Protein Alignment spn-E and DHX33

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_064547.2
• Gene: DHX33 / 56919
• HGNCID: 16718
• Length: 707
• Species: Homo sapiens
• Alignment Length: 686
• Identity: 193/686 - (28%)
• Similarity: 316/686 - (46%)
• Gaps: 100/686 - (14%)

  Fly   113 KNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSG--KYCNIVVTQPRRIAA 175
            ::|.|:..|.::||.:......::.||||.|||||:|||:    |:.|  :...|.||||||:||
Human    72 RSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYL----YEGGISRQGIIAVTQPRRVAA 132

  Fly   176 ISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEV 240
            ||:|.||..|:..:...:..:.|......| ||||:.:.|.|:||...|::..|..|:.::|||.
Human   133 ISLATRVSDEKRTELGKLVGYTVRFDDVTS-EDTRIKFLTDGMLLREAISDSLLRKYSCVILDEA 196

  Fly   241 HERDQNMDFLLIVVRRLLATNSRH-------VKIILMSATIDAKELSDYFTTTNSIPPVITTNHR 298
            |||..:.|.|..||:   |...|.       :|:|:||||:|....|.||   |..|.:....
Human   197 HERTIHTDVLFGVVK---AAQKRRKELGKLPLKVIVMSATMDVDLFSQYF---NGAPVLYLEG-- 253

  Fly   299 RKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEAL 363
            |:|.|:.||..|                |: |.:.:.|.|.:.               |.:.||.
Human   254 RQHPIQVFYTKQ----------------PQ-NDYLHAALVSVF---------------QIHQEAP 286

  Fly   364 RYGAVLIFLPGIYEIDTMAENLTCMLENDPN--IKVSIVRCFSLMTPENQRDVFNPPPPGFRKII 426
            ....:|:||.|..||:.|::....:.::.|:  ..:.::..::.:....|..||...|.|:||:|
Human   287 SSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYRKVI 351

  Fly   427 LTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYR 491
            ::|||||:|||:..:.||:|..:.|.|..:..|....|.:...||....||.||.||..||..||
Human   352 ISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYR 416

  Fly   492 MVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLKEV 556
            :..:..::: ..:..:||:.|..|.:.:|  ::|.|..|..:....:|.|:...|...|..|..:
Human   417 LYTEDEFEK-FDKMTVPEIQRCNLASVML--QLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLL 478

  Fly   557 GALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAH 621
            |||....|.:      .||..|..|:..||:.:.::.|::...|:..||.:.|.:.||...:..:
Human   479 GALEHKDDQL------TLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHN 537

  Fly   622 EGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEI 686
            ...|.:........:|.|:|   |.:.:..:|.|:.|:   |.:::    |.|...|:.:::
Human   538 PPSRREEVQGVRKKFISSEG---DHMTLLNIYRTFKNL---GGNKD----WCKENFVNSKNM--- 589

  Fly   687 HLLVQELRVRCTHLGL-IPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIY 750
             .||.|:|.:...:.| :..|:..::  .|.|.       :......:.|..:.|...|   ..|
Human   590 -TLVAEVRAQLRDICLKMSMPIASSR--GDVES-------VRRCLAHSLFMSTAELQPD---GTY 641

  Fly   751 QTISGHDPC----RTVYFTNFKPA---YMGELYTRR 779
            .|...|.|.    .:|.| :.|||   |...|||.:
Human   642 ATTDTHQPVAIHPSSVLF-HCKPACVVYTELLYTNK 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	173/593 (29%)
		DEXHc_TDRD9	115..295	CDD:350746	71/188 (38%)
		TUDOR	892..1016	CDD:425754
DHX33	NP_064547.2	Required for nucleolar location. /evidence=ECO:0000269|PubMed:26100019	1..80		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..64
		HrpA	73..>700	CDD:441249	193/685 (28%)
		DEAH box	194..197		2/2 (100%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000269|PubMed:26100019	471..562		24/99 (24%)
		Critical for rDNA-binding. /evidence=ECO:0000250	547..558		3/13 (23%)