DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and PRP16

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_013012.3	Gene:	PRP16 / 853961	SGDID:	S000001794	Length:	1071	Species:	Saccharomyces cerevisiae

Alignment Length:	660	Identity:	185/660 - (28%)
Similarity:	298/660 - (45%)	Gaps:	99/660 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SKIVAKEKCLL--------NGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKFRFNLN 110
            ||:||..:..:        |.|:|| ...|: :..|::.:...:....:|..|...:...:.::.
Yeast   282 SKLVALRRINMEHIQQSRDNTTVLN-TAMGE-VLGLENNNKAKDKSNQKICDDTALFTPSKDDIK 344

  Fly   111 RDK-NLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIA 174
            ..| .|.::..|.::|:.|..:.||:|.||||.|||||:.||:.:|.|.:.:..:||||||||:|
Yeast   345 HTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVA 409

  Fly   175 AISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDE 239
            |||:|.||..|.:........:.:........|.|:|.:.|.|:||...:.:.||..|:.:::||
Yeast   410 AISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDE 474

  Fly   240 VHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTN--SIPPVITTNHRRKHS 302
            .|||..|.|.||...:.||| ..|.:|:|:.|||::||:.|.:|....  :||       .|...
Yeast   475 AHERSLNTDILLGFFKILLA-RRRDLKLIITSATMNAKKFSAFFGNAPQFTIP-------GRTFP 531

  Fly   303 IEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGA 367
            ::..|..              ..|.:..:.....||||.:..|                 ...|.
Yeast   532 VQTIYTS--------------NPVQDYVEAAVSQAVKIHLAND-----------------CSSGD 565

  Fly   368 VLIFLPGIYEIDTMAENL-------------TCMLE--NDPNIKVSIVRCFSLMTPENQRDVFNP 417
            :|||:.|..:|:|..:.|             |...|  ||    :.|:..:|.:..:.|..:|..
Yeast   566 ILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEIND----IEILPIYSALPADLQFKIFQD 626

  Fly   418 PPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVG 482
            .....||||:.|||||:|:|:..:.||||...:|:||.:......||.:|..||||..||:||.|
Yeast   627 LHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAG 691

  Fly   483 RLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIH 547
            |...|..||:..:..::.:|....|||:.|..|.|::|..|.|::...:........|| |....
Yeast   692 RTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPP-LQTFL 755

  Fly   548 NTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAG 612
            :::..|..:||:         ...|.||..|..|::.||....|:::::.......:|.:.|.:.
Yeast   756 SSLYELWFIGAI---------DTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSM 811

  Fly   613 LSTPGLFAHEGGRSQLGD----SFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWA 673
            ||.|.:|.....|.:..|    .|::       :.||       :||.||:.|.......:..|.
Yeast   812 LSVPQVFYRPKERQKEADIARNKFFI-------AKSD-------HLTLLNVFEQWRANNFSSHWC 862

  Fly   674 KRFHVSLRSL 683
            .:..|..:||
Yeast   863 NKHFVQYKSL 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	173/593 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
PRP16	NP_013012.3	HrpA	319..1071	CDD:224557	175/621 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810