DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and dhx30

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_012820430.2	Gene:	dhx30 / 779538	XenbaseID:	XB-GENE-5777932	Length:	1184	Species:	Xenopus tropicalis

Alignment Length:	742	Identity:	220/742 - (29%)
Similarity:	350/742 - (47%)	Gaps:	134/742 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EQPQGKR-------IRTLDD------LDTDDEGEETE--IRRDDEYY----------------KK 104
            :|.|.||       ::.::|      |:.....::||  :..|.||.                :|
Frog   329 QQRQAKRFHVPEPVLQRIEDYLYQYPLEPPYPSDQTEAYVEADMEYAPDMEEASGSINDAITGRK 393

  Fly   105 FR-FNLNRDKNLS---------------------IYAKREEILAAINAHPVVIIKGETGCGKTTQ 147
            || .:|...:.:|                     :..:||.|::||..||||:|.|:|||||||:
Frog   394 FRPLSLQETERISCSLRDLWRSRQQQEVALMSLPVDGQRESIVSAIERHPVVVIAGDTGCGKTTR 458

  Fly   148 VPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTR 210
            :||:||::|...|:  .||:::||||||:|:|:|:||..|..........:||.|..........
Frog   459 IPQFILEDAILRGQGADCNMLITQPRRISAVSVAHRVGHELGPTLRRNVGYQVRLESMLPPRGGA 523

  Fly   211 LLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATID 275
            ||:||.||||..|..|.||...:||::|||||||.|.|||||:::.:...|.: :|::|||||.|
Frog   524 LLFCTVGVLLKKLQGNPTLEGVSHILVDEVHERDVNTDFLLILLKMVQQQNPK-LKVVLMSATGD 587

  Fly   276 AKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDV-----GHQQVPEINKHGYR 335
            .:.:|.||...    |:|.. ....:.:::.|.:.:.:::....|.     ..:.||:::    .
Frog   588 NERISRYFGGC----PIIRV-PGFMYPVKEHYLEDVAAMLGTSADQLTPADMEECVPDLD----L 643

  Fly   336 AAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVS-- 398
            .:..|:.|.||...                |.:|.||||..||..:.:.|.   |.....|.:
Frog   644 ISSAILHIADNGPP----------------GGILCFLPGWQEIRGVQQRLE---EKQQWAKENFL 689

  Fly   399 IVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSS 463
            |:...|.:...:|:.:|..||.|.|||:|.|||||:|:|:.|:.:|:|..:.|.:..|..:..|.
Frog   690 ILPVHSNIPMMDQQSIFQRPPQGVRKIVLATNIAETSVTIDDIVHVVDSGMQKEQRYDLRTKVSC 754

  Fly   464 LRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQRE----MPEFGIPEMLRLPLQNSVLKAKV 524
            |..:|.||:|..||.||.||.:.|..|     |.:.||    |..|.:||:||.||:|.||:|||
Frog   755 LETSWVSKSNVTQRRGRAGRCQPGFSY-----HLFTREQHKAMATFQVPEILRTPLENLVLQAKV 814

  Fly   525 -LNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDT 588
             :...:.||.|:.||..|....|.:.:.||:|:..|         ..:..||..|..:|.:..|.
Frog   815 HVPEMTAVEFLSQALESPESQAITDAVQLLQEIRVL---------DSEEQLTLLGHRVSNISTDP 870

  Fly   589 RQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGG---RSQLGDSFWMHYIFSDGSGSDLVAIW 650
            :.::.|:|..||..|...::|.|.|:..   ..:||   |:|:..:   ....|..:.||.:|..
Frog   871 KLAKAIVLASIFRCLHPMLVIVACLTRD---PFQGGLQNRAQVNRA---KKALSAETRSDHLAYV 929

  Fly   651 RVYLTYLNIV--ENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVN----- 708
            |....:..::  .||..:|:   :.:.:.:|..:|:.|..||.:.........|:.....
Frog   930 RALQGWEEVLSRRNGTAREN---FLETYSLSPGALRFIQGLVTQFSSNVYDAFLVSEASECRDGY 991

  Fly   709 --PNQMMDDREKAIMLKVIIAGAFYPN 733
              .||...:.|   :||.::....|||
Frog   992 SLCNQFSHEEE---LLKAVLLAGLYPN 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	196/623 (31%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx30	XP_012820430.2	HrpA	425..1061	CDD:224557	204/646 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010