DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx40

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_021322026.1	Gene:	dhx40 / 570225	ZFINID:	ZDB-GENE-080507-1	Length:	734	Species:	Danio rerio

Alignment Length:	698	Identity:	187/698 - (26%)
Similarity:	309/698 - (44%)	Gaps:	112/698 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LDTDDEGEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQV 148
            :.|.....|||              .:..|.|.||..:::::.|:..:..:|:.||||.|||||:
Zfish     1 MSTKKRSSETE--------------HHESKKLPIYQYKDKLVQAVEENTFLIVTGETGSGKTTQL 51

  Fly   149 PQYILDEAYKSGKYCN--IVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRL 211
            |||:    ||:|...|  |.||||||:|||::|.||..|.:.:......:||... ..|.:||.:
Zfish    52 PQYL----YKAGLSRNGRIGVTQPRRVAAITVAQRVSSEMQVRLGEEVGYQVRFD-DCSTKDTMI 111

  Fly   212 LYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSR----HVKIILMSA 272
            .|.|.|.||..::.:.:||.|:.::|||.|||..|.|.||.::::.|...||    .:|:::|||
Zfish   112 KYMTDGCLLREILADPSLTQYSIVILDEAHERSLNTDVLLGLLKKTLLKGSRGNKTPLKVVVMSA 176

  Fly   273 TIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAA 337
            |::.::||.::...    ||.|...|.....|.|.     ::|..::......|.|:.|
Zfish   177 TLETEKLSSFYGNC----PVFTIPGRTYPVKETFC-----NLIGPKDKESSVYVKEVVK------ 226

  Fly   338 VKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLE--------NDPN 394
                :.:|....:||             |.:|:||.|..||:...:.|....|        :|.:
Zfish   227 ----MTLDVHTNEAA-------------GDILVFLTGQSEIEKACDLLFEKAEILDYRYDVHDRS 274

  Fly   395 IK-VSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTA 458
            :. :.|:..:..|..:.||.:|.|.|.|.||.::.||||.:|:|:..:.|::|....|....::.
Zfish   275 VDGLLILSLYGSMPTDQQRQIFQPAPKGVRKCVVATNIAATSLTIDGIRYIVDSGFVKQLNHNSR 339

  Fly   459 SSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAK 523
            .....|.:...||:..:|||||.||..:|:.:|:.:|.|:...|||:.|||:.|..|.:.:|..|
Zfish   340 VGLDILEVVPISKSEAQQRAGRAGRTAAGKCFRIYSKDFWDTCMPEYTIPEIQRTSLTSVILTLK 404

  Fly   524 VLNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLD--GDLTYWGTIMSRLPL 586
            .|.:...:..       |.| |......:|..:..||.     ||.:|  |::|..|.:|...||
Zfish   405 CLGVHDVIRF-------PYL-DCPEERFILTALKQLYQ-----YDAIDRRGEVTKLGRLMVEFPL 456

  Fly   587 DTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWR 651
            ....:|.::........:..:.:||.||...:|...|...:..::...|...:..||..     .
Zfish   457 PPNLTRALLKAAALGCEDIMLPVAAMLSVENIFIRPGKPEKQKEAEVRHKEIAACSGGS-----N 516

  Fly   652 VYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMD-- 714
            .:|..|.:.|.....|:...|.|...:..|::|....:..:||.....|         .|..|
Zfish   517 DFLMLLCVFEKCRASENPSAWCKENWIHWRAVKSAFSVETQLREILLRL---------KQQKDFP 572

  Fly   715 ----DREKAIMLKVIIAGAFYPNYFTRS--KESCADTDRNIYQTISGH 756
                :..::.:|:..:...::.|...||  |..|         |:.||
Zfish   573 HERFEGSRSELLRQCLCLGYFTNVARRSIGKSFC---------TMDGH 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	171/600 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx40	XP_021322026.1	HrpA	15..696	CDD:224557	183/670 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810