Protein Alignment spn-E and DHR2

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_012845.1
• Gene: DHR2 / 853784
• SGDID: S000001561
• Length: 735
• Species: Saccharomyces cerevisiae
• Alignment Length: 805
• Identity: 205/805 - (25%)
• Similarity: 348/805 - (43%)
• Gaps: 159/805 - (19%)

  Fly    48 IGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDE----YYKKFRFN 108
            :.:::.||   |:|...|........:.||...:...:...||:....:|.::    .||..:..
Yeast     9 VASNHTSK---KQKVRRNIHPFTNNTRIKRASKIVKFNDSGEGDHVSDQRSNKENVLTYKSLKSR 70

  Fly   109 ----LNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQ 169
                |...:.|.:|..:.||::.|.::||.::.||||.||:||:||::|::.|.:.|:.:|.|||
Yeast    71 ASDLLKMRETLPVYQHKREIMSYIESNPVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQ 135

  Fly   170 PRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTH 234
            |||:|||::|.||.||...:......:.|......:.. |||.|.|.|:||..|:.|..|..|:.
Yeast   136 PRRVAAINLATRVAQEHGCKLGEQVGYSVRFDNTTTTR-TRLKYLTDGMLLRELMMNSDLREYSV 199

  Fly   235 IVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRR 299
            ||:||.|||....|.:|..::.|:......::||:||||:.|::.|::|   |:.|.:....  |
Yeast   200 IVIDEAHERTVLTDLILGFLKSLIQGPRPDLRIIVMSATLQAEKFSEFF---NNAPILFVEG--R 259

  Fly   300 KHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALR 364
            |..::::|                .:.|..:            |:|.:.| ..||..|..:
Yeast   260 KFDVKQYY----------------LKAPTDD------------IVDAVIR-CCIQINQGEE---- 291

  Fly   365 YGAVLIFLPGIYEID---TMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGF-RKI 425
            .|.:|.||||..|||   |:.|.:...:.::..:.:.:........|..|:.:...|..|| ||:
Yeast   292 LGDILCFLPGQEEIDKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKGFKRKV 356

  Fly   426 ILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVY 490
            :.:|||||:|:|:..|.:|:|..|.||||.......::|.....|:|:..||:||.||...|:.:
Yeast   357 VFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRESEGKSF 421

  Fly   491 RMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKE 555
            |:..:..|.: :|:...||:.|                               ||:.:.:|:||.
Yeast   422 RLYCESDYVK-LPKQSEPEIAR-------------------------------SDVTSPVLMLKR 454

  Fly   556 VG----------------ALYLTVDGIYD--PLD--GDLTYWGTIMSRLPLDTRQSRLIILGYIF 600
            .|                |:.:.:..:|:  .||  |.:|..|..|:.|||....|.::|.....
Yeast   455 YGVDDLLNWTWFENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLIKASEV 519

  Fly   601 NMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSG---SDLVAIWRVYLTYLNIVEN 662
            ..|.:.|.|.:.||...|..:.....:  |......:....:|   .||:.:..::..|  ..|.
Yeast   520 GCLSQVIDIVSCLSVENLLLNPSPEER--DEVNERRLSLCNAGKRYGDLIMLKELFDIY--FYEL 580

  Fly   663 GHDQESAIR---WAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKAI---- 720
            |..|:::..   |.|...:|:|..|.:..:..:|||.|..|      .:.....|:..|.|
Yeast   581 GKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRL------FSSISEEDEESKKIGEDG 639

  Fly   721 -----MLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISGHDP--------------CRTVYFTN 766
                 :||..:.| |..|      .:....||: |:|:|..:|              |..:.:|.
Yeast   640 ELISKILKCFLTG-FIKN------TAIGMPDRS-YRTVSTGEPISIHPSSMLFMNKSCPGIMYTE 696

  Fly   767 FKPAYMGELYTRRIKEL----FQEV 787
            :  .:..:.|.|.:..:    .|||
Yeast   697 Y--VFTTKGYARNVSRIELSWLQEV 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	169/612 (28%)
		DEXHc_TDRD9	115..295	CDD:350746	69/179 (39%)
		TUDOR	892..1016	CDD:425754
DHR2	NP_012845.1	HrpA	79..>534	CDD:441249	151/525 (29%)
		OB_NTP_bind	645..722	CDD:400182	18/85 (21%)