DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Tdrd9

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_083332.1	Gene:	Tdrd9 / 74691	MGIID:	1921941	Length:	1383	Species:	Mus musculus

Alignment Length:	1471	Identity:	466/1471 - (31%)
Similarity:	747/1471 - (50%)	Gaps:	213/1471 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVMDFFDFSKELKRV--AAAPQGYISSDPRLMATKFKSSEVPNRELIGTDYVS-KIVAKEK-CLL 64
            ::.|:|...|.:..|  ...|..:.:..||....  :|.||||.:......|. |..|..: ...
Mouse     9 QINDWFTIGKTVTNVELLGLPPAFPAEAPREEVQ--RSEEVPNEDPTAQAQVPVKATAPARPAST 71

  Fly    65 NGTLLNEQPQG----KRIRTLDDLDTDDEGEETE-----IRR-----------DDEYYKKFRFNL 109
            :|..|:::...    .:.|.|::.:.|..|::..     :|.           .:..||.....:
Mouse    72 SGRSLSQRSSEMEYINKYRQLEEQELDIYGQDQPPSGPGLRSPLAKLSNVACIPETTYKYPDLPI 136

  Fly   110 NRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIA 174
            ||.|        ||:::.|.::.||||.|.||.||:||:|||:||...:...:|||||||||:|.
Mouse   137 NRCK--------EEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYTQRSAFCNIVVTQPRKIG 193

  Fly   175 AISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDE 239
            |.|||..:.:||.|....:..:||||.: .:.|||||:|.||||||..:::.|:|..:|||.:||
Mouse   194 ASSIARWISKERSWTLGGLVGYQVGLEK-IATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIFIDE 257

  Fly   240 VHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFT--TTNSIPPVITTNHRRK-H 301
            ||||.:.|||||:|||:||.||||.||::||||||:.|:.:|||.  ..|.:.|........| |
Mouse   258 VHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCKQFADYFAVPVQNKMNPAYVFEVEGKPH 322

  Fly   302 SIEKFYRDQLGSIIWN------EEDVGHQQVPEINKHGYRAAVKIIVIIDNMERK---------A 351
            :||::|.:.||.|..:      ||       |.|.|..|..||.:|.:.|:::.|         |
Mouse   323 AIEEYYLNDLGHIYHSGLPYRLEE-------PVITKDVYEVAVSLIQMFDDLDMKESGNKTWSGA 380

  Fly   352 AIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFN 416
            ...|.:|        :||:||||:.||:.|.|.||.|:..    ::.:....|.:|.|.|.:||.
Mouse   381 QFVSERS--------SVLVFLPGLGEINYMHELLTNMIHK----RLQVYPLHSSVTLEEQNNVFL 433

  Fly   417 PPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRV 481
            .|.||:|||||:|||||||:|||||.|||||||.:..|.|..:::.||||:||||.:|.||.||.
Mouse   434 SPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCDQRKGRA 498

  Fly   482 GRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDI 546
            ||:..|..||::.:.|:...:|:..:|||||.||.:::||.|:|:||.|..:||.|||||:||||
Mouse   499 GRVSKGYCYRLIPRDFWDSAIPDHVVPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDI 563

  Fly   547 HNTILLLKEVGALYLTVDGIYD---PLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAII 608
            ..||||||||||  |.|.|..:   |.||:||:.|.::::||:..:..:|::||::|..|:|.:|
Mouse   564 ERTILLLKEVGA--LAVSGQREDENPHDGELTFLGRVLAQLPVSQQLGKLVVLGHVFGCLDECLI 626

  Fly   609 IAAGLSTPGLFA-----H-EGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENG--HD 665
            |||.||....|.     | :|.|::      :|  ||..|.||.:|:...:..:....:.|  ..
Mouse   627 IAAALSLKNFFTMPFRQHLDGYRNK------VH--FSGSSRSDCLALVEAFRAWQACRQRGELRR 683

  Fly   666 QESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDRE----KAIMLKVII 726
            .:..:.|.:..::.::.::|:..|.:||:.|.:...:.   |.|:..:.|:|    :..:|:|::
Mouse   684 PKDELDWGRLNYIQIKRIREVAELYEELKNRISQFNMF---VGPHHPVLDQEYPYKQRFILQVVL 745

  Fly   727 AGAFYPNYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPP 791
            ||||||||||..:..    :....:.::|.||..||...:..|  .|.||.::::.||:
Mouse   746 AGAFYPNYFTFGQPD----EEMAVRELAGKDPKTTVVLKHIPP--YGFLYYKQLQSLFR------ 798

  Fly   792 ENMDVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRVQSEVYK-------AVMMRQNRVERPIHI 849
                   |.|..|..|       .:|:..:|..| |..:|.:|       ||.|.|.:|...:.:
Mouse   799 -------QCGQVKSIV-------FDGAKAFVEFS-RNPTERFKTLPAVNLAVKMSQLKVSLELSV 848

  Fly   850 MNPSAFMSYVQQRGIGDVIEGR-----WIPPTKPLNVELLALP---SVFDKTISGSITCIVNCGK 906
            .........||...:..:...|     ......|:.|....|.   :|.|..::..:|.:|..|.
Mouse   849 HAAEEIEGKVQGGSVSKLRNTRVNVDFQKQTVDPMQVSFNTLDRPRTVADLLLTIDVTEVVEVGH 913

  Fly   907 FFFQPQSFEECIRNMSEIFNAPQQLRNYVTNASAIA------KGMMVLA-----KRDSYFQRATV 960
            |:    .:....|| :|:.   :||...:.....:.      ..::.||     .::||| ||.:
Mouse   914 FW----GYRIDERN-AELL---KQLTAEINRLELVPLPIHPHPDLVCLAPFTDYNKESYF-RAQI 969

  Fly   961 IRPENQSNRQPMFYVRFIDYGNCTLLPMQLMRLMPRELTEQYGDLPPRVFECRLAMVQPS--SVV 1023
            :.....|..     |.|:||||.:.:.:.|:    ||:..|:.:||.:..|.::..::||  |::
Mouse   970 LYVSGNSAE-----VFFVDYGNRSHVDLDLL----REIPCQFLELPFQALEFKICKMRPSAKSLI 1025

  Fly  1024 SGNNRWSTAANDMLKT-VAQCGLIDIEVYSLFNNVAAV----------LIHMRDGIINDKLVELM 1077
            .|.: ||..|:..... |..|.|: ::|:|:.::|..|          .:::||.:|.:...||
Mouse  1026 CGEH-WSGGAHGRFAALVGGCPLL-VKVFSIVHSVLHVDVYRYSGAQDAVNVRDVLIREGYAEL- 1087

  Fly  1078 LCRRSDEDYMSRKDHD----FRLRRQESARNLSTAQRQQINEEYLRSCQLPQ--DHDLPPPPLEK 1136
                ::|.|.|::.::    |..:..::..:.|.:...:.:|::|....|..  .:.|..|   .
Mouse  1088 ----AEESYESKQSYEVLKGFFAKSVDTMPDGSVSSPLKDDEKHLLRILLESFASNRLGAP---N 1145

  Fly  1137 CKTVVMLKGPNSPLECTMRSITRVGLSKRVNIDHLSVNALLLDADPQDHHDHLIVAHEIAESRNG 1201
            ||.|  |.||.:|.|....|:||:...:.|.|:..|:|::::...|.|.|..::||..::.:..|
Mouse  1146 CKAV--LHGPFNPYELKCHSLTRISKFRCVWIEKESINSVVISDSPADLHQRMLVAASLSVNETG 1208

  Fly  1202 QTLTARGTTLMPNVQGFGALMVMLFSPTMQLKCNKEGTSYVSVLGGLGCDPDTNEPYFAEHDVLI 1266
            .|:..|.|:|||::.|..||:.|||:|.|:|:.::||..|..||.|||.:..|..|...|||:.:
Mouse  1209 STMLLRETSLMPHIPGLPALLSMLFAPVMELRVDREGKCYTGVLCGLGWNSATEAPILPEHDIEL 1273

  Fly  1267 NLDVNILEDDVILINQIRYYIDSVFFNFKEENNPAVSVNERVS-IYTQLRSLINRLLC--KDRRY 1328
            ..||.:..:|::.||.:|..|:.:..:  ..|.......||:: :....|..:..|.|  |.|..
Mouse  1274 AFDVRLNVEDIVEINILRAAINKLVCD--GPNGSKYLGPERIAQLQENARQKLLGLFCRLKPREK 1336

  Fly  1329 IERNMSNADFEW-ETNPELPLPN-EPFG----KRAIFPMHS 1363
            |........:|| :.:|.|.:.. ||.|    ..:::.:|:
Mouse  1337 ITPQWHEKPYEWNQVDPRLIMEQAEPEGSPGKSTSLYQLHT 1377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	257/612 (42%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	30/134 (22%)
Tdrd9	NP_083332.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..82		12/48 (25%)
		HrpA	111..>717	CDD:224557	263/643 (41%)
		DEXDc	151..292	CDD:238005	80/141 (57%)
		DEAH box. /evidence=ECO:0000269\|PubMed:28633017	256..259		2/2 (100%)
		Helicase_C	384..501	CDD:278689	64/128 (50%)
		HA2	589..666	CDD:214852	30/84 (36%)
		TUDOR	905..1014	CDD:278965	30/126 (24%)
		TUDOR	950..997	CDD:119391	15/56 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847428
Domainoid	1	1.000	172	1.000	Domainoid score	I3703
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14311
Inparanoid	1	1.050	596	1.000	Inparanoid score	I956
Isobase	1	0.950	-	0	Normalized mean entropy	S5414
OMA	1	1.010	-	-		QHG47461
OrthoDB	1	1.010	-	-		D253470at33208
OrthoFinder	1	1.000	-	-		FOG0008277
OrthoInspector	1	1.000	-	-		oto92895
orthoMCL	1	0.900	-	-		OOG6_106475
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4766
SonicParanoid	1	1.000	-	-		X6258
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750