DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-E and l(1)G0007

DIOPT Version :9

Sequence 1:	NP_476741.1	Gene:	spn-E / 41919	FlyBaseID:	FBgn0003483	Length:	1434	Species:	Drosophila melanogaster
Sequence 2:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	216/780 - (27%)
Similarity:	355/780 - (45%)	Gaps:	151/780 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DFSKE-LKRVAAAPQGYISS--DPRLMATKFKSSEVPNRELIGTDYVSKIVAKEKCL-------- 63
            ||.:| |:||.......|..  |.|::.||.....||.::  .|..::.:..|...|
  Fly   395 DFDEEALERVHLLVHHIIPPFLDGRIVFTKQPEPVVPVKD--PTSDMALLARKGSALVRNYREQK 457

  Fly    64 -----------LNGTLLN-----EQPQGKRIRTLDDLDTDDEGEETEIRRDDEYYKKFR------ 106
                       |:||.|.     ::||.:     ||:..|.|.::.:.|:|.::....|
  Fly   458 ERRKAQKKHWELSGTKLGNIMGVQRPQDE-----DDMRFDKEKDKADYRKDQKFADHMRDQDTGG 517

  Fly   107 -FNLNRDKNLS-------IYAKREEILAAINAHPVVIIKGETGCGKTTQVPQYILDEAY-KSGKY 162
             .:.:|.|.:|       ::|.|:|:|..|..:.|:||.||||.|||||:.||:.::.| |.|.
  Fly   518 KSDFSRKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRGM- 581

  Fly   163 CNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVGLHRPNSLEDTRLLYCTTGVLLNNLINNK 227
              |..|||||:||:|:|.||..|.:.|......:.:......| |.|.:.|.|.|:||...:.:.
  Fly   582 --IGCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTS-ERTVIKYMTDGILLRESLRDP 643

  Fly   228 TLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRH-VKIILMSATIDAKELSDYF--TTTNSI 289
            .|..|:.|::||.|||..:.|.|..::|.::|  .|| :|:|:.|||:|:.:.:.:|  ..|.:|
  Fly   644 ELDSYSAIIMDEAHERSLSTDVLFGLLREIVA--RRHDLKLIVTSATMDSSKFATFFGNVPTFTI 706

  Fly   290 P----PVITTNHRRKHSIEKFYRDQLGSIIWNE---EDVGHQQVPEINKHGYRAAVKIIVIIDNM 347
            |    ||                    .:::::   ||.....|
  Fly   707 PGRTFPV--------------------DVMFSKNTCEDYVESAV--------------------- 730

  Fly   348 ERKAAIQSRQSYDEALRYGAVLIFLPGIYEIDTMAENL---TCMLENDPNIKVSIVRCFSLMTPE 409
              |.|:|...:.:|    |.:|||:||..:|:...|.|   ...::|.|  .:||:..:|.:..:
  Fly   731 --KQALQVHLTPNE----GDMLIFMPGQEDIEVTCEVLEERLAEIDNAP--ALSILPIYSQLPSD 787

  Fly   410 NQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTASSFSSLRLTWASKANC 474
            .|..:|.....|.||.::.|||||:|:||..:.||||....|:||.:......:|::...|:||.
  Fly   788 LQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQIYPISQANA 852

  Fly   475 RQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKVLNMGSPVEILAL-AL 538
            .||:||.||...|:.||:..:..|:.|:....:||:.|..|.|:||..|.|.:   |::|.. .:
  Fly   853 NQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGV---VDLLQFHFM 914

  Fly   539 SPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTRQSRLIILGYIFNML 603
            .||...:|.|::..|..:|||..|         |.||..|..|:..|||..|.:::|:.......
  Fly   915 DPPPQDNILNSLYQLWILGALDHT---------GALTTLGRQMAEFPLDPPQCQMLIVACRMGCS 970

  Fly   604 EEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYLTYLNIVENGHDQES 668
            .|.:||.:.||.|.:|....||....|.....:   ....||       :|||||:.:.......
  Fly   971 AEVLIIVSMLSVPSIFYRPKGREDEADGVREKF---QRPESD-------HLTYLNVYQQWRQNNY 1025

  Fly   669 AIRWAKRFHVSLRSLKEIHLLVQELRVRCT--HLGLIPFPVNPNQMMDDREKAIMLKVIIAGAFY 731
            :..|.....:.:::::::..:.|:|:...|  :|.:|...::.:         |:.|.|.:..||
  Fly  1026 SSTWCNEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGIDWD---------IVRKCICSAYFY 1081

Fly 732 731
Fly 1082 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-E	NP_476741.1	HrpA	113..>697	CDD:224557	178/605 (29%)
spn-E	NP_476741.1	TUDOR	892..1016	CDD:395449
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	70/211 (33%)
		DEXDc	551..689	CDD:238005	57/143 (40%)
		HELICc	722..870	CDD:238034	53/176 (30%)
		HA2	932..1014	CDD:214852	28/100 (28%)
		OB_NTP_bind	1048..1148	CDD:285018	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468046
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840