DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and mle

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_476641.1	Gene:	mle / 35523	FlyBaseID:	FBgn0002774	Length:	1293	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	244/783 - (31%)
Similarity:	371/783 - (47%)	Gaps:	153/783 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TLDDLDTDDEGEETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGK 144
            ::|||..|.|....:.|::|..|::|   |...:.|.|.|.|.|||.|||.:|||||:|.|||||
  Fly   352 SIDDLSMDYERSLRDRRQNDNEYRQF---LEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGK 413

  Fly   145 TTQVPQYILDEAYKSGK--YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLH----RP 203
            |||:.|||||:...||:  |.||.|||||||:|||:|.||.:||..|......:.|...    ||
  Fly   414 TTQIAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVGYSVRFESVFPRP 478

  Fly   204 NSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKII 268
            ..    .:|:||.||||..|  ...|...:||::||:||||.|.||||:::|.::.|.. .:.:|
  Fly   479 YG----AILFCTVGVLLRKL--EAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYP-DLHVI 536

  Fly   269 LMSATIDAKELSDYFTTTNSIPPVI--------------------------TTNHRRKHSIEKFY 307
            |||||||..:.|.||    .|.||:                          ..:.|::..:|.
  Fly   537 LMSATIDTTKFSKYF----GICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESRRKRKEVED-- 595

  Fly   308 RDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYD--EALRY----- 365
            .:||.|...:|.::.:.:|.| :|:..:....:.::         .:|..|::  |||..
  Fly   596 EEQLLSEDKDEAEINYNKVCE-DKYSQKTRNAMAML---------SESDVSFELLEALLMHIKSK 650

  Fly   366 ---GAVLIFLPG---IYEIDTMAENLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRK 424
               ||:|:||||   |:.:....:|.....:..   :..|:.|.|.:..:.||.||.|.|.|..|
  Fly   651 NIPGAILVFLPGWNLIFALMKFLQNTNIFGDTS---QYQILPCHSQIPRDEQRKVFEPVPEGVTK 712

  Fly   425 IILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRV 489
            |||:|||||:|||:.|:.:|||.|.|::|:..:.::.:|....||||.|..||.||.||:|.|..
  Fly   713 IILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRKGRAGRVRPGFC 777

  Fly   490 YRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILLLK 554
            :.:.::..:| .:.:...|||.|.||....|..|:|.:||....|:.||.||.:..:....:||:
  Fly   778 FTLCSRARFQ-ALEDNLTPEMFRTPLHEMALTIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLR 841

  Fly   555 EVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLST-PGL 618
            |:..|        |..| :||..|.:::|||::.|..::::||.:|...:...|:|:..|| ..:
  Fly   842 EMRCL--------DAND-ELTPLGRLLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEV 897

  Fly   619 FAHEGGRSQLGDSFWMHYIFSDGSG-SDLVA------IWRVYLTYLNIVENGHDQESAIRWAKRF 676
            |:.:.|:.:|.:    |.....|:. ||.||      :||      ...:.|...|:  |:....
  Fly   898 FSLDIGQRRLAN----HQKALSGTKCSDHVAMIVASQMWR------REKQRGEHMEA--RFCDWK 950

  Fly   677 HVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMM-----------DDREKAIMLKVIIAGAF 730
            .:.:.::..|....|:|      |.|:.....|.:.|           ||....:.|.::..| .
  Fly   951 GLQMSTMNVIWDAKQQL------LDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLG-L 1008

  Fly   731 YPNYFTRSKESCADTDRNIYQTISGHDPCRTVYFTNFKPAYMGELYTRRIKELFQEVRIPPENMD 795
            |||                   |..|...|.|..|..|.|            |..:..:...|:.
  Fly  1009 YPN-------------------ICVHKEKRKVLTTESKAA------------LLHKTSVNCSNLA 1042

  Fly   796 VTF 798
            |||
  Fly  1043 VTF 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	211/636 (33%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
mle	NP_476641.1	DSRM	4..68	CDD:214634
		DSRM	170..240	CDD:214634
		DEXDc	393..569	CDD:214692	86/186 (46%)
		DEXDc	402..542	CDD:238005	71/146 (49%)
		ATP-synt_B	<584..644	CDD:304375	13/71 (18%)
		Helicase_C	643..772	CDD:278689	50/131 (38%)
		HA2	842..926	CDD:214852	27/96 (28%)
		OB_NTP_bind	974..1078	CDD:285018	21/104 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278674at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850