DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and dhx8

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	877	Identity:	213/877 - (24%)
Similarity:	359/877 - (40%)	Gaps:	193/877 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVMDFFDFSKELKRVAAAP---QGYISSDPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCLLN 65
            :|.|..|...|::.|...|   :|:......:...|...:  |:..|.....:...:|||:
Zfish   418 KVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPVKIVKN--PDGSLSQAAMMQSALAKER---- 476

  Fly    66 GTLLNEQPQGKRIRTLDDL-------------DTDDEGEETEIR------RDDEYYKKFRFN--- 108
                .|..|.:|...:|.:             |.|.......:|      .|...:||..|.
Zfish   477 ----REVKQAQREAEMDSIPMGLNKHWVDPLPDVDGRQIAANMRGIGMMPNDIPEWKKHAFGGNK 537

  Fly   109 -----------LNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKS-GK 161
                       |.:.::|.||..:|:::.|::.:.::|:.||||.|||||:.||:.:..|.: ||
Zfish   538 ASYGKKTQLSILEQRESLPIYKLKEQLIQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTTRGK 602

  Fly   162 YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINN 226
               |..|||||:||:|:|.||.:|..........:.:......|.| |.:.|.|.|:||...:.:
Zfish   603 ---IGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYTIRFEDCTSPE-TVIKYMTDGMLLRECLID 663

  Fly   227 KTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPP 291
            ..|..|..|:|||.|||..:.|.|..::::.:...: .:|:|:.|||:||.:.|.||...    |
Zfish   664 PDLGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRT-DMKLIVTSATLDAVKFSQYFYEA----P 723

  Fly   292 VITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSR 356
            :.|. ..|.:.:|..|..:                ||.:   |..|..|.|:..::....
Zfish   724 IFTI-PGRTYPVEVLYTKE----------------PETD---YLDASLITVMQIHLTEPP----- 763

  Fly   357 QSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLEN-DPNI-KVSIVRCFSLMTPENQRDVFNPPP 419
                     |.:|:||.|..||||..|.|...::: .|:: ::.|:..:|.:..|.|..:|:|.|
Zfish   764 ---------GDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAP 819

  Fly   420 PGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRL 484
            ||.||:::.|||||:|:|:..:.||:|....|.||.::.:....|.:|..|:|..:|||||.||.
Zfish   820 PGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRT 884

  Fly   485 RSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGS----------PVEILALALS 539
            ..|:.||:..:..|:.||....:||:.|..|.::||..|.:.:..          |:|.|..|:.
Zfish   885 GPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAME 949

  Fly   540 PPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLE 604
            .            |..:|||        |. :|.||..|..|:..||:....:::|:.......|
Zfish   950 Q------------LYTLGAL--------DD-EGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSE 993

  Fly   605 EAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESA 669
            |.:.|.:.||...:|.....:..|.|.....:...:|.          :||.|.:..:..:.:.:
Zfish   994 EMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQPEGD----------HLTLLAVYNSWKNNKFS 1048

  Fly   670 IRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREK---------AIMLKVI 725
            ..|.....:..|||:.    .|::|.:.  ||::           ||.|         .:.::..
Zfish  1049 NPWCYENFIQARSLRR----AQDIRKQM--LGIM-----------DRHKLDVVSCGKATVRVQKA 1096

  Fly   726 IAGAFYPN--------------------------YFTRSKE-----SCADTDRNIYQTISGHDPC 759
            |...|:.|                          .|.|..|     ....|.:...:.::..||
Zfish  1097 ICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDP- 1160

  Fly   760 RTVYFTNFKPAYMGELYTRRIKELFQEVRIPP 791
              .:...|.||:.......|:.:..::.|:.|
Zfish  1161 --RWLVEFAPAFFKVSDPTRLSKQKKQQRLEP 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	168/596 (28%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	189/743 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810