Protein Alignment spn-E and ythdc2

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: XP_004910524.1
• Gene: ythdc2 / 779469
• XenbaseID: XB-GENE-5881731
• Length: 1457
• Species: Xenopus tropicalis
• Alignment Length: 1310
• Identity: 306/1310 - (23%)
• Similarity: 485/1310 - (37%)
• Gaps: 414/1310 - (31%)

  Fly     2 DQEVMDFFDFSKELKRV----AAAPQGYISSDPRLMATKFKSSEVPNRELI-----GTDYVSKIV 57
            ||:.|:|.......:|.    .|...|.:|.      :|.|.   |||.|.     |::..|.::
 Frog    90 DQKEMEFPSSLTSTERAFIHRLAQSLGLVSK------SKGKG---PNRCLTLKKKNGSEASSSLM 145

  Fly    58 A------KEKCLLNGTLLNEQPQGKRIRT--LDDLDTDD----EGEETEI--------------- 95
            :      .:|.:.|  |:...|...:.||  |...:..:    |.|..||
 Frog   146 SCTLTQNTKKAVCN--LIQRFPLTNKERTELLPKTERGNVYAIEAENREIGKTSGCLNGGIPQVP 208

  Fly    96 -RRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS 159
             :|.:..|..||      ::|.::.|:|:|:..|..:.||:|.||||.|||||:||:|||...|:
 Frog   209 DKRGESKYDFFR------QSLPVFEKQEDIIRIIKNNKVVLIVGETGSGKTTQIPQFILDNCQKN 267

  Fly   160 GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLI 224
            |..|.|..|||||:||||:|.||..||.........:|:.|....| ..|.|.:||.||||..|:
 Frog   268 GLPCRIFCTQPRRLAAISVAERVAAERGEIIGQCVGYQIRLESRVS-PKTLLTFCTNGVLLRTLM 331

  Fly   225 -NNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNS 288
             .:.||:..|||::|||||||:..||||..:|..:..:.. :|:||.||.:|......||...
 Frog   332 GGDSTLSAITHIIVDEVHERDRFSDFLLTKLRDAIQEHPT-LKLILSSAALDVNLFIRYFGGC-- 393

  Fly   289 IPPVITTNHRRKHSIEKFYRDQL--------GSIIWNEE-------------------------- 319
              |||....|.....|.|..|.|        |.:.:|:|
 Frog   394 --PVIYIQGRPFEVKEMFLEDILRSTGYRNKGMLKYNKEKQCEEKQKTTLTEWYSAKQKNMKPET 456

  Fly   320 --------------------DVGHQQVPEIN---------------------------------- 330
                                |....|:.|.:
 Frog   457 QRQRSVPAIKEEYDILDDGGDTAFGQMTEKDANCLEPWLIKEIDACLSDIWLYRDKDAFAQLFHL 521

  Fly   331 ----------KHGYRAAVKIIV-----------------------------------------II 344
                      :|...:|..::|                                         ::
 Frog   522 ISTENVSVDYRHSETSATPLMVAAGQGFLSHVEQLISMGANIQSKASNGWMALDWAKHFGQTEVV 586

  Fly   345 DNMERKAA---------------------IQSRQ-------SYD-----------------EALR 364
            |.:|..:|                     |:.|:       |:|                 :...
 Frog   587 DLLESYSASLETEDLDENTLVQSDGNDLSIEDRELLKAYHHSFDDEKVDLDLIMHVLFNICQITD 651

  Fly   365 YGAVLIFLPGIYEIDTMAENLTCMLEN----DPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKI 425
            .||:||||||..||..:.:.:  :|::    |...:..:....|.|...:|:.|...||.|.|||
 Frog   652 TGAILIFLPGYDEIVGLRDRI--LLDDKRFADNAQRYHVFMLHSNMQTSDQKKVLKLPPAGIRKI 714

  Fly   426 ILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVY 490
            ||:|||||:||||.||.:|||....|.|..|..::.:.|::.|.|||:..||.||.||.|.|..:
 Frog   715 ILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNNVTMLKMVWISKASAIQRKGRAGRCRPGICF 779

  Fly   491 RMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVL-NMGSPV-EILALALSPPNLSDIHNTILLL 553
            |:.:|..:| .|.||..||:||:||....|..|:| .:..|| :.|..|..||....:.|.:.:|
 Frog   780 RLFSKLRFQ-NMLEFQTPELLRIPLHELCLHTKLLVPINCPVADFLMKAPEPPPALIVRNAVQML 843

  Fly   554 KEVGALYLTVDGIYDPLDG--DLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTP 616
            |.:           |.:|.  |||..|..::.||::....::::...|...|:..:.||..|:..
 Frog   844 KTI-----------DAMDNWEDLTEIGHHLADLPVEPHLGKMVLCAVILKCLDPILTIACTLAYR 897

  Fly   617 GLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRF---HV 678
            ..|......||...:......|:.|:.||.:|:.|.:..:.....:|        |.:.|   :.
 Frog   898 DPFVLPSQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKAKSDG--------WERAFCEKNF 954

  Fly   679 SLRSLKEIHL-----LVQELR----VRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNY 734
            ..::..||.:     |:.:||    ||....|.|. .||.|.     |...::|..:....|||.
 Frog   955 LSQATMEIIIGLRTQLLGQLRASGFVRARGGGDIR-DVNINS-----ENWAVVKAALLSGMYPNL 1013

  Fly   735 FTRSKES--------------------------------------CADTDRNIYQTIS-GH---- 756
            ....:|:                                      ...||..:|..:: .|
 Frog  1014 IHVDRENMVLSGVKEKRVRFHPSSALSEPQYKKIPSANCQAEAVQALPTDWLVYDEMTRSHRIAN 1078

  Fly   757 -------DPCRTVYFTNFKPAYMGELYTRRIKE--LFQ-EVRIPPENMDVTFQEGSQKVFVTFKQ 811
                   .|...|.|..  ||   .|.:..:||  .|| ...||.::.|...::.:.....|.|.
 Frog  1079 IKCCSVVTPVTAVLFAG--PA---RLPSSALKEPSSFQVGDGIPNDSSDSEMEDRNTFTLATLKL 1138

  Fly   812 DDWIEGSSKYVPVSGRVQSEV---YKAVMMRQNRVERP---------------IHIMNPSAFMSY 858
            |:|:.  .:..|.:..:..::   ::::.:|  |::.|               |.::|.....:.
 Frog  1139 DEWLH--FRLDPEAAGLLFQLRQKWQSLFLR--RIQAPSKPWSQVDEATIRVIIAVLNTEEQSAG 1199

  Fly   859 VQQ-RGIGD-----------VIEGRWIPPTK----------PLNVELLALPSVFDKTISGSITCI 901
            :|| .|||.           :..||.....|          |.:::.:|.||.|...
 Frog  1200 LQQPSGIGQRPRTLNCEDHLLTSGRINNSQKNFTEAESLDDPSSLDRIAPPSAFSPQ-------- 1256

  Fly   902 VNCGKFFFQPQSFEECIRNMSEIFNAPQQLRNYVT--------NASAIAKGMMVLAKRDSYFQRA 958
               .|:..:..|..:...:.|::.:...:|.:..:        :.|:.|||....:.|.:.|.|.
 Frog  1257 ---AKYKEKGNSLHKWPEDKSDLSSVKYKLSDNSSHPSPCESPSPSSSAKGSNSPSPRQTIFVRY 1318

  Fly   959 TVIRPENQSN 968
            .:::..|..|
 Frog  1319 FIMKSSNLRN 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	210/787 (27%)
		DEXHc_TDRD9	115..295	CDD:350746	80/180 (44%)
		TUDOR	892..1016	CDD:425754	13/85 (15%)
ythdc2	XP_004910524.1	DEXHc_YTHDC2	223..398	CDD:350745	80/180 (44%)
		ANK repeat	535..567	CDD:293786	2/31 (6%)
		ANKYR	<539..>606	CDD:440430	4/66 (6%)
		ANK repeat	569..600	CDD:293786	3/30 (10%)
		OB_NTP_bind	1001..1096	CDD:400182	12/96 (13%)
		YTH	1317..1446	CDD:410979	3/12 (25%)
		R3H_DEXH_helicase	76..134	CDD:100077	14/52 (27%)
		HrpA	222..>1040	CDD:441249	222/851 (26%)