Protein Alignment spn-E and YTHDC2

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: XP_011541883.1
• Gene: YTHDC2 / 64848
• HGNCID: 24721
• Length: 1439
• Species: Homo sapiens
• Alignment Length: 1184
• Identity: 278/1184 - (23%)
• Similarity: 438/1184 - (36%)
• Gaps: 397/1184 - (33%)

  Fly    41 EVPNRELIGTDYVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKF 105
            |..|||:..|              :|.|.|..||                  ..::|.:..:..|
Human   157 EAENREMSKT--------------SGRLNNGIPQ------------------IPVKRGESEFDSF 189

  Fly   106 RFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQP 170
            |      ::|.::.|:|||:..|..:.||:|.||||.|||||:||::||:.:|:|..|.|..|||
Human   190 R------QSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQP 248

  Fly   171 RRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLI-NNKTLTHYTH 234
            ||:|||::|.||..||..:......:|:.|....| ..|.|.:||.||||..|: .:.||:..||
Human   249 RRLAAIAVAERVAAERRERIGQTIGYQIRLESRVS-PKTLLTFCTNGVLLRTLMAGDSTLSTVTH 312

  Fly   235 IVLDEVHERDQNMDFLLIVVRRLLATNSRH--VKIILMSATIDAKELSDYFTTTNSIPPVI---- 293
            :::|||||||:..||||..:|.||   .:|  :|:||.||.:|......||.:.    |||
Human   313 VIVDEVHERDRFSDFLLTKLRDLL---QKHPTLKLILSSAALDVNLFIRYFGSC----PVIYIQG 370

  Fly   294 ---------------TTNHRRKH----------------SIEKFYRDQLGSI------------- 314
                           ||.:..|.                ::.::|..|..|.
Human   371 RPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNV 435

  Fly   315 ----------------------------------------IWNEEDVG------H----QQVPEI 329
                                                    ||..:|:.      |    :.|...
Human   436 TDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVD 500

  Fly   330 NKHGYRAAVKIIV-----------------------------------------IID-------- 345
            .:|...:|..::|                                         |:|
Human   501 YRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSAT 565

  Fly   346 ----NMERKAAIQS----------------RQSYDEA---------LRY--------GAVLIFLP 373
                |::..:.:|:                ..|:|:.         |.|        ||||||||
Human   566 LEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLP 630

  Fly   374 GIYEIDTMAENLTCMLEN----DPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAES 434
            |..||..:.:.:  :.::    |...:..:....|.|...:|:.|...||.|.|||||:|||||:
Human   631 GYDEIVGLRDRI--LFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAET 693

  Fly   435 SITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQ 499
            ||||.||.:|||....|.|..|..:..:.|::.|.|||:..||.||.||.|.|..:|:.::..:|
Human   694 SITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQ 758

  Fly   500 REMPEFGIPEMLRLPLQNSVLKAKVLNMGSPV-----EILALALSPPNLSDIHNTILLLKEVGAL 559
             .|.||..||:||:|||...|..|:|   :||     :.|..|..||....:.|.:.:||.:.|:
Human   759 -NMLEFQTPELLRMPLQELCLHTKLL---APVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAM 819

  Fly   560 YLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGG 624
                    |..: |||..|..::.||::....::::...:...|:..:.||..|:....|.....
Human   820 --------DTWE-DLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQ 875

  Fly   625 RSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRF---HVSLRSLKEI 686
            .||...:......|:.|:.||.:|:.|.:..:.....:|        |.:.|   :...::..||
Human   876 ASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDG--------WERAFCEKNFLSQATMEI 932

  Fly   687 HL-----LVQELR----VRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPN--------- 733
            .:     |:.:||    ||....|.|. .||.|.     |...::|..:....|||
Human   933 IIGMRTQLLGQLRASGFVRARGGGDIR-DVNTNS-----ENWAVVKAALVAGMYPNLVHVDRENL 991

  Fly   734 YFTRSKE-----------------------------SCADTDRNIYQTI------------SGHD 757
            ..|..||                             ....||..||..:            |...
Human   992 VLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVT 1056

  Fly   758 PCRTVYFTNFKPAYMGELYTRRIKE--LFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWI----- 815
            |...:.|..  ||   .|.:..::|  .|:...||.::.|...::.:.......|.|:|:
Human  1057 PVTILVFCG--PA---RLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLE 1116

  Fly   816 -EGSSKYVPVS------------------GRVQSEVYKAVMMRQNRVERPIHIMNPSAFMSYVQQ 861
             |.:|..:.:.                  .:|.....:|::...:..|:...:..||
Human  1117 PEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPS-------- 1173

  Fly   862 RGIGDVIEGRWIPPTKPLNVELLALPSVFDKTISGSITCIVNCGKFFFQPQSFEEC-------IR 919
             |||.        ..:|::.|.|.|.|.:...         |..|.....:..:||       ::
Human  1174 -GIGQ--------RPRPMSSEELPLASSWRSN---------NSRKSSADTEFSDECTTAERVLMK 1220

  Fly   920 NMSEIFNAPQQLRN 933
            :.|...:.||:.::
Human  1221 SPSPALHPPQKYKD 1234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	211/790 (27%)
		DEXHc_TDRD9	115..295	CDD:350746	81/201 (40%)
		TUDOR	892..1016	CDD:425754	7/49 (14%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077
		HrpA	188..>948	CDD:441249	212/796 (27%)
		DEXHc_YTHDC2	193..368	CDD:350745	81/182 (45%)
		ANK repeat	505..537	CDD:293786	2/31 (6%)
		ANK repeat	539..564	CDD:293786	2/24 (8%)
		OB_NTP_bind	971..1066	CDD:400182	14/96 (15%)
		YTH	1289..1404	CDD:410979