DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx34

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001258381.1	Gene:	Dhx34 / 684903	RGDID:	1584452	Length:	1143	Species:	Rattus norvegicus

Alignment Length:	1012	Identity:	249/1012 - (24%)
Similarity:	416/1012 - (41%)	Gaps:	244/1012 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TEIRRDDEYYKKFR--------FNLNRDK---NLSIYAKREEILAAINAHPVVIIKGETGCGKTT 146
            :|.||...:|..|:        ..|.|::   .::.|..|  ||..:..|.||::.|:|||||:|
  Rat   132 SEFRRALLHYLDFQQKQAFGRLAKLQRERAALPIAQYGNR--ILQTLKEHQVVVVAGDTGCGKST 194

  Fly   147 QVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRL 211
            |||||:|     :..:.::..|||||||.||:|.||..|...|..:...:|:......|.. |::
  Rat   195 QVPQYLL-----AAGFSHVACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAA-TKI 253

  Fly   212 LYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDA 276
            ::.|.|:||..:.....|..|..:::||||||..:.||||.|::|||.... .:|:|||||||:.
  Rat   254 VFLTVGLLLRQIQCEPRLPQYQVLIVDEVHERHLHNDFLLGVLQRLLPQRP-DLKVILMSATINI 317

  Fly   277 KELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKII 341
            ...|.||    |..||:.. ..|...|...|:.|          ...|...:..|...|..::::
  Rat   318 SLFSSYF----SHAPVVQV-PGRLFPITVVYQPQ----------EAEQSASKSEKLDPRPFLRVL 367

  Fly   342 VIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTM---AENLTCMLENDPNIKVSIVRCF 403
            ..|||           .|....| |.:|:||.|:.||.|:   |:....:.:     :..::...
  Rat   368 EAIDN-----------KYPPEER-GDLLVFLSGMAEISTVLDAAQAYATLTQ-----RWVVLPLH 415

  Fly   404 SLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTW 468
            |.::..:|..||:..|.|.||.||:|||||:|:|:..:.:|:|....|....|..:....|:..|
  Rat   416 SALSVADQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFW 480

  Fly   469 ASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSP--- 530
            .|:|:..||.||.||...|..||:..:..|....| :.:||:.|:.|...||:.|.:::|.|
  Rat   481 ISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAP-YPVPEIRRVALDALVLQMKSMSVGDPRTF 544

  Fly   531 --VEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRL 593
              :|       ||..:.:...||.|::.|||        |..:. ||..|:::::||:|....::
  Rat   545 PFIE-------PPPAASVETAILYLQDQGAL--------DSSEA-LTPIGSLLAQLPVDVVIGKM 593

  Fly   594 IILGYIFNMLEEAIIIAAGLSTPGLF------------AHEGGRSQLGDSFWMHYIFSDGSGSDL 646
            :|||.:|::.|..:.|||.||....|            |.....|..||.|.:..:|:
  Rat   594 MILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLESDQGDPFTLFNVFN------- 651

  Fly   647 VAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQ 711
              .|    ..:....:|:.:    :|.:|..|....|.|:..|.::.:                :
  Rat   652 --AW----VQVKSERSGNSR----KWCRRRGVEEHRLYEMANLRRQFK----------------E 690

  Fly   712 MMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELY 776
            :::|..       ::.||                     |.::..|            :| ..|.
  Rat   691 LLEDHG-------LLRGA---------------------QVVAPRD------------SY-SRLQ 714

  Fly   777 TRRIKELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWI------EGSSKYVPVSGRVQSEVYKA 835
            .||.::...:::...|      :.|.::..|...|:|..      |||:.....|..:|...:|
  Rat   715 QRRERQTLHQLKRQHE------EGGGRRRKVLRLQEDGCSSDEDHEGSASQRADSVDIQDVKFK- 772

  Fly   836 VMMRQNRVERPIHIMNPSAFMSYVQ-----QRGIGDVIEGRWIPPTKPLNVELLALPSVFDKTIS 895
              :|.|       :....|..|..|     |..:..::.||.:.|.       ||:|..|
  Rat   773 --LRHN-------LEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQ-------LAVPDAF----- 816

  Fly   896 GSITCIVNCGK----FFFQPQSFEECIRNMSEIF-NAPQQLRNYVTNASAIAKGMMVLAKRDSYF 955
                   |.|:    ..|..|:.:..:.:.:.:| |:|:.|......||. .:|     .:|.
  Rat   817 -------NSGRKDSDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGPEASG-REG-----SQDG-- 866

  Fly   956 QRATVIRPENQSNRQPMFYVRFIDYG-----NCTLLP-MQLMRLMPRELTEQYGDLPPRV----F 1010
                  :.:.....|.:.:|..::..     ||..:| :|.:.|..|.: :..||....|    .
  Rat   867 ------KDQMSCKHQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSI-DTNGDCSRLVADGWL 924

  Fly  1011 ECRLAMVQPSSVVSGNN-----RWSTAANDMLKTVAQ 1042
            |.:||..:.:..:...:     .|.:|.:..|...||
  Rat   925 ELQLADSESAVRLLATSLRLRAHWESALDRQLAQQAQ 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	178/606 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	25/138 (18%)
Dhx34	NP_001258381.1	HrpA	155..>687	CDD:224557	180/606 (30%)
Dhx34	NP_001258381.1	OB_NTP_bind	798..909	CDD:400182	27/143 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820