DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and Dhx30

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	XP_006243888.1	Gene:	Dhx30 / 367172	RGDID:	1308888	Length:	1222	Species:	Rattus norvegicus

Alignment Length:	908	Identity:	250/908 - (27%)
Similarity:	390/908 - (42%)	Gaps:	179/908 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PQGKRIRTLDDLDTDDE----GEETEIRRDDEYYKKFRFN---LNRDKNLSIYAKREEILAAINA 130
            |.||....|.|..|...    .|..|:|......:.:|..   ......|.:...|:.||:||..
  Rat   413 PLGKDSGPLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQ 477

  Fly   131 HPVVIIKGETGCGKTTQVPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANRVCQEREWQQNTV 193
            ||||:|.|:|||||||::||.:|:.....|:  .||:::||||||:|:|:|.||..|........
  Rat   478 HPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRN 542

  Fly   194 CSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLL 258
            ..|||.|..........||:||.|:||..|.:|.:|...:|:::|||||||.|.|||||:::.|.
  Rat   543 VGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ 607

  Fly   259 ATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGH 323
            ..|.. ::::|||||.|.:..|.||...    |||..........|.:..|.|..:       |.
  Rat   608 RLNPA-LRLVLMSATGDNERFSRYFGGC----PVIKVPGFMYPVKEHYLEDILAKL-------GK 660

  Fly   324 QQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRY------GAVLIFLPGIYEIDTMA 382
            .|.|..::|            ...|.:.|:......|..|..      |.:|.||||..||..:.
  Rat   661 HQYPHRHRH------------HESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQ 713

  Fly   383 ENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDF 447
            :.|...|....: |..|:...|.:...:|:.:|..||.|.|||:|.|||||:||||.|:.:|:|.
  Rat   714 QRLQEALGMHES-KYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDS 777

  Fly   448 CLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLR 512
            .|.|.:..|..:..|.|...|.|:||..||.||.||.:||..|.:..:...::.:| |.:||:||
  Rat   778 GLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVP-FQVPEILR 841

  Fly   513 LPLQNSVLKAKV-LNMGSPVEILALALSPPNLSDIHNTILLLKEVGAL----YLTVDGIYDPLDG 572
            .||:|.||:||: :...:.||.|:.|:..||:..:...::||:|:|.|    |||.
  Rat   842 TPLENLVLQAKIHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTT--------- 897

  Fly   573 DLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYI 637
                .|..::.:..|.|.::.|:|..||..|...:::.:.|:.....:....|:::..   :..:
  Rat   898 ----LGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDK---VKAL 955

  Fly   638 FSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFH---------VSLRSLKEIHLLVQEL 693
            .|..||||.:|..|....:          |..:||..|..         :...||:.||.|:::.
  Rat   956 LSHDSGSDHLAFVRAVAGW----------EEVLRWQDRTSRENYLEENLLYAPSLRFIHGLIKQF 1010

  Fly   694 RVRCTHLGLIPFP-------VNPNQMMDDRE--KAIML-------------KVIIAGAFYPNYFT 736
            ........|:..|       ...|:..::.|  |.:::             ||...|.|.||..|
  Rat  1011 SENIYEAFLVGKPSDCTLPSAQCNEYSEEEELVKGVLMAGLYPNLIQVRQGKVTRQGKFKPNSVT 1075

  Fly   737 RSKESCADTDRNIYQTISGH------------DPCRTVYFTNFKPAYM-GELYTRRIKELFQEVR 788
                         |:|.||:            ...|:.:.|.|..... |.::.|...::.....
  Rat  1076 -------------YRTKSGNILLHKSTINREATRLRSRWLTYFMAVKSNGSVFVRDSSQVHPLAV 1127

  Fly   789 IPPENMDVTFQEGSQKVFVTFKQDDW--IEGSSKYVPVSGRVQSEVYKAVMMRQNRVERPIHIMN 851
            :...:.||..::..::..::....|.  :||.|:.|.             ::|:.|
  Rat  1128 LLLTDGDVHIRDDGRRATISLSDSDLLRLEGDSRTVR-------------LLRELR--------- 1170

  Fly   852 PSAFMSYVQQRGIGDVIEGRWIPPTKPLNVELLALP-SVFDKTISGSITCIV------NCGKF 907
                      |.:|.::|       :.|..||.||| ||..:  .|.:..::      .||.|
  Rat  1171 ----------RALGRMVE-------RSLRSELAALPLSVQQE--HGQLLALLAELLRGPCGSF 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	195/605 (32%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449	4/22 (18%)
Dhx30	XP_006243888.1	DEXDc	466..645	CDD:214692	78/183 (43%)
		DEXDc	480..621	CDD:238005	62/141 (44%)
		HELICc	714..813	CDD:197757	39/99 (39%)
		HA2	885..968	CDD:214852	22/98 (22%)
		OB_NTP_bind	1008..1130	CDD:285018	21/134 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820