DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx30

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001239612.1	Gene:	Dhx30 / 72831	MGIID:	1920081	Length:	1223	Species:	Mus musculus

Alignment Length:	908	Identity:	250/908 - (27%)
Similarity:	390/908 - (42%)	Gaps:	179/908 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PQGKRIRTLDDLDTDDE----GEETEIRRDDEYYKKFRFN---LNRDKNLSIYAKREEILAAINA 130
            |.||....|.|..|...    .|..|:|......:.:|..   ......|.:...|:.||:||..
Mouse   414 PLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQ 478

  Fly   131 HPVVIIKGETGCGKTTQVPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANRVCQEREWQQNTV 193
            ||||:|.|:|||||||::||.:|:.....|:  .||:::||||||:|:|:|.||..|........
Mouse   479 HPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRN 543

  Fly   194 CSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLL 258
            ..|||.|..........||:||.|:||..|.:|.:|...:|:::|||||||.|.|||||:::.|.
Mouse   544 VGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ 608

  Fly   259 ATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGH 323
            ..|.. ::::|||||.|.:..|.||...    |||..........|.:..|.|..:       |.
Mouse   609 RLNPA-LRLVLMSATGDNERFSRYFGGC----PVIKVPGFMYPVKEHYLEDILAKL-------GK 661

  Fly   324 QQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRY------GAVLIFLPGIYEIDTMA 382
            .|.|..::|            ...|.:.|:......|..|..      |.:|.||||..||..:.
Mouse   662 HQYPHRHRH------------HESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQ 714

  Fly   383 ENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDF 447
            :.|...|....: |..|:...|.:...:|:.:|..||.|.|||:|.|||||:||||.|:.:|:|.
Mouse   715 QRLQEALGMHES-KYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDS 778

  Fly   448 CLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLR 512
            .|.|.:..|..:..|.|...|.|:||..||.||.||.:||..|.:..:...::.:| |.:||:||
Mouse   779 GLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVP-FQVPEILR 842

  Fly   513 LPLQNSVLKAKV-LNMGSPVEILALALSPPNLSDIHNTILLLKEVGAL----YLTVDGIYDPLDG 572
            .||:|.||:||: :...:.||.|:.|:..||:..:...::||:|:|.|    |||.
Mouse   843 TPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTT--------- 898

  Fly   573 DLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYI 637
                .|..::.:..|.|.::.|:|..||..|...:::.:.|:.....:....|:::..   :..:
Mouse   899 ----LGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDK---VKAL 956

  Fly   638 FSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFH---------VSLRSLKEIHLLVQEL 693
            .|..||||.:|..|....:          |..:||..|..         :...||:.||.|:::.
Mouse   957 LSHDSGSDHLAFVRAVAGW----------EEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQF 1011

  Fly   694 RVRCTHLGLIPFP-------VNPNQMMDDRE--KAIML-------------KVIIAGAFYPNYFT 736
            ........|:..|       ...|:..::.|  |.:::             ||...|.|.||..|
Mouse  1012 SENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT 1076

  Fly   737 RSKESCADTDRNIYQTISGH------------DPCRTVYFTNFKPAYM-GELYTRRIKELFQEVR 788
                         |:|.||:            ...|:.:.|.|..... |.::.|...::.....
Mouse  1077 -------------YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAV 1128

  Fly   789 IPPENMDVTFQEGSQKVFVTFKQDDW--IEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMN 851
            :...:.||..::..::..::....|.  :||.|:.|.             ::|:.|
Mouse  1129 LLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVR-------------LLREFR--------- 1171

  Fly   852 PSAFMSYVQQRGIGDVIEGRWIPPTKPLNVELLALP-SVFDKTISGSITCIV------NCGKF 907
                      |.:|.::|       :.|..||.||| ||..:  .|.:..::      .||.|
Mouse  1172 ----------RALGRMVE-------RSLRSELAALPLSVQQE--HGQLLALLAELLRGPCGSF 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	195/605 (32%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	4/22 (18%)
Dhx30	NP_001239612.1	DEXDc	467..646	CDD:214692	78/183 (43%)
		DEXDc	481..622	CDD:238005	62/141 (44%)
		HELICc	715..814	CDD:197757	39/99 (39%)
		HA2	886..969	CDD:214852	22/98 (22%)
		OB_NTP_bind	1009..1131	CDD:285018	21/134 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820