DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and YLR419W

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_013523.3	Gene:	YLR419W / 851137	SGDID:	S000004411	Length:	1435	Species:	Saccharomyces cerevisiae

Alignment Length:	981	Identity:	254/981 - (25%)
Similarity:	425/981 - (43%)	Gaps:	201/981 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QGYISSDPRLMATKF-KSSEVPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRI-------- 78
            :.|.:|.|.::.:.| |:.::|       ||:.|.:...       ||:...:|..|
Yeast   470 KNYPASLPGIVVSTFDKNYKLP-------DYIKKQILTR-------LLHYLQEGNLIGDMLVYHI 520

  Fly    79 ---------RTLDD-----LDTDDEG----------------------EETEIRRD------DEY 101
                     :.:|:     .|:|.:|                      .:|.|..|      :||
Yeast   521 YEWLKENISKIIDNPGPLIPDSDSKGAINKRNISNGKRSINNSSSRKFTKTTISEDTLSVLREEY 585

  Fly   102 YKKFR------FNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS- 159
            .|:.:      ..|.|:: |..:.|::.|:..||.:.||:|.||||.||:|||.|:|||...|.
Yeast   586 TKRIKSSEYKSMQLVREQ-LPAWKKQKVIIDIINKNEVVLITGETGSGKSTQVVQFILDFLQKEK 649

  Fly   160 ---GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVG--LHRPNSLE-DTRLLYCTTGV 218
               || ..||.||||||:||.:|.||..||    ...|..:||  :...|..: .||:.:.||||
Yeast   650 GDFGK-TKIVCTQPRRISAIGLAERVSDER----CVTCGEEVGYVIRGVNKTKASTRIKFMTTGV 709

  Fly   219 LLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYF 283
            |:..|.|.:|:...|.:|:||||||..:.|.::.:::.|| ...|.:||:|||||::......:|
Yeast   710 LVRLLQNARTMLENTIVVIDEVHERSIDTDLIVTLMKNLL-HRVRGMKIVLMSATVNVDLFKKFF 773

  Fly   284 TTTNSIPPVITTNH---RRKHSIEKFYRDQLGSI---IWNEEDVGH--QQVPEINKHGYRAAVKI 340
                   |.:.|.|   |.....:.|..|.|..:   |..|:.:.:  ..|.|.|.
Yeast   774 -------PGLATCHIEGRTFPITDYFLEDILSDLDFKIKREKALSYDDDSVDERNN--------- 822

  Fly   341 IVIIDNMERKAAIQSR------QSYD---EALRY-----------GAVLIFLPGIYEIDTMAENL 385
                |:...|....|:      .:||   :.:.|           |::::||||:.||:... ||
Yeast   823 ----DDQYLKPRADSKFFTSGQINYDLLCQVVEYVHKRLKAANDNGSIIVFLPGVGEINKCC-NL 882

  Fly   386 TCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLA 450
            .....|:.:..|  :...|.:|||:|:.||. ...|.||::::|||||:|||:.|....||...|
Yeast   883 LANKSNEADFMV--LPLHSALTPEDQKRVFK-KYHGKRKVVVSTNIAETSITIDDCVATIDTGRA 944

  Fly   451 KVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPL 515
            |....:...:.:.|..::.|||..:||.||.||:|.|..|::.:|:.|:.:|....|||:.|:||
Yeast   945 KSMFYNPKDNTTKLIESFISKAEVKQRRGRAGRVREGLSYKLFSKNLYENDMISMPIPEIKRIPL 1009

  Fly   516 QNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTI 580
            ::..|..|.:.:......|:.||..|.|..:.....:        ||..|:.|..|..||..|..
Yeast  1010 ESLYLSVKAMGIKDVKAFLSTALDAPPLPALQKAERI--------LTTIGLVDESDKSLTQLGQF 1066

  Fly   581 MSRLP-LDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGG---RSQLGDSFWMHYIFSDG 641
            :|.:| :|::..:|:|.|.:|...:.::::.:.|.. |:....||   |.::     ...:....
Yeast  1067 ISLMPVMDSKHGKLLIYGILFGCTDISVLLVSILGI-GVLPFIGGFENREKI-----KKLLCKYE 1125

  Fly   642 SGSDLVAIWRVYLTYLNIVENGHDQESAI--RWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIP 704
            |..||.|:..:...|..|      ::|:|  ::.:...:|...:.||.....:.......:|.:|
Yeast  1126 SRGDLFAVLEIVRDYFKI------KDSSIKRKYLRDNLLSYNKINEIKSSTAQYYSILKDVGFLP 1184

  Fly   705 FPVNPNQMMD---DREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISG---HDP-CRTV 762
            .......:.|   :.....:|:.|:.||||| :..|.:.    .|.....|.||   .|| .:.:
Yeast  1185 MDYKVGSISDLNRNERNFDILRAILTGAFYP-HIARVQL----PDVKYLSTSSGAVEKDPEAKMI 1244

  Fly   763 YFTNFKPAYMGEL--YTRRIKELFQEVRIPPENMDVT--FQEGSQKVFVTFKQDDWIEGSSKYVP 823
            .:......|..:|  |..:|.:..|:|.:....:..|  |...|..:|.|...:  :|.:.....
Yeast  1245 KYWIRSEEYQDKLEEYKTKISQETQKVDLEDLPLPATRAFIHPSSVLFSTNSVN--LEDAKLLSE 1307

  Fly   824 VSGRV--QSEV-----YKAVMMRQNRVERPIHI--MNPSAFMSYVQQRG-----IGDVIEG---- 870
            |.|.:  ||::     |..|:...::|...:::  :.|:..:|.:...|     ||..|..
Yeast  1308 VDGPISRQSKIPTVVKYPFVLFTTSQVTNKLYLRDLTPTTTLSLLLFGGAISYDIGGTIHSPGIV 1372

  Fly   871 --RWIP 874
              .|:|
Yeast  1373 VDNWLP 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	185/624 (30%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
YLR419W	NP_013523.3	UBA_YLR419W_like	369..409	CDD:270457
		RWD	426..528	CDD:399058	13/71 (18%)
		HrpA	563..1428	CDD:224557	237/874 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810