Protein Alignment spn-E and DHX16

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_003578.2
• Gene: DHX16 / 8449
• HGNCID: 2739
• Length: 1041
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 199/710 - (28%)
• Similarity: 328/710 - (46%)
• Gaps: 121/710 - (17%)

  Fly    70 NEQPQGKRIRTLDDLDTDDEGEETEIRRDDE---------YYKKFRFNLNRDKNLSIYAKREEIL 125
            :::|:.:.:  |::.:|.:....|:::.|:|         ..:|......| ::|.::..|||:|
Human   348 SQEPKYQLV--LEEEETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVR-RSLPVFPFREELL 409

  Fly   126 AAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQ 190
            |||..|.|:||:||||.|||||:|||:.:|.| :.|...|..|||||:||:|:|.||.:|...:.
Human   410 AAIANHQVLIIEGETGSGKTTQIPQYLFEEGY-TNKGMKIACTQPRRVAAMSVAARVAREMGVKL 473

  Fly   191 NTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVR 255
            .....:.:......| |.|.|.|.|.|:||...::...|..|:.:::||.|||..:.|.|..:::
Human   474 GNEVGYSIRFEDCTS-ERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIK 537

  Fly   256 RLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEED 320
            . :|.....:|:::.|||:|....|.:|...    ||.....|| ..::.||
Human   538 D-VARFRPELKVLVASATMDTARFSTFFDDA----PVFRIPGRR-FPVDIFY------------- 583

  Fly   321 VGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENL 385
               .:.||.:   |..|..:.|:..::.:..              |.:|:||.|..||:...|.|
Human   584 ---TKAPEAD---YLEACVVSVLQIHVTQPP--------------GDILVFLTGQEEIEAACEML 628

  Fly   386 --TCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVID-- 446
              .|........::.::..::.:..:.|..:|.|.|||.||:::.|||||:|:|:..:.||:|
Human   629 QDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPG 693

  Fly   447 FCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEML 511
            ||  |.|..:..:...||.:|..|||:..|||||.||:.:|:.:|:.....||.|:.|..:||:.
Human   694 FC--KQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQ 756

  Fly   512 RLPLQNSVLKAKVLNMGS----------PVEILALALSPPNLSDIHNTILLLKEVGAL-YLTVDG 565
            |..|.|.||..|.|.:..          |.|.|.|||..            |..:||| :|
Human   757 RTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQ------------LYALGALNHL---- 805

  Fly   566 IYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLS-TPGLFAHEGGRSQLG 629
                  |:||..|..|:.||:|...|::|:....::..||.:.:||.|| ...:|.....:....
Human   806 ------GELTTSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHA 864

  Fly   630 DSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELR 694
            |:..:::..   .|.|.:.:..||..:   .|:|:..:    |.....|..||::....:.::|.
Human   865 DNARVNFFL---PGGDHLVLLNVYTQW---AESGYSSQ----WCYENFVQFRSMRRARDVREQLE 919

  Fly   695 VRCTHLGLIP-FPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTI 753
                  ||:. ..|..:....|..:  :.|.|.||.||         ..|...|:.|:|:
Human   920 ------GLLERVEVGLSSCQGDYIR--VRKAITAGYFY---------HTARLTRSGYRTV 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	177/598 (30%)
		DEXHc_TDRD9	115..295	CDD:350746	68/179 (38%)
		TUDOR	892..1016	CDD:425754
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..207
		PTZ00121	<148..376	CDD:173412	5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..391		3/19 (16%)
		HrpA	398..>1025	CDD:441249	191/657 (29%)
		DEAH box	520..523		2/2 (100%)