DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx30

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_021322211.1	Gene:	dhx30 / 570735	ZFINID:	ZDB-GENE-130530-833	Length:	1173	Species:	Danio rerio

Alignment Length:	741	Identity:	219/741 - (29%)
Similarity:	346/741 - (46%)	Gaps:	111/741 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EQPQGKRIRT-LDDLDTDD--------------EGEETE--IRRDDEYYKKFRFNLNRDKNLSIY 118
            |:.|...|.| .||.|.|:              |.:|.|  .:|....:|  |....|...|.:.
Zfish   335 EEHQSSSISTAADDYDEDEFITDAITSKPYRALEPKEAEHLSQRLLSMWK--RVGPARGAELPVD 397

  Fly   119 AKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANR 181
            |.:|.||.|:.:..||:|.|||||||||::|:::|::....|:  .||::|||||||:|:|:|.|
Zfish   398 AHKESILEAVRSSQVVVISGETGCGKTTRIPRFLLEDGVLRGEGAECNVLVTQPRRISAVSVAQR 462

  Fly   182 VCQEREWQQNTVCSFQVGLH-RPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQ 245
            |..|..........:||.|. ||.......||:.|.||||..|.:|..|...:|:::|||||||.
Zfish   463 VAHEIGPALQHCVGYQVRLESRPPERSGGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDV 527

  Fly   246 NMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYF------TTTNSIPPVITTNHRRKHSIE 304
            ..|.||.::|.:|:... .:|::||||:.|::.|:.||      .....:.||      |...:|
Zfish   528 QTDLLLHLLRCVLSLRP-ELKVLLMSASGDSQRLAQYFGGCPVLRVPGFMHPV------RARFLE 585

  Fly   305 KFYRD------QLGSIIWNEEDVG------HQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQ 357
            ....|      .:||..|:.|..|      :...|:::        .:..:||::.|..
Zfish   586 DMQLDSRRPLLDMGSTQWSAEVRGRMGKEENNVTPDLD--------LVADVIDHIHRTG------ 636

  Fly   358 SYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGF 422
                  ..||||.||||..||..:.:.|..........:: |:...|.|....|:.||..||.|.
Zfish   637 ------EPGAVLCFLPGWQEIKAVQQQLEEKQAYRSGSQI-ILPLHSSMAVSEQQVVFQRPPAGQ 694

  Fly   423 RKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSG 487
            |||:|.|||||:|||:.|:.:|:|..:.|.:..|..:..|:|...|.|:||..||.||.||.:.|
Zfish   695 RKIVLATNIAETSITIDDIVHVVDAGVQKEQNYDPRTKVSALNTVWISQANVTQRRGRAGRCQPG 759

  Fly   488 RVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVE-ILALALSPPNLSDIHNTIL 551
            ..|.:..:...:| |..|.:||:||.||::.|::||:....|..| .|:..|..|:...:...:.
Zfish   760 HSYHLFPRKQLER-MEPFPVPEILRTPLESVVMQAKIHCPESKAEDFLSQVLDSPDTQAVRTAVK 823

  Fly   552 LLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTP 616
            .|.::|.|         ....|||..|..:|.:..|.|..::::...:|:.::..:.:.|.|:..
Zfish   824 NLMDIGVL---------DASEDLTPLGHHVSCMSCDPRLGKVLVFSALFSCVQPVLSVVACLTRD 879

  Fly   617 GLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVEN---GHDQESAIRWAKRFHV 678
            ..:.....|:.:..:   ....|..||||       ||.:..:|::   .|.::|...:..:..:
Zfish   880 PFYNSLQNRTLVSKA---KAELSGSSGSD-------YLVFSRVVQSWREQHSRDSRQDYLDKHTL 934

  Fly   679 SLRSLKEIHLLVQELRVRCTHLGLIPF---------PVNPNQMMDDREKAIMLKVIIAGAFYPNY 734
            |..||:.||.|:|:........||:..         |||    ...:|:.::..|::|| .|||.
Zfish   935 SGASLRFIHGLMQQFSDNLCEAGLVDHSAECLRLSSPVN----QQSKEEQLITAVLLAG-LYPNL 994

  Fly   735 FTRSKESCADTDR----NI-YQTISG 755
            ....|.....:.|    |: ::|.||
Zfish   995 IQVKKGVVTKSGRFRAENVSFRTESG 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	186/608 (31%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx30	XP_021322211.1	HrpA	371..>929	CDD:224557	185/607 (30%)
dhx30	XP_021322211.1	OB_NTP_bind	947..1069	CDD:311586	19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820