DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx34

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_017207416.1	Gene:	dhx34 / 555838	ZFINID:	ZDB-GENE-061207-30	Length:	1154	Species:	Danio rerio

Alignment Length:	892	Identity:	230/892 - (25%)
Similarity:	372/892 - (41%)	Gaps:	234/892 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RIRTLDDLDTDDE---GEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKG 138
            |:..|..||.:.:   .:.:::||:             .|:|.|:..|::|:..:..||||::.|
Zfish   134 RLALLHFLDFNQKQSFSKLSKLRRE-------------QKSLPIFQYRDKIVELVRTHPVVVVAG 185

  Fly   139 ETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRP 203
            :|||||:||||||:|.....     ||..|||||||.||:|.||..|...|..:...:|:.....
Zfish   186 DTGCGKSTQVPQYLLASGIN-----NIACTQPRRIACISLAKRVSFESLNQYGSKVGYQIRFETS 245

  Fly   204 NSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKII 268
            .:|. |:||:.|.|:||..:..:.:|..|..:::||||||..:.||||.|:|.||:... .::::
Zfish   246 RTLA-TKLLFLTEGLLLRQIQQDASLGQYQVLIVDEVHERHLHCDFLLGVLRSLLSLRP-DLRLV 308

  Fly   269 LMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHG 333
            ||||||:.|..|.||...    ||:.. ..|...|:..|:.     |..||     ||....|..
Zfish   309 LMSATINIKLFSSYFNDA----PVLQV-PGRLFPIQVIYQP-----IPPEE-----QVSRSEKLD 358

  Fly   334 YRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVS 398
            .|..::::..||           |.|.:..| |.:|:||.|:.||.|:.|  .|........:..
Zfish   359 PRPYLRVLQGID-----------QRYPQEER-GDLLLFLSGVAEISTIQE--ACQTYATHTQRWI 409

  Fly   399 IVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSS 463
            ::...|.::...|..||:..|||.||.|::|||||:|:|:..|.:|:|....|....|..:....
Zfish   410 VLPLHSTLSLAQQDKVFDIAPPGVRKCIISTNIAETSVTIDGVRFVVDSGKVKEMSFDPKAKMQR 474

  Fly   464 LRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMG 528
            |:..|.|:|:..||.||.||...|..||:.::..|....| :.:||:.|:.|.:.:|:.|.:.:|
Zfish   475 LQEFWISRASSEQRKGRAGRTGPGVCYRLYSESDYDAFAP-YPVPEIHRVALDSLILQMKSMGLG 538

  Fly   529 SPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRL 593
            .|...  ..:.||..|.|...:..|:|.|||         ...|:||..|.::::||:|....::
Zfish   539 DPRTF--TFIDPPPASSIQTAVTYLREQGAL---------DEHGELTSIGRLLAQLPVDVVIGKM 592

  Fly   594 IILGYIFNMLEEAIIIAAGLSTPGLF------------AHEGGRSQLGDSF--------WMHYIF 638
            ::||.:||::|..:.:||.||....|            |.:...|..||.|        |:....
Zfish   593 LVLGSVFNLVEPVLTVAAALSVQSPFLRSAQHNPDCSTARQPLNSNHGDPFTLMNTFNAWVQVKA 657

  Fly   639 SDGSGS---------------DLVAIWRVYLTYL---NIVEN----GHDQESAIRWAKRF--HVS 679
            ..||||               ::|.:.|.:...|   .::|:    ..:.:...|..:||  ...
Zfish   658 DRGSGSRKWCRRRGLEEQRLYEMVNLRRQFKELLRSHGLLEDDTGRATEPQDRARRRERFTERQK 722

  Fly   680 LRSLKEIHLL--------------------------------------------VQELRVRCTHL 700
            |..||..|.|                                            :||::.:..|
Zfish   723 LHQLKRDHELQENTKRKVLRLEEGLEGDASSGSDAEESSTSRKKRKDGAEQTMDIQEVKFKLRH- 786

  Fly   701 GLIPFPVNPNQMMDDRE--------KAIMLKVIIAGAFYPN-----------------YFTRSKE 740
                   |.|::.:...        :..:||:::....||.                 :.||:|:
Zfish   787 -------NVNELQESAYASAALSSLQQALLKLLLCRGLYPQLAIPDEHNATRKDSDQVFHTRNKQ 844

  Fly   741 SCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMDVTFQEGSQK- 804
            .......:::.:    ||                           ||...||:  .|.:.|:.|
Zfish   845 GVVIHPTSVFAS----DP---------------------------EVLHVPEH--ETSEFGTDKG 876

  Fly   805 --------VFVTFKQDDWIEGSSKYVPVSGRVQSEVYKAVMMRQNRV 843
                    .|||.     :|.:..|  :|..|:....:|:::..|.|
Zfish   877 QSNRHQLLAFVTL-----LETNKPY--LSNCVRVPALQALLLVANSV 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	195/671 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx34	XP_017207416.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820