKKFRFNLNRD 112
            :..|| ::.:|    |...:||  ||..:|               .|:.|.|| .:|.|.
Yeast   337 VTPTLNIDYKP----IIRKEDL--DDGLQEAYVPINENSTRKAFYVEVSRSDE-IQKARI----- 389

  Fly   113 KNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAY---KSGKYCNIV-VTQPRRI 173
             .|.::.:..:|:.||:.:.||||.||||.||||||||::.:..:   .|..|..:| :|||||:
Yeast   390 -QLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQPRRV 453

  Fly   174 AAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLD 238
            ||:|:|.||..|.....:.| .:|:... ..:.|||::.:.|.||||..::::..||.|:.|::|
Yeast   454 AAVSMAERVANELGDHGHKV-GYQIRFD-STAKEDTKVKFMTDGVLLREMMHDFKLTKYSSIIID 516

  Fly   239 EVHERDQNMDFLLIVVRRLLATNS----------RHVKIILMSATIDAKELSDYFTTTNSIPPVI 293
            |.|||:.|.|.|:.::.|.:...:          :.:|:|:||||:...:.|:..|.....|||:
Yeast   517 EAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENKTLFPIAPPVL 581

  Fly   294 TTNHR---------RKHSIEKFYRDQL-------------GSI---IWNEEDVGH------QQVP 327
            ..:.|         |:.:..  |.|:.             |:|   :..::::.|      ::.|
Yeast   582 QVDARQFPVSIHFNRRTAFN--YTDEAFRKTCKIHQKLPPGAILVFLTGQQEITHMVKRLRKEFP 644

  Fly   328 -------------EINKHGYRAAVK---------IIVIIDNMERKAAI----------------- 353
                         .::|.|..:...         .:.:||..:.|:||
Yeast   645 FKKNSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRYEEDEGNSGNGEDEED 709

  Fly   354 QSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPP 418
            :..:.::|.|..|                     ...|||   :.::..:||:..:.|..||..|
Yeast   710 EEEEGFEEVLTEG---------------------QTANDP---LYVLPLYSLLPTKEQMRVFQKP 750

  Fly   419 PPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGR 483
            |.|.|..|:.||:||:|:|:|.|.||:|...:|.:..:.::...|..:.|.|||:..||:||.||
Yeast   751 PQGSRLCIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGR 815

  Fly   484 LRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAK------VLNMGSPVEILALALSPPN 542
            ...|..||:.:...::.:..:|..||:||:|:::.||:.|      ::|...|        :||:
Yeast   816 TGPGHCYRLYSSAVFEHDFEQFSKPEILRMPVESIVLQMKSMAIHNIINFPFP--------TPPD 872

  Fly   543 LSDIHNTILLLKEVGAL----YLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNML 603
            ...:...|.||:.:|||    .:|.|             |..||..||..|.|:::::......|
Yeast   873 RVALSKAIQLLQYLGALDNKEMITED-------------GKKMSLFPLSPRFSKMLLVSDEKACL 924

  Fly   604 EEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQES 668
            ...:.|.:.||             :||.|
Yeast   925 PYIVAIVSALS-------------VGDPF------------------------------------ 940

  Fly   669 AIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPN 733
                          :.|..|.:.|:..:          .||::.:||:
Yeast   941 --------------INEFELGINEISRK----------PNPDENLDDK----------------- 964

  Fly   734 YFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTF 798
                        .|...::..|.||               || .:.::..|.:.|.....:| .|
Yeast   965 ------------IREHDESTPGMDP---------------EL-KKELRSKFYKSRSQFSKLD-KF 1000

  Fly   799 QEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQRG 863
            .:..:.:.|....|        |||   :.|.|::    |::|
Yeast  1001 SDVFRLLSVVSAMD--------YVP---KEQKEIF----MKKN---------------------- 1028

  Fly   864 IGDVIEGRWIPPTKPLNVELLALPSVFDKTISGSITCIVNCGKFFFQPQSFEECIRNMSEIFNAP 928
               .:.|:.:.....|..:|:.:  :...|...:|..:                |||
Yeast  1029 ---FLRGKLMEEIVKLRKQLMYI--IKSNTSKENIAVV----------------IRN-------- 1064

  Fly   929 QQLRNYVTNASAI--AKGMMVLAKRDSYFQRATVIRPENQ--SNRQ--------PMFYVRFIDYG 981
            :.|::.:.:...|  .|.|:.....|....||.|:.|::.  :||.        |:...|..:..
Yeast  1065 EDLKSDIPSVIQIKLLKQMICAGFVDHVAVRADVLFPDDAKITNRTSIINIPYIPVLATRTPNIE 1129

  Fly   982 NCTLLPMQLMRLMPRELTEQYGDLPPRVFECRLAMVQPSSVVSGNN--RWST---AANDMLKTVA 1041
            :|      .:.:.|..:....|::||:.      |:..|..:.|||  |.:|   .|:..|..:|
Yeast  1130 DC------FVYIHPTSILNNLGEMPPKY------MLYYSLHLGGNNKTRMNTLCDIASTPLANIA 1182

  Fly  1042 QCGLI 1046
            :.||:
Yeast  1183 RKGLL 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	164/677 (24%)
		TUDOR	892..1016	CDD:395449	23/135 (17%)
ECM16	NP_013847.1	HrpA	360..1267	CDD:224557	232/1081 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810