DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and CG3225

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	222/773 - (28%)
Similarity:	332/773 - (42%)	Gaps:	175/773 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DDLDTDDEGEETEIRRDDEYYKKFRFNLNRD-------KNLSIYAKREEILAAINAHPVVIIKGE 139
            ||..||..|.|       :....|.||:|.:       :.|.|...|::||..:..|.|||:.||
  Fly    14 DDAITDSAGGE-------QQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGE 71

  Fly   140 TGCGKTTQVPQYILDEAYKSGKYCN--IVVTQPRRIAAISIANRVCQER-EWQQNTVCSFQVGLH 201
            ||.||:||||||:    |:.|.:..  |.:|:|||::.:::||||.||| |...:||......|.
  Fly    72 TGSGKSTQVPQYL----YEWGWHTKGLIGITEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLE 132

  Fly   202 RPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVK 266
            ..:|.  |::.:.|.|:||..::.:..||.|..|::||.|||:...|.:|.:::::|...| .:|
  Fly   133 SMSSC--TKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRS-SLK 194

  Fly   267 IILMSATIDAKELSDYFTTTNSIPPVITTN-HRRKHSIEKFYRD--------QLGSIIWNEEDVG 322
            :|:.||||||...|::|:...|....:..: ..|.|.:..||.:        :....:|..
  Fly   195 LIISSATIDASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKL---- 255

  Fly   323 HQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEI----DTMAE 383
            ||:.|.                                     |.:|.||.|..|:    |.:.|
  Fly   256 HQKEPP-------------------------------------GDILAFLTGQEEVLEALDLLRE 283

  Fly   384 NLTCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFC 448
            .:..  ....|:||  :..:..|:..:|..||..||.|.||::|.|||||:|||:|.:.||||..
  Fly   284 YIAS--SEQENLKV--LPMYGSMSSTDQLSVFFTPPKGTRKVVLATNIAETSITIPGIVYVIDCG 344

  Fly   449 LAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRL 513
            ..|||..:..:...||.:...|||:..|||||.||:|.|:|||:..|..|:...|. ..|||.|.
  Fly   345 YVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRLYTKSDYEALAPR-QPPEMRRS 408

  Fly   514 PLQNSVLKAKVLNMGSPVEILALAL-SPPNLSDIHNTILLLKEVGALYLTVDGIYDPLD--GDLT 575
            .|..::|:.|.|.:|:   ||.... |||   ...|.:..|:.:.||        |.:|  |:||
  Fly   409 ELSGAILQLKALGIGN---ILRFDFPSPP---PAQNLLSALESLFAL--------DAIDEQGNLT 459

  Fly   576 Y-WGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLSTPGLF-------AHEGGRSQLGDSF 632
            . .|.:::.||.....|:::.:.......||.|.|.|.|....:|       |.:.||.
  Fly   460 KPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGRI------ 518

  Fly   633 WMHYIFSDGSGSDLVAIWRVYLTYLN----IVENGHDQESAIRWAKRFHVSLRSLKEIHLLVQEL 693
             .|..|....|.        ::|.||    .||.|..:|    :..::.:..|:||..|.|.::|
  Fly   519 -AHRKFEVAEGD--------FITMLNAYTGFVEEGMTKE----FCGQYFLIYRNLKRAHSLREQL 570

  Fly   694 -RVRCTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAF-YPNYFTRSKESCADTDRNIYQTISG- 755
             .|.....|:..|     ....|.||  :.|.|.||.| ...|...|         .:|:.||.
  Fly   571 ITVARKKYGIPIF-----SCKGDVEK--LCKCITAGFFTQVAYLHHS---------GVYRQISSG 619

  Fly   756 -----HDPCRTVY-------------------FTNFKPAYMGELYTRRIKELFQEVRI 789
                 | |..|:|                   |.|:......|..|......:|:..:
  Fly   620 TELAIH-PNSTLYTLPQAQYVVYGELLQTTKLFMNYVTVIKREWLTELAPHYYQQTTV 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	188/615 (31%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	211/730 (29%)
		DEXDc	64..202	CDD:238005	56/144 (39%)
		HELICc	289..380	CDD:197757	40/92 (43%)
		HA2	448..534	CDD:214852	25/108 (23%)
		OB_NTP_bind	<581..670	CDD:285018	22/105 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840