Protein Alignment spn-E and Dhx30

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_001239612.1
• Gene: Dhx30 / 72831
• MGIID: 1920081
• Length: 1223
• Species: Mus musculus
• Alignment Length: 908
• Identity: 250/908 - (27%)
• Similarity: 390/908 - (42%)
• Gaps: 179/908 - (19%)

  Fly    73 PQGKRIRTLDDLDTDDE----GEETEIRRDDEYYKKFRFN---LNRDKNLSIYAKREEILAAINA 130
            |.||....|.|..|...    .|..|:|......:.:|..   ......|.:...|:.||:||..
Mouse   414 PLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQ 478

  Fly   131 HPVVIIKGETGCGKTTQVPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANRVCQEREWQQNTV 193
            ||||:|.|:|||||||::||.:|:.....|:  .||:::||||||:|:|:|.||..|........
Mouse   479 HPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRN 543

  Fly   194 CSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLL 258
            ..|||.|..........||:||.|:||..|.:|.:|...:|:::|||||||.|.|||||:::.|.
Mouse   544 VGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ 608

  Fly   259 ATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGH 323
            ..|.. ::::|||||.|.:..|.||...    |||..........|.:..|.|..:       |.
Mouse   609 RLNPA-LRLVLMSATGDNERFSRYFGGC----PVIKVPGFMYPVKEHYLEDILAKL-------GK 661

  Fly   324 QQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRY------GAVLIFLPGIYEIDTMA 382
            .|.|..::|            ...|.:.|:......|..|..      |.:|.||||..||..:.
Mouse   662 HQYPHRHRH------------HESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQ 714

  Fly   383 ENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDF 447
            :.|...|....: |..|:...|.:...:|:.:|..||.|.|||:|.|||||:||||.|:.:|:|.
Mouse   715 QRLQEALGMHES-KYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDS 778

  Fly   448 CLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLR 512
            .|.|.:..|..:..|.|...|.|:||..||.||.||.:||..|.:..:...::.:| |.:||:||
Mouse   779 GLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVP-FQVPEILR 842

  Fly   513 LPLQNSVLKAKV-LNMGSPVEILALALSPPNLSDIHNTILLLKEVGAL----YLTVDGIYDPLDG 572
            .||:|.||:||: :...:.||.|:.|:..||:..:...::||:|:|.|    |||.
Mouse   843 TPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTT--------- 898

  Fly   573 DLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYI 637
                .|..::.:..|.|.::.|:|..||..|...:::.:.|:.....:....|:::..   :..:
Mouse   899 ----LGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDK---VKAL 956

  Fly   638 FSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFH---------VSLRSLKEIHLLVQEL 693
            .|..||||.:|..|....:          |..:||..|..         :...||:.||.|:::.
Mouse   957 LSHDSGSDHLAFVRAVAGW----------EEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQF 1011

  Fly   694 RVRCTHLGLIPFP-------VNPNQMMDDRE--KAIML-------------KVIIAGAFYPNYFT 736
            ........|:..|       ...|:..::.|  |.:::             ||...|.|.||..|
Mouse  1012 SENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT 1076

  Fly   737 RSKESCADTDRNIYQTISGH------------DPCRTVYFTNFKPAYM-GELYTRRIKELFQEVR 788
                         |:|.||:            ...|:.:.|.|..... |.::.|...::.....
Mouse  1077 -------------YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAV 1128

  Fly   789 IPPENMDVTFQEGSQKVFVTFKQDDW--IEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMN 851
            :...:.||..::..::..::....|.  :||.|:.|.             ::|:.|
Mouse  1129 LLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVR-------------LLREFR--------- 1171

  Fly   852 PSAFMSYVQQRGIGDVIEGRWIPPTKPLNVELLALP-SVFDKTISGSITCIV------NCGKF 907
                      |.:|.::|       :.|..||.||| ||..:  .|.:..::      .||.|
Mouse  1172 ----------RALGRMVE-------RSLRSELAALPLSVQQE--HGQLLALLAELLRGPCGSF 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	195/604 (32%)
		DEXHc_TDRD9	115..295	CDD:350746	79/181 (44%)
		TUDOR	892..1016	CDD:425754	4/22 (18%)
Dhx30	NP_001239612.1	HrpA	455..>987	CDD:441249	190/583 (33%)
		OB_NTP_bind	1044..1131	CDD:400182	17/99 (17%)