Protein Alignment spn-E and Dhx57

DIOPT Version :10

• Sequence 1: NP_476741.1
• Gene: spn-E / 41919
• FlyBaseID: FBgn0003483
• Length: 1434
• Species: Drosophila melanogaster
• Sequence 2: NP_001178836.1
• Gene: Dhx57 / 366532
• RGDID: 1310340
• Length: 1391
• Species: Rattus norvegicus
• Alignment Length: 955
• Identity: 257/955 - (26%)
• Similarity: 427/955 - (44%)
• Gaps: 199/955 - (20%)

  Fly    53 VSKIVAKEKCLLNGTLL-NEQPQGKRIRTLDDLDTDDEGEETEIRRDDEYY-------------- 102
            :||...::..:.:.|.| |:..:|:.:..|::...:|||....:..::.|.
  Rat   451 ISKPAYRKPVIPSNTFLSNQMLEGEGLSELEEDADEDEGPAPIVVENESYVNLKKRSYRRCDRPA 515

  Fly   103 --------------------KKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQ 147
                                ::|...|...:.|..:.:||.||..::.|.||:|.|.||||||||
  Rat   516 KSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGCGKTTQ 580

  Fly   148 VPQYILDEAYKS--GKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTR 210
            :||:|||.:...  .:..||:.||||||:|||:|.||.:||..:......:|:.|....| ..||
  Rat   581 IPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKS-SATR 644

  Fly   211 LLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATID 275
            ||||||||||..|..:.||...|||::||||||.:..||||:|::.::...:. :::||||||:|
  Rat   645 LLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLLLVLKDIVMQRAT-LQVILMSATLD 708

  Fly   276 AKELSDYFTTTNSIPPVIT-------------------------------------------TNH 297
            |...|.||    |..||||                                           ..|
  Rat   709 AGLFSKYF----SYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSPYMRSMKQIAKERLKARH 769

  Fly   298 RRKHSIEKFYRD-QLGSIIWNEEDVGHQQVPE---------INKHGY-RAAVKIIVIID----NM 347
            .|. ::|:...| :|...:.:||:.....:|:         :...|. ::.:|.:.::|    |:
  Rat   770 NRT-ALEEVEEDLRLALHLQDEEESVKDTIPDQQLDFKQLLVRYKGVSKSVIKTMSVMDFEKVNL 833

  Fly   348 ERKAA-----IQSRQSYDEALRYGAVLIFLPGIYEIDTMAENL--TCMLENDPNIKVSIVRCFSL 405
            |...|     :..:.||..    ||:|:||||:.||..:.|.|  ..:..|..:.:..|....|.
  Rat   834 ELIEALLEWIVDGKHSYPP----GAILVFLPGLAEIKMLYEQLQSNSLFNNRRSHRCVIHPLHSS 894

  Fly   406 MTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWAS 470
            ::.|.|:.||..||.|..|||::|||||:|||:.||.||||....|.|..|......||..|:.|
  Rat   895 LSSEEQQAVFVKPPLGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDAGKGMESLEDTFVS 959

  Fly   471 KANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSP---VE 532
            :||..||.||.||:.||..:.:...|.|..::.:..:||:.|:||:...|:.|:|.|.|.   ..
  Rat   960 QANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSTHNLQS 1024

  Fly   533 ILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILG 597
            :.:..:.||::..:..:.:.|:::|||        .| |..||..|..::.||:|.|..:|::||
  Rat  1025 VFSRLIEPPHVDSLRASKVRLRDLGAL--------TP-DEKLTPLGYHLASLPVDVRIGKLMLLG 1080

  Fly   598 YIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTY-LNIVE 661
            .||..|:.|:.|||.|:....|.....:.:..:...:.:.|::   ||.:|:...|..: |:..|
  Rat  1081 SIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFAN---SDYLALLCAYKGWQLSTKE 1142

  Fly   662 NGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQ----------MMD-- 714
            :.   .::..:.::..:|.|:|:|:..|.::.....:.:|.:...:...:          ::|
  Rat  1143 SA---RASYNYCRQNFLSGRTLQEMASLKRQFTELLSDIGFVKEGLRAKEIEKRAQGGDGVLDAT 1204

  Fly   715 ------DREKAIMLKVIIAGAFYPNYF--------------------TRSKESCADTDRNIYQTI 753
                  :.|...::..::..|.|||..                    .:|.|....|..:.|..|
  Rat  1205 GEEANTNAENPKLISAVLCAALYPNVVQVKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHI 1269

  Fly   754 SGHDPCRTVYFTNFKPAYMGELYTRRIK------------ELFQEVRIPPENMDVTFQEGSQKVF 806
              |.........:|...|:  ||..:||            .::..|......:.|..|.|:   |
  Rat  1270 --HPSSVNYQVRHFDSPYL--LYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVSVQLQRGA---F 1327

  Fly   807 VTFKQDDWIEGSSKYVPVSGRVQSEVYKAV-----MMRQNRVERP 846
            |....|.||    ::|..|.:| :|:.|.:     .:.|::::.|
  Rat  1328 VVSLDDGWI----RFVAASHQV-AELVKELRCELDQLLQDKIKNP 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	114..>697	CDD:441249	209/653 (32%)
		DEXHc_TDRD9	115..295	CDD:350746	87/224 (39%)
		TUDOR	892..1016	CDD:425754
Dhx57	NP_001178836.1	UBA_DHX57	184..221	CDD:270502
		RWD_DHX57	245..428	CDD:467661
		zf_CCCH_4	308..326	CDD:465719
		HrpA	548..>1175	CDD:441249	209/652 (32%)
		OB_NTP_bind	1218..1315	CDD:400182	17/100 (17%)