DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and Dhx32

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001123511.1	Gene:	Dhx32 / 361667	RGDID:	1311740	Length:	751	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	184/804 - (22%)
Similarity:	320/804 - (39%)	Gaps:	167/804 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NEQPQGKRI--RTLDDLDTDDEG----EETEIRRDD------EYYKKFRFNLNRDKNLSIYAKRE 122
            |..|: ||.  .:||..|.|:||    |:.|:...|      .|||.    |...:.|.|:.::.
  Rat    17 NASPE-KRYFPESLDSSDGDEEGVLACEDLELNPFDGLPYSSRYYKL----LKEREELPIWKEKY 76

  Fly   123 EILAAINAHPVVIIKGETGCGKTTQVPQ----YILDEAYKSGKYCNIVVTQPRRIAAISIANRVC 183
            ..:.::..:.||::.|::.|||::||||    |.|...|:.|   .::.||..:..|:.:|.||.
  Rat    77 SFMESLLQNQVVLVSGDSKCGKSSQVPQWCAEYCLSIHYQHG---GVICTQVHKQTAVQLALRVA 138

  Fly   184 QEREWQQNTVCSFQVGLHRPNS---LEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQ 245
            .|    .:.....:||...|..   ..:|.|.|||..:|...:::|..|..|..|:||:||||..
  Rat   139 DE----MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSL 199

  Fly   246 NMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQ 310
            ..|.||.:::.:|.... .:|:|:..:......||.|:...    |::..  |.||.:|..|..
  Rat   200 ATDVLLGLLKDVLLARP-ELKLIINCSPFLISRLSSYYGNV----PLLEV--RNKHPVEVVYLS- 256

  Fly   311 LGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGI 375
                       |.|:.|      :.:.|::|..|.....:               |.|::||...
  Rat   257 -----------GAQKDP------FESVVRLIFEIHRSGEQ---------------GDVVVFLACE 289

  Fly   376 YEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPP-------PPGFRKIILTTNIAE 433
            .:|:...| :.|...::.|..|..:....|. |:.:..:|.|.       ....|:::|||:..|
  Rat   290 QDIEKTYE-IVCQEGSNLNPDVGELVVIPLY-PKEKCSLFRPVDETEKRCQASQRRVVLTTSCGE 352

  Fly   434 SSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFY 498
            |.|....|.:|||..|.:.:|.:.....:||.|...|::....|...:|...||:::.:..:.|.
  Rat   353 SLIWSHTVRFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFA 417

  Fly   499 QREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALA----LSPPNLSDIHNTILLLKEVGAL 559
            .::|......||....|.:.||..|      .|:|..|.    ::.|....:...:..|..:.||
  Rat   418 SKDMRPLKPAEMQEANLTSMVLFMK------RVDIAGLGRCDFMNRPAPESLMQALEDLDYLAAL 476

  Fly   560 YLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLFAH-EG 623
                |.     ||:|:.:|.|||..|||.:.|:.|:....|:.::|.:.|||.::.|..|.| ..
  Rat   477 ----DN-----DGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPH 532

  Fly   624 GRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHL 688
            |..:...:.|..::..:|....|:   .:|..|.:.|.|..::.....|.....:|..:|:...:
  Rat   533 GAEEAAVTCWKTFLHPEGDHFTLI---NIYNAYQDTVLNSANEHCVETWCHNCFLSCSALRMADV 594

  Fly   689 LVQEL-----RVRCTHLGLIPFPVNPNQMMDDREKAIML-KVIIAGAFYP---------NYFTRS 738
            :..||     |:.      :|:   .......:|..:.: |.:::|.|..         ||...:
  Rat   595 IRAELLEIIKRIE------LPY---AEPAFGSQENGLNIKKALLSGYFMQIARDVDGSGNYLMLT 650

  Fly   739 KESCAD------------------------TDRNIYQTISGHDP------CRTVYFTNFKPAYMG 773
            .:..|.                        ::.|..:..|...|      ....||:|..|:
  Rat   651 HKQVAQLHPLSSYAITKKMPEWVLFHQFSISENNYIRVTSAVSPELFMQLVPQYYFSNLPPS--- 712

  Fly   774 ELYTRRIKELFQEV--RIPPENMD 795
                 ..|::.|:.  .:|...||
  Rat   713 -----ESKDILQQASGHLPTTAMD 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	147/607 (24%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
Dhx32	NP_001123511.1	HrpA	19..687	CDD:224557	172/748 (23%)
		DEXDc	86..202	CDD:238005	40/122 (33%)
		HA2	472..556	CDD:214852	26/92 (28%)
		OB_NTP_bind	597..704	CDD:285018	14/115 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900