DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx36

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001122016.2	Gene:	dhx36 / 569072	ZFINID:	ZDB-GENE-050419-20	Length:	1037	Species:	Danio rerio

Alignment Length:	807	Identity:	234/807 - (28%)
Similarity:	379/807 - (46%)	Gaps:	120/807 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DDEGEETEIRRDDE--YYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVP 149
            |:|.::.:.:::|.  |.:..:|.    |.|..|..|||::..|:|:.|::|.|||||||||||.
Zfish   194 DEELKKDQQKKEDNAAYIEMLKFR----KKLPSYGMREELVRLISANRVLVISGETGCGKTTQVT 254

  Fly   150 QYILDEAYK--SGKYCNIVVTQPRRIAAISIANRVCQEREWQ--QNTVCSFQVGLHRPNSLEDTR 210
            |:|||:..:  .|..|.:|.||||||:|||:|.||..||...  :...|.:|:.|......:...
Zfish   255 QFILDDFIQRGQGSLCRVVCTQPRRISAISVAERVAVERAEPVGEGKSCGYQIRLQSRLPRKQGS 319

  Fly   211 LLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATID 275
            ||||||||:|..|.::..|:..||:||||:|||....|.|:.:|:.|| |....:|::|||||::
Zfish   320 LLYCTTGVILQWLHSDPYLSSITHLVLDEIHERSVQSDILITIVKDLL-TARDDLKVVLMSATLN 383

  Fly   276 AKELSDYFTTTNSIP---------PVI--------------------TTNHRRKHSIEKFYRDQL 311
            |::.|.||   |:.|         ||.                    ..::|::::.....|.:.
Zfish   384 AEKFSKYF---NNCPMIHIPGYTFPVTEYLLEDVVELLGFQPRYKQRKPHYRKRNNHGSSARPEK 445

  Fly   312 GSIIWNEEDVGHQQVP----EINKHGYRAAVKIIVIID-----NMERKAAIQSRQSYDEALRYGA 367
            |.|    |...|:..|    .:........::::.::|     ::|..||:....:.:|  ..||
Zfish   446 GKI----EAKYHESWPCYARTLRDRFSDTTIEVLGMMDDDDNIDLELTAALIRHIAVNE--NEGA 504

  Fly   368 VLIFLPGIYEIDTMAENLTCMLENDPNIKVS-----IVRCFSLMTPENQR-------DVFNPPPP 420
            :|:||||...|.|:.:    :|.:|...|..     |:...|||...:|.       .||..|||
Zfish   505 ILVFLPGWDNISTLND----LLMSDQMFKSGRYRFIIIPLHSLMPTVSQTQVISLFPQVFKKPPP 565

  Fly   421 GFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVT--DTASSFSSLRLTWASKANCRQRAGRVGR 483
            |.|||::.|||||:|||:.||.||||.  .|:|.|  ||.::..::...|.|.||.:||.||.||
Zfish   566 GVRKIVIATNIAETSITIDDVVYVIDG--GKIKETHFDTQNNIRTMTAEWVSIANAKQRKGRAGR 628

  Fly   484 LRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHN 548
            :..|:.|.:.| ......:..:.:||:.|.||:...|:.|||.:|.....|...:.||:...|..
Zfish   629 VSPGKCYHLYN-GLRASLLDNYQLPEIQRTPLEELCLQIKVLKLGPIATFLQKTMDPPSDRAIEL 692

  Fly   549 TILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGL 613
            .|..|.::.||         ..|..||..|..::|:|::....::|:.|.:...|:..:.|||.|
Zfish   693 AITHLVDLNAL---------DRDEKLTPLGFHLARMPVEPHIGKMILFGALLGCLDPVLTIAASL 748

  Fly   614 STPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHV 678
            |....|....|:.::.|.  ...:||..|.||.::|...:|.:.:....|...|....|..  .:
Zfish   749 SFKDPFFIPLGKEKIADQ--RRKMFSQNSRSDHLSIVNAFLGWEDAKRRGSRFEREYCWDN--FL 809

  Fly   679 SLRSLKEIHLLVQELRVRCTHLGLI--PFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKES 741
            |..:|:.:..:..:........|.:  ..|.:|:..::...|.::..||:|| .||..   :|.|
Zfish   810 SANTLQMLQNMKGQFAEHLLRAGFVNSKDPKDPSSNINSENKKLVKAVIVAG-LYPKV---AKIS 870

  Fly   742 CADTDR-----NIYQTISG----HDPCRTVYFTNFKPAYMGELYTRRIKE----LFQEVRIPPEN 793
            .:...:     .:|....|    |........|.|:  |...:|..::|.    |:....:.|.:
Zfish   871 PSHNKKRPMPVKVYTKADGKVCIHPKSVNAEETQFQ--YKWLVYHLKMKTTSIFLYDCTEVSPFS 933

  Fly   794 M-----DVTFQEGSQKVFVTFKQDDWI 815
            :     :::.|....:  .|...|:||
Zfish   934 LLFFGGNISIQRDQDQ--DTIAVDEWI 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	202/639 (32%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx36	NP_001122016.2	HrpA	193..992	CDD:224557	234/807 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920