DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and CG4901

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	219/816 - (26%)
Similarity:	343/816 - (42%)	Gaps:	163/816 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DPRLMATKFKSSEVPNRELIGTDYVSKIVAKEK--CLLNGTLLNEQPQGKRIR-TLDDLDTDDEG 90
            |.:..||.       ..:.:|...| |...|.|  .:.|..:|.::|...:|: |:..:....:.
  Fly     2 DSKYFATS-------RNDAVGPSPV-KFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKR 58

  Fly    91 EETEIRRDDEYYKKFRFNLNRDKNLSIYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDE 155
            ...|               .:.|:|.::..|..||..:.|:..|:|..|||.|||||:||::|..
  Fly    59 TSIE---------------QQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLA 108

  Fly   156 AY-KSGKYCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVL 219
            .| |:|.   |.:|||||:|||::|.||.||..........:.|......| ..|::.:.|.|||
  Fly   109 GYAKNGM---IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTS-RATKIRFLTDGVL 169

  Fly   220 LNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSR------HVKIILMSATIDAKE 278
            |...|.::.|..|:.|:|||.|||..|.|.|..:|:.  |...|      ::|:::.|||:|...
  Fly   170 LRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKD--AQKERRKQKLANLKVVVTSATMDIDH 232

  Fly   279 LSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIWNEEDVGHQQVPEINKHGYRAAVKIIVI 343
            ..:||..........|...|..|:.|:            .||..|               .::|.
  Fly   233 FGNYFNCKGMYLEGRTYPVRVMHTKEE------------HEDYIH---------------TVLVT 270

  Fly   344 IDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENLTCMLENDPNIKVSIVRCFSL--- 405
            :.::.|    .:.:::|       |||||.|..||:::|:.:..:.:.| ....:.:|.|:|
  Fly   271 LFHIHR----TTPKNHD-------VLIFLTGQEEIESLAQQIRQLAKID-TTGTTDLRVFTLYAQ 323

  Fly   406 MTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWAS 470
            ::...|.:.|.|.|...||:||.|||||:|||:|.:..|||....|.|..:|......|:....|
  Fly   324 LSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRIS 388

  Fly   471 KANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFG---IPEMLRLPLQNSVLKAKVLNMGSPVE 532
            ||...|||||.||...|..||...|    .||..|.   .||:||....:.||           :
  Fly   389 KAQAWQRAGRAGRDADGTCYRAYTK----AEMDSFADATQPEILRTNPTSMVL-----------Q 438

  Fly   533 ILAL--------ALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTR 589
            :|||        .|.||....:.:....|..:||:....|....||       |..|.:.|||.:
  Fly   439 LLALDIDCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPL-------GRQMVQYPLDPK 496

  Fly   590 QSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYL 654
            .|:|::....|..:||.:.:.:.||:..:|.....::::  :...|..|....|.        :|
  Fly   497 YSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEM--AALAHAKFQSKHGD--------HL 551

  Fly   655 TYLNIVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQELRVRCTHLGLIPFPVNPNQMMDDREKA 719
            |.||:.......|....|....:::||||.....:.::||....||.|   .:|.:   ||.|
  Fly   552 TLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEHLHL---ALNSS---DDIE-- 608

  Fly   720 IMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISGHDPCR----TVYFTNFKPAYMGELYTRRI 780
             |||..|...|:.|.....::       ..|.|.||:...:    :|....:||:|:
  Fly   609 -MLKKCILNGFFENIAVLQRD-------GFYITASGNIRSKIHPSSVLHGKYKPSYI-------- 657

  Fly   781 KELFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIE 816
              ||.|:    ...:.||.....::.:     :||:
  Fly   658 --LFTEI----VQTEQTFLRQVTEISI-----EWIK 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	177/604 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
CG4901	NP_001334733.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840