DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-E and dhx16

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	939	Identity:	240/939 - (25%)
Similarity:	392/939 - (41%)	Gaps:	234/939 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DQEVMDFFDFSKELKRVAAAPQGYISSDPRLMATKFKSSEVPNRELIGTDYVSKI--VAKEKCLL 64
            :||.::  |...|:|     .:.|:          |.:..:.:||....:|...|  :|||....
Zfish   241 EQEKLE--DLEAEIK-----DEEYL----------FSTQNLTDRERKDLEYKRTIRDMAKEYKKA 288

  Fly    65 NGTLLNEQ------PQGKRIRTLDDLDTDDEGEET----------------------------EI 95
            ......|:      |:.||.:::...|.|.|.|||                            ..
Zfish   289 GAKEQEERKNRYYMPEEKRNKSIPQKDMDLEFEETPREGGGEQGRWEEARVATATLQFGARQERE 353

  Fly    96 RRDDEYYKKFRFNLNRD---------------------------------------KNLSIYAKR 121
            ||..|..::::..|..:                                       ::|.|:..|
Zfish   354 RRIKEEQERYQLILEEEEMITFVSTAITMKGTLSEKESEPELSQAEKQKQSIQEVRRSLPIFPYR 418

  Fly   122 EEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGKYCNIVVTQPRRIAAISIANRVCQER 186
            |::||||..|.:::|:||||.|||||:|||:|:|.|..|. ..|..|||||:||:|:|.||.||.
Zfish   419 EDLLAAIGDHQILVIEGETGSGKTTQIPQYLLEEGYTKGG-MKIGCTQPRRVAAMSVAARVAQEM 482

  Fly   187 EWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNKTLTHYTHIVLDEVHERDQNMDFLL 251
            ..:......:.:......| |.|.|.|.|.|:||...:....|..|:.|::||.|||..:.|.|.
Zfish   483 SVKLGNEVGYSIRFEDCTS-ERTILKYMTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILF 546

  Fly   252 IVVRRLLATNSRHVKIILMSATIDAKELSDYFTTTNSIPPVITTNHRRKHSIEKFYRDQLGSIIW 316
            .:::. :|.....:|:::.|||:|.:..|.:|...    ||.....||
Zfish   547 GLIKD-IARFRPDLKVLVASATLDTERFSSFFDDA----PVFRIPGRR----------------- 589

  Fly   317 NEEDVGHQQVPEINKHGYRAAVKIIVIIDNMERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTM 381
            ...|:.:.:.||.:   |..|..:.|:        .|...||      .|.||:||.|..||:..
Zfish   590 FPVDIYYTKAPEAD---YLEACVVSVL--------QIHVTQS------PGDVLVFLTGQEEIEAC 637

  Fly   382 AENL--TCMLENDPNIKVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYV 444
            .|.|  .|........::.::..::.:..:.|..:|||.|||.||:::.|||||:|:|:..:.||
Zfish   638 CELLQERCRRLGSKISELLVLPIYANLPSDMQAKIFNPTPPGARKVVVATNIAETSLTIDGIIYV 702

  Fly   445 ID--FCLAKVKVTDTASSFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGI 507
            ||  ||  |.|..:..:...||.:|..|:|:..|||||.||:.:|:.:|:.....::.||.|..:
Zfish   703 IDPGFC--KQKSYNAKTGMESLIVTPCSRASANQRAGRAGRVAAGKCFRLYTAWAFKHEMEETTV 765

  Fly   508 PEMLRLPLQNSVLKAKVLNMGSPVEILALALSPPNLSDIHNTILL-LKEVGALYLTVDGIYDPLD 571
            ||:.|..|.|.||..|.|.:...:..  ..:.||.    |.|::| |:::.||     |..:.|
Zfish   766 PEIQRTNLGNVVLLLKSLGINDLIHF--DFMDPPP----HETLVLALEQLYAL-----GALNHL- 818

  Fly   572 GDLTYWGTIMSRLPLDTRQSRLIILGYIFNMLEEAIIIAAGLS-TPGLFAHEGGRSQLGDSFWMH 635
            |:||..|..|:.||:|...|::|:....:...||.:.|||.|| ...:|.....:....|:..|:
Zfish   819 GELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNSIFYRPKDKVVHADNARMN 883

  Fly   636 YIFSDGSGSDLVAIWRVYLTYLNIVENGHDQESAIRWAKRFHVSLRSLK-------EIHLLVQEL 693
            ::.   .|.|.:.:..||..:   ||:|:    :.:|.....:..||:|       ::..|:..:
Zfish   884 FVV---PGGDHLVLLNVYTQW---VESGY----STQWCFENFIQFRSMKRARDVRDQLEGLMDRI 938

  Fly   694 RVR-CTHLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFYPNYFTRSKESCADTDRNIYQTISGHD 757
            .|. |:..|               :...:.|.:.||.||         ..|...:..|:|:. |.
Zfish   939 EVELCSSNG---------------DSMPIRKAVTAGYFY---------HTARLSKGGYKTVK-HQ 978

  Fly   758 PCRTVY------FTNFKPAYMGELYTRRI---KELFQEV---------RIPPENMDVTFQEGSQK 804
              :|||      ....:|.:|  :|...:   ||..::|         .:.|.
Zfish   979 --QTVYVHPNSSLFEEQPRWM--IYHELVFTTKEFMRQVIEIESGWLLEVAPH------------ 1027

  Fly   805 VFVTFKQDDWIEGSSKYVP-VSGRVQSEV 832
               .:|..:..:.|||.:| ..|:.:.|:
Zfish  1028 ---YYKNKELEDSSSKKMPRKQGKAREEL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	184/597 (31%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923
		GBP_C	<177..296	CDD:303769	14/71 (20%)
		coiled coil	271..285	CDD:293879	4/13 (31%)
		DEXDc	407..594	CDD:214692	71/210 (34%)
		DEXDc	429..568	CDD:238005	54/141 (38%)
		Helicase_C	612..742	CDD:278689	50/145 (34%)
		HA2	811..895	CDD:214852	26/92 (28%)
		OB_NTP_bind	916..1028	CDD:285018	26/155 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810