Protein Alignment spn-E and DHX29

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_061903.2
• Gene: DHX29 / 54505
• HGNCID: 15815
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 896
• Identity: 249/896 - (27%)
• Similarity: 420/896 - (46%)
• Gaps: 156/896 - (17%)

  Fly    52 YVSKIVAKEKCLLNGTLLNEQPQGKRIRTLDDLDTDDEGEET--EIRRDDEY------------- 101
            :::|::.|         |.:|.|.::..:.:..:..::.||:  .:..|:::
Human   491 FIAKLLNK---------LKQQQQQQQQHSENKRENSEDPEESWENLVSDEDFSALSLESANVEDL 546

  Fly   102 ---------------YKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQY 151
                           |:|.   |...:.|.::..|:.|:..:..|.||::.||||.||:||||.:
Human   547 EPVRNLFRKLQSTPKYQKL---LKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHF 608

  Fly   152 ILDE----AYKSGKYCNIVVTQPRRIAAISIANRVCQEREWQ-----QNTVCSFQVGLHRPNSLE 207
            :|::    .:::.| ||||.||||||:|:|:|||||.|...:     :|::|.:|:.: ...:.|
Human   609 LLEDLLLNEWEASK-CNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCGYQIRM-ESRACE 671

  Fly   208 DTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSA 272
            .||||||||||||..|..:..|::.:|:::||||||....|||||:::.:|...| .:.:|||||
Human   672 STRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKEILQKRS-DLHLILMSA 735

  Fly   273 TIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQL---------------GSIIWNEEDV- 321
            |:|:::.|.|||..    |::..: .|.:.:|.|:.:.:               ...:..||:|
Human   736 TVDSEKFSTYFTHC----PILRIS-GRSYPVEVFHLEDIIEETGFVLEKDSEYCQKFLEEEEEVT 795

  Fly   322 ----------------------GHQQV-PEINKHGYRAAVKIIVIIDNMERKAAIQSRQSY-DEA 362
                                  .|..: |...|:..|....|:.:..:......|....:| |::
Human   796 INVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYMNPHKINLDLILELLAYLDKS 860

  Fly   363 LRY----GAVLIFLPGIYEIDTMAENLTCMLENDPNI---KVSIVRCFSLMTPENQRDVFNPPPP 420
            .::    |||||||||:..|    :.|..:|.||...   :..::...|:::.::|...|..|||
Human   861 PQFRNIEGAVLIFLPGLAHI----QQLYDLLSNDRRFYSERYKVIALHSILSTQDQAAAFTLPPP 921

  Fly   421 GFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLR 485
            |.|||:|.|||||:.||:|||.:|||....|......:|..|||..|:.|||:..||.||.||:|
Human   922 GVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVR 986

  Fly   486 SGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTI 550
            .|..:||..:..::..| ::.:||:||:||:...|.....|:|||.:.|:.||.||.|..|.|.:
Human   987 DGFCFRMYTRERFEGFM-DYSVPEILRVPLEELCLHIMKCNLGSPEDFLSKALDPPQLQVISNAM 1050

  Fly   551 LLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLST 615
            .||:::||..|.        :..||..|..::.||::.:..:::|.|.||..|:....:||.::.
Human  1051 NLLRKIGACELN--------EPKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTE 1107

  Fly   616 PGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSL 680
            ...|....||....|........:|   ||.:.|:..||.:....:.| ...|.|.:.:|..::.
Human  1108 KSPFTTPIGRKDEADLAKSALAMAD---SDHLTIYNAYLGWKKARQEG-GYRSEITYCRRNFLNR 1168

  Fly   681 RSLKEIHLLVQELRVRCTHLGLIPFPVN-------PNQMMDDREKAIMLKVIIAGAFYPN----Y 734
            .||..:..:.|||.......|......:       .:|.:..:|.|::..|::|| .|.|    .
Human  1169 TSLLTLEDVKQELIKLVKAAGFSSSTTSTSWEGNRASQTLSFQEIALLKAVLVAG-LYDNVGKII 1232

  Fly   735 FTRS-----KESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENM 794
            :|:|     |.:|      |.:|..|...............:...||..:|:  :..|.:....:
Human  1233 YTKSVDVTEKLAC------IVETAQGKAQVHPSSVNRDLQTHGWLLYQEKIR--YARVYLRETTL 1289

  Fly   795 DVTFQEGSQKVFVTFKQDDWIEGSSKYVPVSGRV--QSEVYKAVMMRQNRV 843
            ...|.      .:.|..|..::...:.:.:.|.:  |:.|..||:.:|.||
Human  1290 ITPFP------VLLFGGDIEVQHRERLLSIDGWIYFQAPVKIAVIFKQLRV 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	207/638 (32%)
		DEXHc_TDRD9	115..295	CDD:350746	80/188 (43%)
		TUDOR	892..1016	CDD:425754
DHX29	NP_061903.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..75
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..226
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..526		4/23 (17%)
		HrpA	571..>1271	CDD:441249	223/731 (31%)
		DEXHc_DHX29	572..754	CDD:350733	80/188 (43%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03068	702..705		2/2 (100%)